ID A0A2K6L0W8_RHIBE Unreviewed; 3176 AA.
AC A0A2K6L0W8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=WDFY family member 4 {ECO:0000313|Ensembl:ENSRBIP00000017157.1};
GN Name=WDFY4 {ECO:0000313|Ensembl:ENSRBIP00000017157.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000017157.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000017157.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000017157.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_017740998.1; XM_017885509.1.
DR RefSeq; XP_017740999.1; XM_017885510.1.
DR RefSeq; XP_017741000.1; XM_017885511.1.
DR STRING; 61621.ENSRBIP00000017157; -.
DR Ensembl; ENSRBIT00000041010.1; ENSRBIP00000017157.1; ENSRBIG00000032590.1.
DR Ensembl; ENSRBIT00000041023.1; ENSRBIP00000017170.1; ENSRBIG00000032590.1.
DR Ensembl; ENSRBIT00000041027.1; ENSRBIP00000017174.1; ENSRBIG00000032590.1.
DR GeneID; 108537799; -.
DR KEGG; rbb:108537799; -.
DR CTD; 57705; -.
DR GeneTree; ENSGT00940000155684; -.
DR OMA; PREGARN; -.
DR OrthoDB; 47483at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0019882; P:antigen processing and presentation; IEA:Ensembl.
DR GO; GO:0036037; P:CD8-positive, alpha-beta T cell activation; IEA:Ensembl.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF3; WD REPEAT- AND FYVE DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2377..2502
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2519..2813
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2970..3011
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3076..3101
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1829..1866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2303..2338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3099..3120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1829..1846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3176 AA; 353171 MW; 269C90681AC65443 CRC64;
MEAEDLSKAE DRNEDPGSKS EGQLAVPRGG QSPGPTALWD MLERKFLEYQ QLTHKSPTER
QKSLLSLLPL FLKAWEHSVG IICFPSLQRL AEDVSDQLAQ QLQKALVGKP AEQARLAAGQ
LLWWKGDVDQ DGYLLLKSVY VLTGTDSETL GRVAESGLPA LLLQCLYLFF VFPLDKDELF
ESDLQVQRMF VQMLLNICSD YQGLEGLLSG SELQSLLIAT TCLREHSCCF WKEPTFCVLR
AISKAQNLSI IQYLQVTDCV RLSLQNLSRL TDTLPAPEVS EAVSLILGFV KDSYPVSSAL
FLEFENSEGY PLLLKVLLRY DGLTQSEVDP QLEELLGLVV WLTTCGRSEL KVFDSVTYPQ
LEGFKFHHEA SGVTVKNLQA FQVLQNVFHK ASDSVLCIQV LSAIRTMWAW NARNFFLLEW
TLQPISQFVE IMPLKPAPVQ AHFFQLLEAL VFELHYVPHE ILRKVQHLIK ESPEPSCTLM
ALQSILSIAG GDPLFTDIFR DSGLLGLLLA QLRKQAKIMR KSGNKLSTPG VQDPERELTC
VMLKTVVTLL KGSVRNAVVL KDHGMVPFIK IFLDEECYRE ASLSILEQLS AINAEEYMSI
IVGALCSSTQ GELQLKLDLL KSLLRILETP KGRAAFRVSS GFNGLLSLLS DLEGSLQEPP
LQAWGVVSPR QTLELVLYTL CAVSAALHWD PVNDDFFRRN GLFEKLAEDL CLLGCFGALE
