ID A0A2K6LAW6_RHIBE Unreviewed; 3411 AA.
AC A0A2K6LAW6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=CUB and Sushi multiple domains 2 {ECO:0000313|Ensembl:ENSRBIP00000020657.1};
GN Name=CSMD2 {ECO:0000313|Ensembl:ENSRBIP00000020657.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000020657.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000020657.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000020657.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR Ensembl; ENSRBIT00000044539.1; ENSRBIP00000020657.1; ENSRBIG00000034267.1.
DR GeneTree; ENSGT00940000159768; -.
DR OMA; TECLDTG; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 26.
DR CDD; cd00041; CUB; 12.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 26.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 13.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656:SF6; CUB AND SUSHI DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR Pfam; PF00431; CUB; 13.
DR Pfam; PF00084; Sushi; 26.
DR SMART; SM00032; CCP; 26.
DR SMART; SM00042; CUB; 13.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 26.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 14.
DR PROSITE; PS01180; CUB; 12.
DR PROSITE; PS50923; SUSHI; 26.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3332..3353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..134
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 138..242
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 277..338
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 341..458
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 461..518
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 520..628
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 631..692
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 694..802
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 807..864
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 866..976
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 979..1038
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1040..1148
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1151..1211
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1312..1372
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1374..1482
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1485..1546
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1548..1648
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1654..1715
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1717..1825
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1828..1887
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1889..1997
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2042..2101
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2103..2214
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2213..2274
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2276..2387
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2387..2449
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2450..2511
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2512..2576
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2577..2634
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2635..2692
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2693..2750
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2754..2811
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2812..2870
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2871..2930
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2931..2988
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2989..3046
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3050..3108
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3109..3168
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 489..516
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 835..862
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2605..2632
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2663..2690
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2721..2748
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2782..2809
