ID A0A2K6KV48_RHIBE Unreviewed; 1198 AA.
AC A0A2K6KV48;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A7 {ECO:0000313|Ensembl:ENSRBIP00000015142.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000015142.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000015142.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000015142.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR AlphaFoldDB; A0A2K6KV48; -.
DR Ensembl; ENSRBIT00000038982.1; ENSRBIP00000015142.1; ENSRBIG00000031613.1.
DR GeneTree; ENSGT00940000157045; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022853; F:active monoatomic ion transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR GO; GO:0098660; P:inorganic ion transmembrane transport; IEA:UniProt.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF105; SODIUM BICARBONATE COTRANSPORTER 3; 1.
DR Pfam; PF07565; Band_3_cyto; 2.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 585..607
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 672..695
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 702..720
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 800..818
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 838..855
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 886..905
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 926..950
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 986..1005
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1012..1035
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1071..1102
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 129..226
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 362..507
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 556..1072
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 42..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1128..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..60
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1198 AA; 134442 MW; CA3D1DAB83770130 CRC64;
MRMISVVDLG KTSSTVNTKF EKEELESHRA VYIGVHVPFS KESRRRHRHR GHKHHHRRRK
DKESDKEDGR ESPSYDTPSQ RVQFILGTED DDEEHIPHDL FTEMDELCYR DGEEYEWKET
ARWLKFEEDV EDGGDRWSKP YVATLSLHSL FELRSCILNG TVMLDMRAST LDEIADMVLD
NMIASGQLDE SIRENVREAL LKRHHHQNEK RFTSRIPLLV RITMRTREGL SASRHSLRTG
LSASNLSLRG ESPLSLLLGH LLPSSRAGTP AGSRCTTPVP TPQNSPPSSP SISRLTSRSS
QQSQLQAPEL LVSPASDDIP TVVIHPPEED LEAALKGEEQ KNEENVDLTP GILASPQSAP
GNLDNSKSGE IKGNGSGGSR ENSTVDFSKV DMNFMRKIPT GAEASNVLVG EVDFLERPII
AFVRLAPAVL LTGLTEVPVP TRFLFLLLGP AGKAPQYHEI GRSIATLMTD EIFHDVAYKA
KDRNDLLSGI DEFLDQVTVL PPGEWDPSIR IEPPKSVPSQ EKRKIPVFHN GSTPISGETP
KEAAHHAGPE LQRTGRLFGG LILDIKRKAP FFLSDFKDAL SLQCLASILF LYCACMSPVI
TFGGLLGEAT EGRISAIESL FGASLTGIAY SLFAGQPLTI LGSTGPVLVF EKILYKFCRD
YQLSYLSLRT SIGLWTSFLC IVLVATDASS LVCYITRFTE EAFAALICII FIYEALEKLF
DLGETYAFNM HNNLDKLTSY SCVCTEPPNP SNETLAQWKK ENITAHNISW KNLTVSECKK
LHGVFLGSAC GHHGPYIPDV LFWCVILFFT TFFLSSFLKQ FKTKRYFPTK VRSTISDFAV
FLTIVIMVTI DYLVGVPSPK LHVPEKFEPT HPERGWIINP LGDNPWWTLL IAAIPALLCT
ILIFMDQQIT AVIINRKEHK LKKGAGYHLD LLMVGVMLGV CSVMGLPWFV AATVLSISHV
NSLKVESECS APGEQPKFLG IREQRVTGLM IFILMGLSVF MTSVLKFIPM PVLYGVFLYM
GVSSLKGIQY LMIFYRNLFD RIKLFGMPAK HQPDLIYLRY VPLWKVHIFT VIQLTCLVLL
WVIKVSAAAV VFPMMVLALV FVRKLMDLCF TKRELSWLDD LMPESKKKKE DDKKKKEKEE
AERMLQDDDD TVHLPFEGGS LLQIPVKALK YSPDKPVSVK ISFEDEPRKK YVDAETSL
//
