ID   A0A2K6L803_RHIBE        Unreviewed;       698 AA.
AC   A0A2K6L803;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=DNA-binding protein RFX2 {ECO:0000256|ARBA:ARBA00039910};
DE   AltName: Full=Regulatory factor X 2 {ECO:0000256|ARBA:ARBA00042136};
GN   Name=RFX2 {ECO:0000313|Ensembl:ENSRBIP00000019618.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000019618.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000019618.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000019618.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_017722493.1; XM_017867004.1.
DR   RefSeq; XP_017722498.1; XM_017867009.1.
DR   AlphaFoldDB; A0A2K6L803; -.
DR   Ensembl; ENSRBIT00000043492.1; ENSRBIP00000019618.1; ENSRBIG00000033776.1.
DR   GeneID; 108526306; -.
DR   CTD; 5990; -.
DR   GeneTree; ENSGT01050000244879; -.
DR   OMA; QFIDMSH; -.
DR   OrthoDB; 2915941at2759; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR003150; DNA-bd_RFX.
DR   InterPro; IPR039779; RFX-like.
DR   InterPro; IPR007668; RFX1_trans_act.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12619:SF17; DNA-BINDING PROTEIN RFX2; 1.
DR   PANTHER; PTHR12619; RFX TRANSCRIPTION FACTOR FAMILY; 1.
DR   Pfam; PF04589; RFX1_trans_act; 1.
DR   Pfam; PF02257; RFX_DNA_binding; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51526; RFX_DBD; 1.
PE   4: Predicted;
KW   Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT   DOMAIN          174..249
FT                   /note="RFX-type winged-helix"
FT                   /evidence="ECO:0000259|PROSITE:PS51526"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          267..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          664..698
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        283..307
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   698 AA;  77219 MW;  D753477CF991AD06 CRC64;
     MQNSEGGADS PASVALRPSA AAPPVPASPQ RVLVQAASSA PKGAQMQPIS LPRVQQVPQQ
     VQPAQHVYPA QVQYVEGGDA IYTNGAIRTA YTYNPEPQMY APSSAASYFE APGGAQVTVA
     ASSPPAVPSH SMVGITMDVG GSPIVSSTGA YLIHGGMDST RHSLAHTSRS SPATLQWLLD
     NYETAEGVSL PRSSLYNHYL RHCQEHKLDP VNAASFGKLI RSVFMGLRTR RLGTRGNSKY
     HYYGIRLKPD SPLNRLQEDT QYMAMRQQPM HQKPRYRPAQ KTDSLGDSGS HSSLHSTPEQ
     TMAAQSQHHQ QYIDVSHVFP EFPAPDLGSV LLQDGVTLHD VKALQLVYRR HCEATVDVVM
     NLQFHYIEKL WLSFWNSKAS SSDGPTSLPA SDEDAEGAVL PKDKLISLCQ CDPILRWMRS
     CDHILYQALV EILIPDVLRP VPSTLTQAIR NFAKSLEGWL TNAMSDFPQQ VIQTKVGVVS
     AFAQTLRRYT SLNHLAQAAR AVLQNTSQIN QMLSDLNRVD FANVQEQASW VCQCEESVVQ
     RLEQDFKLTL QQQSSLDQWA SWLDSVVTQV LKQHAGSPSF PKAARQFLLK WSFYSSMVIR
     DLTLRSAASF GSFHLIRLLY DEYMFYLVEH RVAEATGETP IAVMGEFNDL ASLSLTLLDK
     DDMRDEQRGS EAGPDAHSLG EPLVKRERSD PNHSLQGI
//