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2841..2868
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2959..2986
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3017..3044
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3079..3106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 3411 AA; 371838 MW; 9574AD13A0635C98 CRC64;
RNCQTIFQSN CMFLHFYQHC MRNPGFLYHH RLTGFQLPAT IVSAATTLSL RLISDYAVSA
QGFHATYEVL PSHTCGNPGR LPNGIQQGST FNLGDKVRYS CNPGFFLEGH AVLTCHAGSE
NSATWDFPLP SCRADDACGG TLRGQSGIIT SPHFPSEYHN NADCTWTILA ELGDTIALVF
IDFQLEDGYD FLEVTGTEGS SLWFTGASLP APVISSKNWL RLHFTSDGNH RQRGFSAQYQ
VKKQIELKSR GVKLMPSKDS SQKTSVLTQV GVSQGHNMCP DPGIPERGKR LGSDFRLGSS
IQFTCNEGYD LQGSKRITCM KVSDMFAAWS DHRPVCRARM CDAHLRGPSG IITSPNFPIQ
YDNNAHCVWI ITALNPAKVI KLAFEEFDLE RGYDTLTVGD GGQDGDQKTH TSKYLSPASL
TGTSVPDLIV STNHQMWLLF QTDGSGSSLG FKASYEEIEQ GSCGDPGIPA YGRREGSRFR
HGDTLKFECQ PAFELVGQKA ITCQKNNQWS AKKPGCVFSC FFNFTSPSGI VLSPNYPEDY
GNHLHCVWLI LARPESRIHL AFNDIDVEPQ FDFLVIKDGA TAEAPVLGTF SGNQLPSSIT
SSGHVARLEF QTDHSTGKRG FNITFTTFRH NECPDPGVPV NGKRFGDSLQ LGSSISFLCD
EGFLGTQGSE TITCVLKEGS VVWNSAVLRC EAPCGGHLTS PSGTILSPGW PGFYKDALSC
AWVIEAQPGY PIKITFDRFK TEVNYDTLEV RDGRTYSAPL IGVYHGTQVP QFLISTSNYL
YLLFSTDKSH SDIGFQLRYE TITLQSDHCL DPGIPVNGQR HGNDFYVGAL VTFSCDSGYT
LSDGEPLECE PNFQWSRALP SCEALCGGFI QGSSGTILSP GFPDFYPNNL NCTWIIETSH
GKGVFFTFHT FHLESGHDYL LITENGSFTQ PLRQLTGSRL PAPISAGLYG NFTAQVRFIS
DFSMSYEGFN ITFSEYDLEP CEEPEVPAYS IRKGLQFGVG DTLTFSCFPG YRLEGTARIT
CLGGRRRLWS SPLPRCVAEC GNSVTGTQGT LLSPNFPVNY NNNHECIYSI QTQPGTGIQL
KARAFELSEG DVLKVYDGNN NSARLLGVFS RSEMMGVTLN STSSSLWLDF ITDAENTSKG
FELQFSSFEL IKCEDPGTPQ FGYKVHDEGH FAGSSVSFSC DPGYSLRGSE ELLCLSGERR
TWDRPLPTCV GRRALPLPHA PEPGGHLLGL NPLVNRHHGS LHFLVFDTEE VHDVLRIWDG
PVESGVLLKE LSGPALPKDL HSTFNSVVLQ FSTDFFTSKQ GFAIQFSVST ATSCNDPGIP
QNGSRSGDSW EAGDSTVFQC DPGYALQGSA EISCVKIENR FFWQPSPPTC IAPCGGDLTG
PSGVILSPNY PEPYPPGKEC DWKVTVSPDY VIALVFNIFN LEPGYDFLHI YDGRDSLSPL
IGSFYGSQLP GRIESSSNSL FLAFRSDASV SNAGFVIDYT ENPRESCFDP GSIKNGTRVG
SDLKLGSSVT YYCHAGYEVE GASTLSCILG PDGKPVWNNP RPVCTAPCGG QYVGSDGVNY
TSGQICLYFV TVPKDYVVFG QFAFFHTALN DVVEVHDGHS QHSRLLSSLS GSHTGESLPL
ATSNQVLIKF SAKGLAPARG FHFVYQAVPR TSATQCSSVP EPRYGKRLGN DFSVGAIVRF
ECNSGYALQG SPEIECLPVP GALAQWNVSA PTCVVPCGGN LTERRGTILS PGFPEPYLNS
LNCVWKIVVP EGAGIQIQVI SFVTEQNWDS LEVFDGADNT VTMLGSFSGT TVPALLNSTS
NQLYLHFYSD ISVSAAGFHL EYKTVGLSSC PEPAVPSNGV KTGERYLVND VVSFQCEPGY
ALQGHAHISC MPGTVRRWNY PPPLCIAQCG GTVEEMEGVI LSPGFPGNYP SNMDCSWKIA
LPVGFGAHIQ FLNFSTEPNH DYIEIRNGPY ETSRMMGRFS GNELPSSLLS TSHETTVYFH
SDHSQNRPGF KLEYQDLTYS HQISSFLRGF DLSELERTNS TPPVAASYVW ELDPGREAYE
LQECPDPEPF ANGIVRGAGY NVGQSVTFEC LPGYQLTGHP VLTCQHGTNR NWDHPLPKCE
VPCGGNITSS NGTVYSPGFP SPYSSSQDCV WLITVPIGHG VRLNLSLLQT EPSGDFITIW
DGPQQTAPRL GVFTRSMAKK TVHSSSNQVL LKFHRDAATG GIFAIAFSAY PLTKCPPPTI
LPNAEVVTEN EEFNIGDIVR YRCLPGFTLV GNEILTCKLG TYLQFEGPPP ICEVHCPTNE
LLTDSTGVIL SQSYPGSYPQ FQTCSWLVRV EPDYNISLTV EYFLSEKQYD EFEIFDGPSG
QSPLLKALSG NYSAPLIVTS SSNSVYLRWS SDHAYNRKGF KIRYSAPYCS LPRAPLHGFI
LGQTSTQPGG SIHFGCNAGY RLVGHSMAIC TRHPQGYHLW SEAIPLCQAL SCGLPEAPKN
GMVFGKEYTV GTKAVYSCSE GYHLQAGAEA AAECLDTGLW SNHNVPPQCV PVTCPDVSSI
SVEHGRWRLI FETQYQFQAQ LMLICDPGYY YTGQRVIRCQ ANGKWSLGDS TPTCQIISCG
ELPVPPNGHR IGTLSVYGAT AIFSCNSGYT LVGSRVRECM ANGLWSGSEV RCLAGHCGTP
EPIVNGHING ENYSYRGSVV YQCNAGFRLI GMSVRICQQD HHWSGKTPFC VLVSCGHPGS
PPHSQMSGDS YTVGAVVRYG CTGKRTLVGN STRMCGLDGH WTGSLPHCSG TSMGVCGDPG
IPAHGIRLGD SFDPGTVMRF SCEAGHVLRG SSERTCQANG SWSGSQPECG VISCGNPGTP
SNARVVFSDG LVFSSSIVYE CREGYYATGL LSRHCSVNGT WTGSDPECLV INCGDPGIPA
NGLRLGNDFR YNKTVTYHCV PGYMMESHRV SVLSCTKDRT WNGTKPVCKA LMCKPPPLIP
NGKVVGSDFM WGSSVTYACL EGYQLSLPAV LTCEGNGSWT GELPQCFPVF CGDPGVPPRG
RREDRGFSYR SSVSFSCHPP LVLVGSPRRF CQSDGTWSGT QPSCIDPTLT TCADPGVPQF
GIQNNSQGYQ VGSTVLFRCQ KGYLLQGSTT RTCLPNLTWS GTPPDCVPHH CRQPETPTHA
NVGALDLPSM GYTLIYSCQE GFSLKGGSEH RTCKADGSWT GKPPICLEVR PSGRPINTAR
EPPLTQALIP GDVFAKNSLW KGAYEYQGKK QPAMLRVTGF QAANSKVNAT MIDHSGVELH
LAGTYKKEDF HLLLQVYQIT GPVEIFVNKF RDDHWALDGH VSSESSGGTF IYQGSVKGQG
FGQFGFQRLD LRLLESDPES IGRHFASNSS SVAAAILVPF IALIIAGFVL YLYKHRRRPK
VPFNGYAGHE NTNNTNVRAT FENPMYDRNI QPTDIMASEA EFTVSTVCTA V
//
