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Database: UniProt
Entry: A0A2K6KZG6_RHIBE
LinkDB: A0A2K6KZG6_RHIBE
Original site: A0A2K6KZG6_RHIBE 
ID   A0A2K6KZG6_RHIBE        Unreviewed;      1086 AA.
AC   A0A2K6KZG6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Solute carrier family 12 member 1 {ECO:0000313|Ensembl:ENSRBIP00000016668.1};
GN   Name=SLC12A1 {ECO:0000313|Ensembl:ENSRBIP00000016668.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000016668.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000016668.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000016668.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC         K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC         ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC         Evidence={ECO:0000256|ARBA:ARBA00034631};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC         Evidence={ECO:0000256|ARBA:ARBA00034631};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
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DR   AlphaFoldDB; A0A2K6KZG6; -.
DR   Ensembl; ENSRBIT00000040516.1; ENSRBIP00000016668.1; ENSRBIG00000032330.1.
DR   GeneTree; ENSGT00940000158030; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProt.
DR   GO; GO:0035725; P:sodium ion transmembrane transport; IEA:UniProt.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR013612; AA_permease_N.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR002445; Slc12a1.
DR   InterPro; IPR002443; SLC12A1/SLC12A2.
DR   InterPro; IPR004842; SLC12A_fam.
DR   NCBIfam; TIGR00930; 2a30; 1.
DR   PANTHER; PTHR11827:SF93; SOLUTE CARRIER FAMILY 12 MEMBER 1; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF08403; AA_permease_N; 1.
DR   Pfam; PF03522; SLC12; 1.
DR   PRINTS; PR01207; NAKCLTRNSPRT.
DR   PRINTS; PR01209; NAKCLTRSPRT2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        184..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        294..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        319..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        372..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        411..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        538..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        563..584
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        596..620
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        902..919
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          90..151
FT                   /note="Amino acid permease N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08403"
FT   DOMAIN          177..678
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          687..1086
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   REGION          31..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          817..844
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1086 AA;  120782 MW;  1081B51AD1CB87D2 CRC64;
     MSLNNSSNIF LDSVPSNTNR FQVNVINENH ESSAVANDNT DPPHYEETSF GDEAQKRLRI
     SFRPGNQECY DNFLQSGETA KTDASFHAYD SHTNTYYLQT FGHNTMDAVP KIEYYRNTGS
     ISGPKVNRPS LLEIHEQLTK VSLKDTVNKA GAQHYEELRV LSHYHCPVSF QYRFYPQVRC
     MLNIWGVMLF IRLSWIVGEA GIGLGVLIIL LSTMVTSITG LSTSAIATNG FVRGGGAYYL
     ISRSLGPEFG GSIGLIFAFA NAVAVAMYVV GFAETVVDLL KESDSMMVDP SNDIRIIGSI
     TVVILLGISV AGMEWEAKAQ VILLVILLIA IVNFFIGTVI PSNNEKKSRG FFNYQASIFA
     ENFGPRFTKG EGFFSVFAIF FPAATGILAG ANISGDLEDP QDAIPRGTML AIFITTIAYL
     GVAICVGACV VRDATGNMND TIISGMNCNG SAACGLGYDF SRCRHEPCQY GLMNNFQVMS
     MVSGFGPLIT AGIFSATLSS ALASLVSAPK VFQALCKDNI YKALQFFAKG YGKNNEPLRG
     YILTFLIAMA FILIAELNTI APIISNFFLA SYALINFSCF HASYAKSPGW RPAYGIYNMW
     VSLFGAVLCC AVMFVINWWA AVITYVIEFF LYVYVTYKKP DVNWGSSTQA LSYVSALDNA
     LELTTVEDHV KNFRPQCIVL TGGPMTRPAL LDITHAFTKN SGLCICCEVF VGPRKLCVKE
     MNSGMAKKQA WLIKNKIKAF YAAVAADCFR DGVRSLLQAS GLGRMKPNTL VIGYKKNWRK
     APLTEIENYV GIIHDAFDFE IGVVIVRISQ GFDISQVLQV QEELERLEQE RLALEATIKD
     NECEEESGGI RGLFKKAGKL NITKTTPKKD GSINTIQSMH VGEFNQKLVE ASTQFKRNKK
     KAQLMFGGLT LLIPYILTLR KKWKDCKLRI YVGGKINRIE EEKITMASLL SKFRIKFADI
     HIIGDINIKP NKESWKVFEE MIEPYRLHES CKDLTTAEKL KRETPWKITD AELEAVKEKS
     YRQVRLNELL QERSRAANLI VLSLPVARKG SISDLLYMAW LEILTKNLPP VLLVRGNHKN
     VLTFYS
//
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