ID   A0A2K6KUM1_RHIBE        Unreviewed;       339 AA.
AC   A0A2K6KUM1;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Adenosine deaminase {ECO:0000256|ARBA:ARBA00018099};
DE            EC=3.5.4.4 {ECO:0000256|ARBA:ARBA00012784};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000014973.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000014973.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000014973.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC       Cell membrane {ECO:0000256|ARBA:ARBA00004296}; Peripheral membrane
CC       protein {ECO:0000256|ARBA:ARBA00004296}; Extracellular side
CC       {ECO:0000256|ARBA:ARBA00004296}. Cytoplasmic vesicle lumen
CC       {ECO:0000256|ARBA:ARBA00004321}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR   RefSeq; XP_017733494.1; XM_017878005.1.
DR   AlphaFoldDB; A0A2K6KUM1; -.
DR   Ensembl; ENSRBIT00000038813.1; ENSRBIP00000014973.1; ENSRBIG00000031584.1.
DR   GeneID; 108533377; -.
DR   CTD; 100; -.
DR   GeneTree; ENSGT00950000183113; -.
DR   OrthoDB; 36100at2759; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0060205; C:cytoplasmic vesicle lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046936; F:2'-deoxyadenosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   CDD; cd01320; ADA; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 2.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR   PANTHER; PTHR11409:SF43; ADENOSINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT   DOMAIN          10..202
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   339 AA;  38332 MW;  C6FBAEFDA0CDA608 CRC64;
     MTQTPAFDKP KVELHVHLDG AIKPETILYY GRRRGIALPA NTAEGLLNVI GMDKPLTLPD
     FLAKFDYYMP AIAGCREAIK RIAYEFIEMK AKEGVVYVEV RYSPHLLANS KVEPIPWNQA
     EGDLTPDEVV ALVGQGLQEG ERDFGVKARS ILCCMRHQPN WSPEVVELCK KYQQQTVVAI
     DLAGDETIPG SSLLPGHVQA YQAVDILKTE RLGHGYHTLE DQALYDRLRQ ENMHFEICPW
     SSYLTGAWKP DTEHAVVRLK NDQANYSLNT DDPLIFKSTL DTDYQMTKRD MGFTEEEFKR
     LNINAAKSSF LPEDEKRELL DLLYKAYGMP PSASAGQHL
//