ID   A0A2K6KZJ2_RHIBE        Unreviewed;       505 AA.
AC   A0A2K6KZJ2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Prolyl 3-hydroxylase OGFOD1 {ECO:0000256|ARBA:ARBA00016364};
DE   AltName: Full=2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 {ECO:0000256|ARBA:ARBA00031489};
DE   AltName: Full=uS12 prolyl 3-hydroxylase {ECO:0000256|ARBA:ARBA00029938};
GN   Name=OGFOD1 {ECO:0000313|Ensembl:ENSRBIP00000016672.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000016672.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000016672.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000016672.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 =
CC         [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate;
CC         Xref=Rhea:RHEA:54156, Rhea:RHEA-COMP:13816, Rhea:RHEA-COMP:13818,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:30031, ChEBI:CHEBI:50342, ChEBI:CHEBI:85428;
CC         Evidence={ECO:0000256|ARBA:ARBA00001792};
CC   -!- COFACTOR:
CC       Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC         Evidence={ECO:0000256|ARBA:ARBA00001961};
CC   -!- SIMILARITY: Belongs to the TPA1 family.
CC       {ECO:0000256|ARBA:ARBA00007443}.
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DR   RefSeq; XP_017734263.1; XM_017878774.1.
DR   AlphaFoldDB; A0A2K6KZJ2; -.
DR   Ensembl; ENSRBIT00000040520.1; ENSRBIP00000016672.1; ENSRBIG00000032356.1.
DR   GeneID; 108533841; -.
DR   CTD; 55239; -.
DR   GeneTree; ENSGT00390000002349; -.
DR   OrthoDB; 5480441at2759; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
DR   GO; GO:0031543; F:peptidyl-proline dioxygenase activity; IEA:UniProt.
DR   Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 2.
DR   InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR   InterPro; IPR019601; Oxoglutarate/Fe-dep_Oase_C.
DR   InterPro; IPR006620; Pro_4_hyd_alph.
DR   InterPro; IPR039558; TPA1/OFD1_N.
DR   PANTHER; PTHR12117; HISTONE ACETYLTRANSFERASE COMPLEX; 1.
DR   PANTHER; PTHR12117:SF0; PROLYL 3-HYDROXYLASE OGFOD1; 1.
DR   Pfam; PF13661; 2OG-FeII_Oxy_4; 1.
DR   Pfam; PF10637; Ofd1_CTDD; 1.
DR   SMART; SM00702; P4Hc; 1.
DR   PROSITE; PS51471; FE2OG_OXY; 1.
PE   3: Inferred from homology;
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   Vitamin C {ECO:0000256|ARBA:ARBA00022896}.
FT   DOMAIN          134..239
FT                   /note="Fe2OG dioxygenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51471"
FT   REGION          333..398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        353..380
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   505 AA;  58504 MW;  9DD64674D5957723 CRC64;
     MNGKRPAEPG PARVGKKGKK EVMAEFSDAV TEETLKTQVA EAWSRRTPFS HEVIVMDMDP
     FLHCVIPNFI QSQDFLEGLQ KELMNLDFHE KYNDLYKFQQ SDDLKKRREP HISALRKILF
     EDFRSWLSDI SKIDLESTID MSCAKYEFTD ALLCHDDELE GRRIAFILYL VPPWDRSLGG
     TLDLYSIDEH FQPKQIVKSL IPSWNKLVFF EVSPVSFHQV SEVLSEEKSR LSISGWFHGP
     SLTRPPNYFE PPIPRSPHIP QDPEKFTKVC EALEHGDVEW SSRGPPNKRF YEKAEESKLP
     EILKECMKLF RSEALFLLLS NFTGLKLHFL APSEEEEEMN DKKEEEAADS TEEGTSHSPP
     EPENNQTAIS NSSQQNNDQT DPEPEENETK KESSVPTCQG ELRRWKTGHY TLIHDHSKAE
     FALDLILYCG CEGWEPEYGG FTSYIAKGED EELLTVNPEN NSLALVYRDR ETLKFVKHIN
     HRSLEQKKTF PNRTGFWDFS FIYYE
//