EEGALLRSWA DTKARPFADL LGIAFSSSGS LPPRIQSCLQ ILGFLDSMAS GTLHLRGDLK
ESLRAKQGPV VDAQKGEAGS DPQRNFKQWP DLEERMEEGD AAIMHPGVVC IMVRLLPRLY
HEDHPQLSEE IQCSLASHIQ SLVKSEKNRQ VMCEAGMLGT LMASCHRALA TSGSPLHSRL
IRIFEKLASQ AIEPDVLRQF LGLGIPSPLS ATTKLLDSSH AHRGNPGCSG SQTAQGSAEG
PWQAAPDAGL HPGVTQSLQP LGESQDSTTA LQTALSLISM TSPRNLQLQR AALAPSFVEF
DMSVEGYGCL FIPTLSTVMG TSTEYSVSGG IGTGATRPFP PPGGLTFSCW FLISRHGAAT
EGHPLRFLTL VRHLARTEQP FVCFSVSLCP DDLSLVVSTE EKEFQPLDVM EPEDDSEPSA
GRQLQVRCGQ LLACGQWHHL AVVVTKEMKR HCTVSTCLDG QVIGSAKMLY IQALPGPFLS
MDPSAFVDVY GYIATPRVWK QKSSLIWRLG PTYLFEEAIS METLEVINKL GPRYCGNFQA
VHVPGEDLDS EATPLVAEER VSFGLHIASS SITNVADIRN AYNEVDSRLI AKEMNISSRD
NAMPVFLLRN CAGHLSGSLR TIGAVAVGQL GVRVFHSSPA ASSLDFIGGP AILLGLISLA
TDDHTMYAAV KVLHSVLTSN AMCDFLMQHI CGYQIMAFLL RKKASLLNHR IFQLILSVAG
TVELGFRSSI TNTGVFQHIL CNFELWMNTA DNLELSLFSH LLEILQSPRE GPRNAEAAHQ
AQLIPKLVFL FNEPSLIPSK IPTIIGILAC QLRGHFSTQD LLRIGLFVVY TLKPSSVNER
QICVDRALDP SLPAGSQTSG KTIWLRNQLL EMLLSVISSP QLHLSSESKE EMFLKLGPDW
FLLLLQGHLH ASTTVLALKL LLHFLASPSL RTRFRDGLCA GSWVEHSTEG VDIVMDNLKS
HSPLPEQSPC LLPGFRVLND FLAHHVHIPE VYLIVSTFFL QTPLTELTDG PKDSLDAMLQ
WLLQRHHQEE VLQAGLCTEG ALLLLEMLKA TMSQPLAGSE DGAWAQTFPT SVLQFLSLVH
RTYPQDPAWR APEFLQTLAI ATFPLGAQKG AGTESTRNTS SPEAAAEGDS TVEGFQAPTE
THPTRRQLRE FTQLLLRELL LGASSPKQWL PLEVLLEASP DHATSQQKRD FQSKVLLSAM
EIFHMTSRGD TAMLRDGKEP QPSAETAAAP SLANISCFTQ KLVEKLYSGM FSADPRHILL
FILEHIMVVI ETASSQRDTV LSTLYSSLNK VILYCLSKPQ QSLSECLSLL SILGFLQEHW
DVVFATYNSN VSFLLCLMHC LLLLNERSYP EGFGLEPKPR MSTYHQVFLS PNEDMKEKKE
DLPSLSDVQH NIQKTVQTLW QQLVAQRQQT LEDAFKIDLS VKSGEREVKI EEVTPLWEET
MLKAWQHYLA SEKKSLASRS NVAHHSKVTL WSGSLSSAMK LMPGRQAKDP ECKTEDFVSC
IENYRRRGQE LYASLYKDHV QRRKCGNIRA AKAWARIQEQ LFGELGLWNQ GEETTHCCPW
ELDWREGPAR MRKRIKRLSP LEALNSGRHK ESQDKNISQT NAENQDELTP REAEGEPDEV
GVDCTQLTFF PALHESLHSE DFLELCQERQ IILQELLDKE KVTQKFSLVI VQGHLVSEGV
LLFGHQHFYI CENFTLSPTG DVYCTRHCLS NISDPFIFNL CSKDRSTDHY SCQRHSYADM
RELRQARFLL QDMALEIFFH NGYSKFLVFY NSDRSKAFKS FCSFRPSLKG KAASEDPLNL
RRYPGSDRTM LQKWQKRDIS NFEYLMYLNT VAGRTCNDYM QYPVFPWVLA DYTSETLNLA
NPKTFRDLSK PMGAQTKERK LKFIQRFKEV EKTEGDMTVQ CHYYTHYSSA IIVASYLVRM
PPFTQAFCAL QGGGFDVADR MFHSVKSTWE SASRENMSDV RELTPEFFYL PEFLTNCNGV
EFGCMQDGTA LGDVQLPPWA DGDPRKFISL HRQALESDFV SANLHHWIDL IFGYKQQGPA
AVDAVNIFHP YFYGDRVDLS SITDPLIKST ILGFVSNFGQ VPKQLFTKPH PARTAAGKAL
PGKDVSTPVS LPGHPQPFFY SLQSLRPSQV TVKDMYLFSL GSESPKGAIG HIVPTEKTIL
AVERNKLLLP PLWNRTFSWG FDDFSCCLGS YGSDKILMTF ENLAAWGRCL CAVCPSPTTI
VTSGTSTVVC VWELSMTKGR PRGLRLRQAL YGHTQAVTCL AASVTFSLLV SGSQDCTCIL
WDLDHLTHVT RLPMHREGIS AVTISDVSGT IVSCAGAHLS LWNVNGQPLA SITTAWGPEG
AITCCCLIEG PAWDTSQIII TGSQDGMVRV WKTEDVKMSV PGRPAGEEPS SQPPSPRGHK
WEKNLALSRE LDVSIALTGK ASKTSPAVTA LAVSRNQTKL LVGDEKGRIF CWSADG
//
