ID   A0A2K6LBW1_RHIBE        Unreviewed;       338 AA.
AC   A0A2K6LBW1;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Syndecan {ECO:0000256|RuleBase:RU000649};
GN   Name=SDC1 {ECO:0000313|Ensembl:ENSRBIP00000021003.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000021003.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000021003.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000021003.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Cell surface proteoglycan. {ECO:0000256|RuleBase:RU000649}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC       ECO:0000256|RuleBase:RU000649}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000649}.
CC       Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
CC   -!- SIMILARITY: Belongs to the syndecan proteoglycan family.
CC       {ECO:0000256|ARBA:ARBA00005343, ECO:0000256|RuleBase:RU000649}.
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DR   AlphaFoldDB; A0A2K6LBW1; -.
DR   STRING; 61621.ENSRBIP00000021003; -.
DR   Ensembl; ENSRBIT00000044886.1; ENSRBIP00000021003.1; ENSRBIG00000034487.1.
DR   GeneTree; ENSGT00940000161171; -.
DR   OMA; STWKDMA; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0038024; F:cargo receptor activity; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0048627; P:myoblast development; IEA:Ensembl.
DR   GO; GO:1903543; P:positive regulation of exosomal secretion; IEA:Ensembl.
DR   GO; GO:1903553; P:positive regulation of extracellular exosome assembly; IEA:Ensembl.
DR   GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl.
DR   GO; GO:0055002; P:striated muscle cell development; IEA:Ensembl.
DR   InterPro; IPR003585; Neurexin-like.
DR   InterPro; IPR001050; Syndecan.
DR   InterPro; IPR027789; Syndecan/Neurexin_dom.
DR   InterPro; IPR030479; Syndecan_CS.
DR   PANTHER; PTHR10915; SYNDECAN; 1.
DR   PANTHER; PTHR10915:SF5; SYNDECAN-1; 1.
DR   Pfam; PF01034; Syndecan; 1.
DR   SMART; SM00294; 4.1m; 1.
DR   PROSITE; PS00964; SYNDECAN; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW   ECO:0000256|RuleBase:RU000649};
KW   Heparan sulfate {ECO:0000256|ARBA:ARBA00023207,
KW   ECO:0000256|RuleBase:RU000649};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteoglycan {ECO:0000256|ARBA:ARBA00022974,
KW   ECO:0000256|RuleBase:RU000649};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000649};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        280..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          303..321
FT                   /note="Neurexin/syndecan/glycophorin C"
FT                   /evidence="ECO:0000259|SMART:SM00294"
FT   REGION          1..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          312..338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..121
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..179
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   338 AA;  34857 MW;  3CFFF27AE0A0E9F9 CRC64;
     LPPLQSLSRA APPHPGPGQK GVRLGPTTQG SAELKGCEPR LAGPTAPEGE QIVATNVPPE
     DQDGSGDDSD NFSGSGAGAL QDITLSQQTP STWKDTWLLT ATPTSPEPTG LEATAASTST
     LPAGEGPKEG EAVVLLEVEP GLTAREQEAT PQPTETTQLP TTHQAPTARA TTAQEPATSH
     PHRDMQPGHH ETSAPAGPGQ ADLHTPRTGD GGPSATERAA EDGASSQLPA AEGSGEQDFT
     FETSGENTAI VAVEPDHRNQ SPVDPGATGA SQGLLDRKEV LGGIIAGGLV GLIFAVCLVG
     FMLYRMKKKD EGSYSLEEPK QANGGAYQKP TKQEEFYA
//