ID   A0A2K6LBM8_RHIBE        Unreviewed;      1029 AA.
AC   A0A2K6LBM8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   RecName: Full=Alpha-2-macroglobulin domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000020935.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000020935.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000020935.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR   AlphaFoldDB; A0A2K6LBM8; -.
DR   Ensembl; ENSRBIT00000044817.1; ENSRBIP00000020935.1; ENSRBIG00000034447.1.
DR   GeneTree; ENSGT00940000158779; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.50.10.20; -; 2.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.60.120.1540; -; 1.
DR   Gene3D; 2.60.40.1930; -; 2.
DR   Gene3D; 2.60.40.1940; -; 1.
DR   Gene3D; 6.20.50.160; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR041555; MG3.
DR   InterPro; IPR040839; MG4.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   PANTHER; PTHR11412:SF174; OVOSTATIN HOMOLOG 1-RELATED; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF17791; MG3; 1.
DR   Pfam; PF17789; MG4; 1.
DR   Pfam; PF07678; TED_complement; 2.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900}.
FT   DOMAIN          251..380
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          475..565
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
FT   DOMAIN          947..1029
FT                   /note="Alpha-macroglobulin receptor-binding"
FT                   /evidence="ECO:0000259|SMART:SM01361"
SQ   SEQUENCE   1029 AA;  116565 MW;  D0F4D6E38594BC0C CRC64;
     RIFQWQNVTS FRNITQLSFQ LISEPMFGDY WIVVKKNSGK TVTHQFAVKR YVLPKFEVTV
     SAPETVTISD DEFQVDVCAK YTFGQPVQGK TQIQVCREYF SSSNCEKNDN EICEQFIAQT
     CFTLLCSSFL TGVQIGENTS VFITQLLGTV NFENMDTFYR RGISYFGTLK FSGPDNVPMV
     NKLLQLELND EFIGNYTTDE NGEAQFSIDT SDIFDPEFNL KSCYLPSWLT PQYSDASFLV
     SRFYSRTNSF LKIVPEPKQL ECNQQKVVTV LYSLNSEAYE DDSNVKFFYL VTWNGNFSFA
     INVSADLAPV AVLFVYTLHP SGEIVADSVR FQIDKCFKHK VNIKFSEEQG LPGSNASLYL
     QAAPDSFCAL RAVDRSVLLL KSEQQLSAES VYNMVPSIEL YGYFYRGLHL DDSKEDPCIP
     QRDMFYNGLY YTPVSNYGDG DIYNIVMVRS LRILENISSQ FLAIIQTVRT NFPETWIWDL
     VSVDSSGSAN LSFLIPDTIT QWEASGFCVN GDVGFGVSST TTLEVSQPFF IEIASPFSVV
     QNEQFDLIVN VFNYLDTCVE VSCKVNITVV AEAKQSNACP NEGMERQKLN WKDTVVKSFL
     VEVWIWDILG LAMQNLVVLQ MPYGSGEQNA ALLASDTYVL DYLKSTEQLT EEVQSKAFFL
     LSNGYQRQLS FKNSDGSYSV FWQQNQKGSI WLSALTFKTL ERMKNYVFID ENVQKQTLIW
     LSSQQKMNGC FKNDGQLFNH FPALRSALFC LEEALDSGVT NGYNHAILAY TFALAGEEQK
     VESLLQTLDQ SATKINNVIY WERERKPQTE EFPSFTPWAP SAETEKTCYV LLAVISRKIP
     DLTYASKIVQ WLAQQMNSHG GFSSTQVINV GLILIALTFS KNQNTVTFSS EGSSKTFRVN
     SDNRLLVQHS ELTKAPGEYT VDVEGHGCTF IQCFLKLFRY TGIHNKSSIV VTDVKMLSGF
     TPAMSSIEEV SNRSLICQHK DSSIEYKNKI NTCLFHFSVE QSNLVFNIQP APVMVYDYYE
     KGRQATAMP
//