ID A0A2K6KVB4_RHIBE Unreviewed; 975 AA.
AC A0A2K6KVB4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Spectrin repeat containing nuclear envelope family member 3 {ECO:0000313|Ensembl:ENSRBIP00000015204.1};
GN Name=SYNE3 {ECO:0000313|Ensembl:ENSRBIP00000015204.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000015204.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000015204.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000015204.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
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DR RefSeq; XP_017713441.1; XM_017857952.1.
DR RefSeq; XP_017713442.1; XM_017857953.1.
DR RefSeq; XP_017713443.1; XM_017857954.1.
DR RefSeq; XP_017713444.1; XM_017857955.1.
DR RefSeq; XP_017713445.1; XM_017857956.1.
DR STRING; 61621.ENSRBIP00000015204; -.
DR Ensembl; ENSRBIT00000039045.1; ENSRBIP00000015204.1; ENSRBIG00000031694.1.
DR Ensembl; ENSRBIT00000039046.1; ENSRBIP00000015205.1; ENSRBIG00000031694.1.
DR GeneID; 108519142; -.
DR KEGG; rbb:108519142; -.
DR CTD; 161176; -.
DR GeneTree; ENSGT00440000039367; -.
DR OrthoDB; 4106312at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0034993; C:meiotic nuclear membrane microtubule tethering complex; IEA:Ensembl.
DR GO; GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0140444; F:cytoskeleton-nuclear membrane anchor activity; IEA:Ensembl.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0090150; P:establishment of protein localization to membrane; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR Gene3D; 1.20.58.60; -; 3.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR47535; MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G; 1.
DR PANTHER; PTHR47535:SF2; NESPRIN-3; 1.
DR Pfam; PF10541; KASH; 1.
DR SMART; SM01249; KASH; 1.
DR SMART; SM00150; SPEC; 3.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS51049; KASH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TOPO_DOM 1..925
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TRANSMEM 926..944
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 947..975
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 917..975
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
FT COILED 295..357
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 975 AA; 112310 MW; 5B58692F75F93DDE CRC64;
MTQQPQEDFD RSVEDAQAWM KAVQDQLQVN DNTQGPLAAL EARLWETEKI CQLEPEGRVK
VDLVLRMAEA LLACCPGDQK PEILAQLKDI KAQWEETVTY MTHCHSRIEW VWLHWSEYLL
AQDEFYRWFQ KMMVTLEPHI ELQLGLKEKQ WQLSHAQVLL HNVDNQAVLL DRLLEEAASL
FNRIGDPSVD EDAQKRMKAK YDAVKAKAQD RVDLLEQVAR EHEEYQAGVD EFQLWLKAVV
EKVNGCLGRK CRLPITQRLS TLQDIAKDFP RGEQSLERLE EQSVGVIRNT SPLGAEKITG
ELEEMRKVLE KLRALWEEEE ERLRGLLQSR GAFEQQIKQL EAELSEFRMV LQRLAQEGLQ
PAAKAGTEDE LVAHWRRYSA TRAALASEEP RVDRLQAQLK ELIVFPHDLK PLSDSVVTAI
QEYRSLKGKS ARLCNAAGVE LWQHFQQPLQ DLQLWRALAQ RLLEVTASLQ DLPSLHTFLP
QIEAALMESS RLKEPLTMLQ LKKDLLIGVF GQERATALLE QVVGSVRDRD LLHNSLLQRK
SKLQSLLAQH KDFGAAFEPL QRKLLDLQVR VQAEKELQRD LPGKQAQLSR LQGLQEEGLD
LGAQMEAARP LVQENPNHQH KMDQLSSDFQ ALQRSLEDLV DRCRQSVEEH CTFSHQLLEL
RQWITVTTQK LEAHRGEAGP GDAESQEAEF ERLVAEFPEK EAQLSLVEAQ GWLVMEKSSA
EGAAMVQEEL RELAESWRAL RLLEESLLSL IRNWHLQRME VDSGKKMVFT NNIPKSGFLI
DPMDPIPRHR RQVNLLQEEE GSHEDFSQLL RNFEQWLQVE NSKLVRIIAM RTSTAEDLRT
RESKLQELEA RVPEGQHLFE NLLHLGPARG TSDKLEDLRY QWMLYKSKLK DSGYLLTQSS
PGEPTGFQKT RRWRGLGSLF RRVCCVALPL QLLLLLFLLL LFLLPIREED RSCTLANNFA
RSFTLMLRYN GPPPT
//
