ID A0A2K6KT78_RHIBE Unreviewed; 984 AA.
AC A0A2K6KT78;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Corin, serine peptidase {ECO:0000313|Ensembl:ENSRBIP00000014474.1};
GN Name=CORIN {ECO:0000313|Ensembl:ENSRBIP00000014474.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000014474.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000014474.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000014474.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; A0A2K6KT78; -.
DR Ensembl; ENSRBIT00000038308.1; ENSRBIP00000014474.1; ENSRBIG00000031285.1.
DR GeneTree; ENSGT00940000157103; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0016486; P:peptide hormone processing; IEA:InterPro.
DR GO; GO:0008217; P:regulation of blood pressure; IEA:InterPro.
DR CDD; cd07445; CRD_corin_1; 1.
DR CDD; cd07888; CRD_corin_2; 1.
DR CDD; cd00112; LDLa; 6.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 6.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR017052; Corin.
DR InterPro; IPR041762; Corin_CRD_1.
DR InterPro; IPR041763; Corin_CRD_2.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF9; ATRIAL NATRIURETIC PEPTIDE-CONVERTING ENZYME ISOFORM X1; 1.
DR Pfam; PF01392; Fz; 2.
DR Pfam; PF00057; Ldl_recept_a; 5.
DR Pfam; PF15494; SRCR_2; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PIRSF; PIRSF036376; Corin; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00063; FRI; 2.
DR SMART; SM00192; LDLa; 6.
DR SMART; SM00202; SR; 1.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 6.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50038; FZ; 2.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 6.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 113..238
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 392..515
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 744..977
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT ACT_SITE 785
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036376-50"
FT ACT_SITE 834
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036376-50"
FT ACT_SITE 927
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036376-50"
FT DISULFID 195..219
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 256..274
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 268..283
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 285..297
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 292..310
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 304..319
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 329..347
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 341..356
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 444..482
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 471..512
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 475..499
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 522..534
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 529..547
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 541..556
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 579..594
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 597..609
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 604..622
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 616..631
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 984 AA; 110135 MW; D9BA89304E166194 CRC64;
VLRADDNNMG NGCSQKLVTA NLLRFLLLVL IPCICALILL LVILLSYVGT LQKVYFKSNG
SEPLVTDGEI QGSDVILTNT IYNQSTVIST AHPDQHIPAW TTDASLPGDQ SHRNTSACMN
ITHSQCQMLP YHSTLTPLLS VVRNMEMEKF LKFFTYLHRL SCYQHIMLFG CSLAFPECII
DGDDSHGLLP CRSFCEAAKE GCESVLGMVN YSWPDFLKCS QFRNHTESSN VSRICFSPQQ
ENGKQLLCGG GESFLCASGI CIPRKLQCNG YNDCDDWSDE AHCNCSENLF HCHTGKCLNY
SLVCDGYDDC GDLSDEQNCA CHSQGLVECR NGQCIPSTFQ CDGDEDCKDG SDEENCSGSQ
TLCQEGDRRC LYIPCIDLCG GSSLCDPNNS LNNCSQCEPI TLELCMNLPY NSTSYPNYLG
HRTQKEASIS WESSLFPALV QTNCYKYLMF FACTILVPKC DVNTGQSIPP CRALCEHSKE
RCESVLGIVG LQWPEHTDCS QFPEENSDNQ TCLMPDEYVE ECSPSHFKCR SGRCVLASRR
CDGQADCDDD SDEENCGCKE RDLWECPSNK QCLKHTVICD GFPDCPDYMD EKNCSFCQDD
ELECANHACV SRNLWCDGEA DCSDSSDEWD CVTLSINVNS SSFLMVHRAA TEHHVCADGW
REMFSQLACK QMGLGEPSVT KLIQEQEKEL RWLTLHSNWE SLNGTTLHEL LVNGQSCQSR
SKISLLCTKQ DCGRRPAARM NKRILGGRTS RPGRWPWQCS LQSEPSGHIC GCVLIAKKWV
LTVAHCFEGR ENAAVWKVVL GINNLDHPSV FMQTRFVKTI ILHPRYSRAV VDYDISIIEL
NEDISETGYV RPVCLPSPEQ WLEPDTYCYI TGWGHMGNKM PFKLQEGEVR IIPLEQCQSY
FDMKTITTRM ICAGYESGTV DSCMGDSGGP LVCEKPGGQW TLFGLTSWGS VCFSKVLGPG
VYSNVSYFVE WIKRQIYIQT FLLN
//
