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Database: UniProt
Entry: A0A2K6L5S0_RHIBE
LinkDB: A0A2K6L5S0_RHIBE
Original site: A0A2K6L5S0_RHIBE 
ID   A0A2K6L5S0_RHIBE        Unreviewed;       370 AA.
AC   A0A2K6L5S0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Protein-tyrosine sulfotransferase {ECO:0000256|ARBA:ARBA00013262, ECO:0000256|RuleBase:RU365018};
DE            EC=2.8.2.20 {ECO:0000256|ARBA:ARBA00013262, ECO:0000256|RuleBase:RU365018};
GN   Name=TPST1 {ECO:0000313|Ensembl:ENSRBIP00000018865.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000018865.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000018865.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000018865.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Catalyzes the O-sulfation of tyrosine residues within acidic
CC       motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as
CC       cosubstrate. {ECO:0000256|ARBA:ARBA00003886,
CC       ECO:0000256|RuleBase:RU365018}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine
CC         3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein];
CC         Xref=Rhea:RHEA:16801, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:11688,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:46858, ChEBI:CHEBI:58339,
CC         ChEBI:CHEBI:58343, ChEBI:CHEBI:65286; EC=2.8.2.20;
CC         Evidence={ECO:0000256|ARBA:ARBA00000411,
CC         ECO:0000256|RuleBase:RU365018};
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004323}.
CC   -!- SIMILARITY: Belongs to the protein sulfotransferase family.
CC       {ECO:0000256|ARBA:ARBA00009988, ECO:0000256|RuleBase:RU365018}.
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DR   RefSeq; XP_017750153.1; XM_017894664.1.
DR   RefSeq; XP_017750154.1; XM_017894665.1.
DR   STRING; 61621.ENSRBIP00000018867; -.
DR   Ensembl; ENSRBIT00000042732.1; ENSRBIP00000018865.1; ENSRBIG00000033422.1.
DR   Ensembl; ENSRBIT00000042734.1; ENSRBIP00000018867.1; ENSRBIG00000033422.1.
DR   GeneID; 108543856; -.
DR   KEGG; rbb:108543856; -.
DR   CTD; 8460; -.
DR   GeneTree; ENSGT00390000006030; -.
DR   OMA; LNDFRQC; -.
DR   OrthoDB; 5391764at2759; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008476; F:protein-tyrosine sulfotransferase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR026634; TPST-like.
DR   PANTHER; PTHR12788:SF4; PROTEIN-TYROSINE SULFOTRANSFERASE 1; 1.
DR   PANTHER; PTHR12788; PROTEIN-TYROSINE SULFOTRANSFERASE 2; 1.
DR   Pfam; PF13469; Sulfotransfer_3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365018}.
SQ   SEQUENCE   370 AA;  42186 MW;  16ABEF33D515ECD3 CRC64;
     MVGKLKQNLL LACLVISSVT VFYLGQHAME CHHRIEERSQ PVKLESTRTT VRTGLDLKAN
     KTFAYHKDMP LIFIGGVPRS GTTLMRAMLD AHPDIRCGEE TRVIPRILAL KQMWSRSSKE
     KIRLDEAGVT DEVLDSAMQA FLLEIIVKHG EPAPYLCNKD PFALKSLTYL ARLFPNAKFL
     LMVRDGRASV HSMISRKVTI AGFDLNSYRD CLTKWNRAIE TMYNQCMEVG YKKCMLVHYE
     QLVLHPERWM RTLLKFLQIP WNHSVLHHEE MIGKAGGVSL SKVERSTDQV IKPVNVAALS
     KWVGKIPPDV LQDMAVIAPM LAKLGYDPYA NPPNYGKPDP KILENTRRVY KGEFQLPDFL
     KEKPQTEQVE
//
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