ID   A0A2K6KZK6_RHIBE        Unreviewed;       513 AA.
AC   A0A2K6KZK6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=Pleckstrin and Sec7 domain containing 3 {ECO:0000313|Ensembl:ENSRBIP00000016687.1};
GN   Name=PSD3 {ECO:0000313|Ensembl:ENSRBIP00000016687.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000016687.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000016687.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000016687.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
CC       {ECO:0000256|ARBA:ARBA00004632}.
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DR   RefSeq; XP_017722763.1; XM_017867274.1.
DR   AlphaFoldDB; A0A2K6KZK6; -.
DR   Ensembl; ENSRBIT00000040535.1; ENSRBIP00000016687.1; ENSRBIG00000032352.1.
DR   GeneID; 108526478; -.
DR   CTD; 23362; -.
DR   GeneTree; ENSGT00940000156591; -.
DR   OrthoDB; 204547at2759; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd13295; PH_EFA6; 1.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041681; PH_9.
DR   InterPro; IPR001605; PH_dom-spectrin-type.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR10663:SF337; PH AND SEC7 DOMAIN-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF15410; PH_9; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   PRINTS; PR00683; SPECTRINPH.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT   DOMAIN          14..199
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   DOMAIN          250..363
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          206..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          464..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..226
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        472..491
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        492..513
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   513 AA;  58061 MW;  78B4497FA6E548D9 CRC64;
     MGSCWCLYGC CNAGVKTTQL EAHSEMGSTE ILEKETPGNL SNGTSSNVEA AKRLAKRLYH
     LDRFKRSDVA KHLGKNNEFS KLVAEEYLKF FDFTGMTLDQ SLRYFFKAFS LVGETQERER
     VLIHFSNRYF YCNPDTIASQ DGVHCLTCAI MLLNTDLHGH NIGKKMTCQE FIANLQGVNE
     GVDFSKDLLK ALYNSIKNEK LEWAVDDEEK KKSPSESTEE KVNGTHPKTI SRIGSTTNPF
     LDIPHDPNAA VYKSGFLARK IHADMDGKKT PRGKRGWKTF YAVLKGTVLY LQKDEYKPEK
     ALSEEDLKNA VSVHHALASK ATDYEKKPNV FKLKTADWRV LLFQTQSQEE MQGWINKINC
     VAAVFSAPPF PAAIGSQKKF SRPLLPATTT KLSQEEQLKS HESKLKQITT ELAEHRSYPP
     DKKVKAKDVD EYKLKDHYLE FEKTRYEMYV SILKEGGKEL LSNDESEAAG LKKSHSSPSL
     NPDTSPITAK VKRNVSERKD HRPETPSIKQ KVT
//