ID   A0A2K6KWW1_RHIBE        Unreviewed;       814 AA.
AC   A0A2K6KWW1;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=IQ motif and Sec7 domain ArfGEF 1 {ECO:0000313|Ensembl:ENSRBIP00000015761.1};
GN   Name=IQSEC1 {ECO:0000313|Ensembl:ENSRBIP00000015761.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000015761.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000015761.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000015761.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the BRAG family.
CC       {ECO:0000256|ARBA:ARBA00006248}.
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DR   AlphaFoldDB; A0A2K6KWW1; -.
DR   Ensembl; ENSRBIT00000039605.1; ENSRBIP00000015761.1; ENSRBIG00000031968.1.
DR   GeneTree; ENSGT00940000156915; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd13318; PH_IQSEC; 1.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR033742; IQSEC_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR10663:SF327; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF16453; IQ_SEC7_PH; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT   DOMAIN          395..588
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   REGION          190..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..282
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..321
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..376
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   814 AA;  92047 MW;  765E06B17DFCD01E CRC64;
     MLERKYGGRL VTRHAARTIQ TAFRQYQMNK NFERLRSSMS ENRMSRRIVL SNMRMQFSFE
     GPEKVHSSYF EGKQVSVTND GSQLGALVPP ECGDLSEPTT LKSPAPSSDF ADAITELEDA
     FSRQVKSLAE SIDDALNCRS LHTEEAPALD AARARDTEPQ TALHSMDHRK LDEMTASYSD
     VTLYIDEEEL SPPLPLSQAG DRPSSTESDL RLRAGGAAPD YWALAHKEDK ADTDTSCRST
     PSLERQEQRL RVEHLPLLTI EPPSDSSVDL SDRSERGSLK RQSAYERSLG GQQGSPKHGP
     HSGPPKSLPR EEPELRPRPP RPLDSHLAIN GSANRQSKSE SDYSDGDNDS INSTSNSNDT
     INCSSESSSR DSLREQTLSK QTYHKEARNS WDSPAFSNDV IRKRHYRIGL NLFNKKPEKG
     VQYLIERGFV PDTPVGVAHF LLQRKGLSRQ MIGEFLGNRQ KQFNRDVLDC VVDEMDFSTM
     ELDEALRKFQ AHIRVQGEAQ KVERLIEAFS QRYCICNPGV VRQFRNPDTI FILAFAIILL
     NTDMYSPNVK PERKMKLEDF IKNLRGVDDG EDIPREMLIG IYERIRKREL KTNEDHVSQV
     QKVEKLIVGK KPIGSLHPGL GCVLSLPHRR LVCYCRLFEV PDPNKPQKLG LHQREIFLFN
     DLLVVTKIFQ KKKNSVTYSF RQSFSLYGMQ VLLFENQYYP NGIRLTSSVP GADIKVLINF
     NAPNPQDRKK FTDDLRESIA EVQEMEKHRI ESELEKQKGV VRPSMSQCSS LKKESGNGTL
     SRACLDDSYA SGEGLKRSAL SSSLRDLSEA GVHH
//