ID A0A2K6L7R0_RHIBE Unreviewed; 403 AA.
AC A0A2K6L7R0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Tyrosine hydroxylase {ECO:0000313|Ensembl:ENSRBIP00000019537.1};
GN Name=TH {ECO:0000313|Ensembl:ENSRBIP00000019537.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000019537.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000019537.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000019537.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR AlphaFoldDB; A0A2K6L7R0; -.
DR Ensembl; ENSRBIT00000043411.1; ENSRBIP00000019537.1; ENSRBIG00000033743.1.
DR GeneTree; ENSGT00950000182885; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004511; F:tyrosine 3-monooxygenase activity; IEA:InterPro.
DR GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR CDD; cd04930; ACT_TH; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 2.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR InterPro; IPR049321; TH_ACT.
DR InterPro; IPR021164; Tyrosine_hydroxylase_CS.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF18; TYROSINE 3-MONOOXYGENASE; 1.
DR Pfam; PF00351; Biopterin_H; 2.
DR Pfam; PF21417; TH_ACT; 1.
DR Pfam; PF12549; TOH_N; 2.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 2.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601273-2};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 151..232
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT DOMAIN 233..403
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 236
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 241
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 281
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ SEQUENCE 403 AA; 44899 MW; 714E0ED44B0D1B21 CRC64;
MPTPDATTPQ AKGFRRAVSE LDAKQAEAIM SPRFIGRRQS LIEDARKERE AAVAAAAAAA
PSEPGDPLEA VAFEEKEGKA VLNLLFSPRA TKPSALSRAV KVFETFEAKI HHLETRPAQR
LRAGGPHLEY FVRLEVPRGD LAALLSGVRQ VSEDVRSPAE PKVPWFPRKV SELDKCHHLV
TKFDPDLDLD HPGFSDQVYR QRRKLIAEIA FQYRHGDPIP RVEYTAEEIA TWDCCHELLG
HVPMLADRTF AQFSQDIGLA SLGASDEEIE KLSTLYWFTV EFGLCKQNGE VKAYGAGLLS
SYGELLHCLS EEPEIRAFDP EAAAVQPYQD QTYQSVYFVS ESFSDAKDKL RSYASRIQRP
FSVKFDPYTL AIDVLDSPQA VRRSLEGVQD ELDTLAHALS AIG
//