ID A0A2K6KZG6_RHIBE Unreviewed; 1086 AA.
AC A0A2K6KZG6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Solute carrier family 12 member 1 {ECO:0000313|Ensembl:ENSRBIP00000016668.1};
GN Name=SLC12A1 {ECO:0000313|Ensembl:ENSRBIP00000016668.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000016668.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000016668.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000016668.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A2K6KZG6; -.
DR Ensembl; ENSRBIT00000040516.1; ENSRBIP00000016668.1; ENSRBIG00000032330.1.
DR GeneTree; ENSGT00940000158030; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IEA:UniProt.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002445; Slc12a1.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF93; SOLUTE CARRIER FAMILY 12 MEMBER 1; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
DR PRINTS; PR01209; NAKCLTRSPRT2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 184..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 596..620
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 902..919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 90..151
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 177..678
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 687..1086
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 31..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 817..844
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1086 AA; 120782 MW; 1081B51AD1CB87D2 CRC64;
MSLNNSSNIF LDSVPSNTNR FQVNVINENH ESSAVANDNT DPPHYEETSF GDEAQKRLRI
SFRPGNQECY DNFLQSGETA KTDASFHAYD SHTNTYYLQT FGHNTMDAVP KIEYYRNTGS
ISGPKVNRPS LLEIHEQLTK VSLKDTVNKA GAQHYEELRV LSHYHCPVSF QYRFYPQVRC
MLNIWGVMLF IRLSWIVGEA GIGLGVLIIL LSTMVTSITG LSTSAIATNG FVRGGGAYYL
ISRSLGPEFG GSIGLIFAFA NAVAVAMYVV GFAETVVDLL KESDSMMVDP SNDIRIIGSI
TVVILLGISV AGMEWEAKAQ VILLVILLIA IVNFFIGTVI PSNNEKKSRG FFNYQASIFA
ENFGPRFTKG EGFFSVFAIF FPAATGILAG ANISGDLEDP QDAIPRGTML AIFITTIAYL
GVAICVGACV VRDATGNMND TIISGMNCNG SAACGLGYDF SRCRHEPCQY GLMNNFQVMS
MVSGFGPLIT AGIFSATLSS ALASLVSAPK VFQALCKDNI YKALQFFAKG YGKNNEPLRG
YILTFLIAMA FILIAELNTI APIISNFFLA SYALINFSCF HASYAKSPGW RPAYGIYNMW
VSLFGAVLCC AVMFVINWWA AVITYVIEFF LYVYVTYKKP DVNWGSSTQA LSYVSALDNA
LELTTVEDHV KNFRPQCIVL TGGPMTRPAL LDITHAFTKN SGLCICCEVF VGPRKLCVKE
MNSGMAKKQA WLIKNKIKAF YAAVAADCFR DGVRSLLQAS GLGRMKPNTL VIGYKKNWRK
APLTEIENYV GIIHDAFDFE IGVVIVRISQ GFDISQVLQV QEELERLEQE RLALEATIKD
NECEEESGGI RGLFKKAGKL NITKTTPKKD GSINTIQSMH VGEFNQKLVE ASTQFKRNKK
KAQLMFGGLT LLIPYILTLR KKWKDCKLRI YVGGKINRIE EEKITMASLL SKFRIKFADI
HIIGDINIKP NKESWKVFEE MIEPYRLHES CKDLTTAEKL KRETPWKITD AELEAVKEKS
YRQVRLNELL QERSRAANLI VLSLPVARKG SISDLLYMAW LEILTKNLPP VLLVRGNHKN
VLTFYS
//