ID   A0A2K6L6X4_RHIBE        Unreviewed;       134 AA.
AC   A0A2K6L6X4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=choline-phosphate cytidylyltransferase {ECO:0000256|ARBA:ARBA00026101};
DE            EC=2.7.7.15 {ECO:0000256|ARBA:ARBA00026101};
GN   Name=PCYT1A {ECO:0000313|Ensembl:ENSRBIP00000019271.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000019271.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000019271.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000019271.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Catalyzes the key rate-limiting step in the CDP-choline
CC       pathway for phosphatidylcholine biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00025501}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=CTP + H(+) + phosphocholine = CDP-choline + diphosphate;
CC         Xref=Rhea:RHEA:18997, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:37563, ChEBI:CHEBI:58779, ChEBI:CHEBI:295975;
CC         EC=2.7.7.15; Evidence={ECO:0000256|ARBA:ARBA00024554};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18998;
CC         Evidence={ECO:0000256|ARBA:ARBA00024554};
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis;
CC       phosphatidylcholine from phosphocholine: step 1/2.
CC       {ECO:0000256|ARBA:ARBA00025706}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K6L6X4; -.
DR   Ensembl; ENSRBIT00000043141.1; ENSRBIP00000019271.1; ENSRBIG00000033613.1.
DR   GeneTree; ENSGT00940000157384; -.
DR   UniPathway; UPA00753; UER00739.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0004105; F:choline-phosphate cytidylyltransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   InterPro; IPR004821; Cyt_trans-like.
DR   InterPro; IPR045049; Pcy1-like.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR   PANTHER; PTHR10739:SF19; CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE A; 1.
DR   PANTHER; PTHR10739; CYTIDYLYLTRANSFERASE; 1.
DR   Pfam; PF01467; CTP_transf_like; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT   DOMAIN          80..111
FT                   /note="Cytidyltransferase-like"
FT                   /evidence="ECO:0000259|Pfam:PF01467"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   134 AA;  14733 MW;  F5067BDD3F17DAD9 CRC64;
     MDAQCSAKVN ARKRRKEAPG PNGATEEDGV PFKVQRCAVG LRQPAPFSDE IEVDFSKPYV
     RVTMEEASRG TPCERPVRVY ADGIFDLFHS GHARALMQAK NLFPNTYLIV GDFSPVGEDG
     CSPKQWEKMG EVGG
//