ID A0A2K6L5J4_RHIBE Unreviewed; 240 AA.
AC A0A2K6L5J4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Transmembrane p24 trafficking protein 6 {ECO:0000313|Ensembl:ENSRBIP00000018794.1};
GN Name=TMED6 {ECO:0000313|Ensembl:ENSRBIP00000018794.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000018794.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000018794.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000018794.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003827}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003827}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family.
CC {ECO:0000256|ARBA:ARBA00007104, ECO:0000256|RuleBase:RU003827}.
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DR RefSeq; XP_017706254.1; XM_017850765.1.
DR AlphaFoldDB; A0A2K6L5J4; -.
DR STRING; 61621.ENSRBIP00000018794; -.
DR Ensembl; ENSRBIT00000042661.1; ENSRBIP00000018794.1; ENSRBIG00000033389.1.
DR GeneID; 108514503; -.
DR KEGG; rbb:108514503; -.
DR CTD; 146456; -.
DR GeneTree; ENSGT00390000010961; -.
DR OMA; WHFAHQG; -.
DR OrthoDB; 5300317at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProt.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR PANTHER; PTHR22811; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22811:SF45; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 6; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003827};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..240
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014369190"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..138
FT /note="GOLD"
FT /evidence="ECO:0000259|PROSITE:PS50866"
SQ SEQUENCE 240 AA; 27775 MW; 89CAD7835A39C2EA CRC64;
MSPLLFGAGL VVLNLVTSAR SQKTEPLSGS GDQPLFRGAD RYDFAIMIPP GGTECFWQFA
HQTGYFYFSY EVQRTMGMSH DRHVAATAHN PQGFLIDTSQ DVRGQINFST QETGFYQLCL
NNQHNHFGSV QVYLNFGVFY EGPETDHKQK ERKQLNDTLD AIEDSTQKVQ NNIFHMWRYY
NFARMRKMAD FFLTHSNYNY VNWWSTAQSL VIILSGILQL YFLKRLFNVP TTTDTKKPRC
//
