ID A0A2K6L2W4_RHIBE Unreviewed; 1041 AA.
AC A0A2K6L2W4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Cysteine rich transmembrane BMP regulator 1 {ECO:0000313|Ensembl:ENSRBIP00000017850.1};
GN Name=CRIM1 {ECO:0000313|Ensembl:ENSRBIP00000017850.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000017850.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000017850.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000017850.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6L2W4; -.
DR STRING; 61621.ENSRBIP00000017850; -.
DR Ensembl; ENSRBIT00000041707.1; ENSRBIP00000017850.1; ENSRBIG00000032935.1.
DR GeneTree; ENSGT00940000160910; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 6.20.200.20; -; 6.
DR InterPro; IPR004094; Antistasin-like.
DR InterPro; IPR045813; CRIM1_C.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011061; Hirudin/antistatin.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46439; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR PANTHER; PTHR46439:SF1; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR Pfam; PF02822; Antistasin; 4.
DR Pfam; PF19442; CRIM1_C; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00093; VWC; 6.
DR SMART; SM00121; IB; 1.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 4.
DR SUPFAM; SSF57603; FnI-like domain; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57262; Leech antihemostatic proteins; 2.
DR PROSITE; PS51252; ANTISTASIN; 4.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..1041
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014465225"
FT TRANSMEM 941..961
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..113
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 335..392
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 402..458
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 470..499
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 506..533
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 540..565
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 568..593
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 607..664
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 678..736
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 752..810
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 818..875
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
SQ SEQUENCE 1041 AA; 114162 MW; 65AD46C23A3E9F78 CRC64;
MYLGGGGRGL AGCGHLLVSL LGLLLLLLAR SGTRALVCLP CDESKCEEPR NCPGSIVQGV
CGCCYTCASQ RNESCGGTFG IYGTCDRGLR CVIRPALNGD SLTEYEAGVC EDENWTDDQL
LGFKPCNENL IAGCNIINGK CECNTIRTCS NPFEFPSQDM CLSALKRIEE EKPDCSKARC
EVQFSPRCPE DSVLIEGYAP PGECCPLPSR CVCNPAGCLR KVCQPGNLNI LVSKASGKPG
ECCDLYECKP VFGVDCRTVE CPSVQQTACP PDSYETQVRL TADGCCTLPT RCECLSGLCG
FPVCEVGSTP RIVSRGDGTP GKCCDVFECV NDTKPACIFN NVEYYDGDMF RMDNCRFCRC
QGGVAICFTA QCGEINCERY YVPEGECCPV CEDPVYPFNN PAGCYANGLI LAHGDRWRED
DCTFCQCVNG ERHCVATVCG QTCTNPVKVP GECCPVCEEP TIITVDPPAC GELSNCTLTG
KDCINGFKRD HNGCRTCQCI NSEELCSERK QGCTLDCPFG FLTDAQNCEM CECRPRPKKC
RPIICDKYCP LGLLKNKHGC DICRCKKCPE LSCSKICPLG FQQDSHGCLI CKCREVSASA
GPPILSGTCL TVDGHHHKNE ESWHDGCREC YCLNGREMCA LITCPVPACG NPTIHPGQCC
PSCADDFVVQ KPELSTPSIC HAPGGEYFVE GETWNIDSCT QCTCHSGRVL CETEVCPPLL
CQNPSRTQDS CCPQCTDQPF RPSLSRNNSV PNYCKNDEGD IFLAAESWKP DVCTSCICID
SVISCFSESC PSVSCERPVL RKGQCCPYCI EDTIPKKVVC HFSGKAYADE ERWDLDSCTH
CYCLQGQTLC STVSCPPLPC VEPINVEGSC CPMCPEMYAP EPTNIPIEKT NHRGEVDLEV
PLWPTPSEND IVHLPRDMGH LQVDYRDNRL HPSGDSSLDS IASVVVPIII CLSIIIAFLF
INQKKQWIPL LCWYRTPTKP SSLNNQLVSV DCKKGTRVQV DSSQRMLRIA EPDARFSGFY
SMQKQNHLQA DNFYQTKEKL N
//
