ID A0A2K6KU90_RHIBE Unreviewed; 346 AA.
AC A0A2K6KU90;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA repair protein {ECO:0000256|PIRNR:PIRNR005856};
GN Name=XRCC3 {ECO:0000313|Ensembl:ENSRBIP00000014837.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000014837.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000014837.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000014837.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the homologous recombination repair (HRR) pathway
CC of double-stranded DNA, thought to repair chromosomal fragmentation,
CC translocations and deletions. {ECO:0000256|PIRNR:PIRNR005856}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR005856}.
CC Cytoplasm {ECO:0000256|PIRNR:PIRNR005856}.
CC -!- SIMILARITY: Belongs to the RecA family. RAD51 subfamily.
CC {ECO:0000256|PIRNR:PIRNR005856}.
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DR RefSeq; XP_017717377.1; XM_017861888.1.
DR RefSeq; XP_017717378.1; XM_017861889.1.
DR AlphaFoldDB; A0A2K6KU90; -.
DR Ensembl; ENSRBIT00000038676.1; ENSRBIP00000014837.1; ENSRBIG00000031535.1.
DR GeneID; 108521878; -.
DR KEGG; rbb:108521878; -.
DR CTD; 7517; -.
DR GeneTree; ENSGT00930000151053; -.
DR OMA; PCLGLQW; -.
DR OrthoDB; 3177495at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd19491; XRCC3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR InterPro; IPR016467; DNA_recomb/repair_RecA-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR047348; XRCC3-like_C.
DR PANTHER; PTHR46487; DNA REPAIR PROTEIN XRCC3; 1.
DR PANTHER; PTHR46487:SF1; DNA REPAIR PROTEIN XRCC3; 1.
DR Pfam; PF08423; Rad51; 1.
DR PIRSF; PIRSF005856; Rad51; 1.
DR SUPFAM; SSF47789; C-terminal domain of RNA polymerase alpha subunit; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50162; RECA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR005856};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|PIRNR:PIRNR005856};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 78..259
FT /note="RecA family profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50162"
SQ SEQUENCE 346 AA; 37941 MW; 71EE7FE6F4EEA8AC CRC64;
MDLDLLDLNP RIIAAIKKAK LKSVKEVLHF SGSDLKRLTN LSSPEVWQLL RTASLHLRGS
SILTALHLHQ QKERFPAQHQ RLSLGCPVLD SLLRGGLPLD GITELAGRSS VGKTQLALQL
CLAVQFPRQH GGLEAGAVYI CTEDAFPHKR LQQLMAQQPR LRTDVPGELL QKLRFGSQIF
IEHVADVDAL LECVNKKVPV LLSRGMARLV VIDSVAAPFR CEFDSQASAP RARRLQSLGA
ALRELSSAFQ SPVLCINQVT EAMEEPGAAH GPLRFWDERV SPALGITWAN QLLVRLLAER
LREEEAAVGC PARTLRVLFA PHLPPSSCSY TISAEGVRGT PGTQSH
//
