ID   A0A2K6L8N0_RHIBE        Unreviewed;       456 AA.
AC   A0A2K6L8N0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   SubName: Full=Forkhead box P3 {ECO:0000313|Ensembl:ENSRBIP00000019889.1};
GN   Name=FOXP3 {ECO:0000313|Ensembl:ENSRBIP00000019889.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000019889.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000019889.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000019889.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR   RefSeq; XP_017716677.1; XM_017861188.1.
DR   AlphaFoldDB; A0A2K6L8N0; -.
DR   STRING; 61621.ENSRBIP00000019889; -.
DR   Ensembl; ENSRBIT00000043767.1; ENSRBIP00000019889.1; ENSRBIG00000033932.1.
DR   GeneID; 108521365; -.
DR   CTD; 50943; -.
DR   GeneTree; ENSGT00940000161807; -.
DR   OrthoDB; 5385885at2759; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0035035; F:histone acetyltransferase binding; IEA:Ensembl.
DR   GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR   GO; GO:0051525; F:NFAT protein binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR   GO; GO:0032693; P:negative regulation of interleukin-10 production; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032703; P:negative regulation of interleukin-2 production; IEA:Ensembl.
DR   GO; GO:0032713; P:negative regulation of interleukin-4 production; IEA:Ensembl.
DR   GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl.
DR   GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; IEA:Ensembl.
DR   GO; GO:0032689; P:negative regulation of type II interferon production; IEA:Ensembl.
DR   GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; IEA:Ensembl.
DR   GO; GO:0045066; P:regulatory T cell differentiation; IEA:Ensembl.
DR   GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR   Gene3D; 1.20.5.340; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR032354; FOXP-CC.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR   PANTHER; PTHR45796:SF5; FORKHEAD BOX PROTEIN P3; 1.
DR   Pfam; PF00250; Forkhead; 2.
DR   Pfam; PF16159; FOXP-CC; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT   DOMAIN          302..448
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        302..448
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   456 AA;  49876 MW;  8BAB28B29C9B2D64 CRC64;
     MPNPRPGKPS APSLALGPSP GASPSWRAAP KASDLMGARG PGGTFQGRDL RGGAHASSSS
     LNPMPPSQLQ LSTVDAHART PVLQVHPLES PAMISLPPPT TATGVFSLKA RPGLPPGINV
     ASLEWVSREP ALLCTFPNPG APRKDSTLSA MPQSSYPLLA NGVCKWPGCE KVFEEPEDFL
     KHCQADHLLD EKGRAQCLLQ REMVQSLEQQ LVLEKEKLSA MQAHLAGKMA LTKASSVASS
     DKGSCCIVAA GSQGSAVPAW SGPREAPDSL FAVRRHLWGS HGNSTFPEFL HNMDYFKFHN
     MRPPFTYATL IRWAILEAPE KQRTLNEIYH WFTRMFAFFR NHPATWKVSS SEVAVAGMAS
     SATAAQSGQT WGWAYRHIGE EWDVGRWWWL LASEVDAHLI PVPGLPQNAI RHNLSLHKCF
     VRVESEKGAV WTVDELEFRK KRSQRPSRCS NPTPGP
//