ID A0A2K6LEN3_RHIBE Unreviewed; 1034 AA.
AC A0A2K6LEN3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Mtr4 exosome RNA helicase {ECO:0000313|Ensembl:ENSRBIP00000021962.1};
GN Name=MTREX {ECO:0000313|Ensembl:ENSRBIP00000021962.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000021962.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000021962.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000021962.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6LEN3; -.
DR STRING; 61621.ENSRBIP00000021962; -.
DR Ensembl; ENSRBIT00000045849.1; ENSRBIP00000021962.1; ENSRBIG00000034930.1.
DR GeneTree; ENSGT00940000156183; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IEA:Ensembl.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0031499; C:TRAMP complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0000460; P:maturation of 5.8S rRNA; IEA:Ensembl.
DR GO; GO:0006401; P:RNA catabolic process; IEA:Ensembl.
DR CDD; cd18024; DEXHc_Mtr4-like; 1.
DR CDD; cd13154; KOW_Mtr4; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 148..304
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 388..560
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1034 AA; 117485 MW; F1F9691732B482FF CRC64;
MADAFGDELF SVFESDSTNE AGTKKDKEKD KGKWKGPPGS ADKAGKRFDG KLQSEPTNNG
KNKRDVDFEG TDEPIFGKKP RIEESITEDL SLADLMPRVK VQSVETVEGC THEVALPADE
DYLPLKPRVG KAAKEYPFIL DAFQREAIQC VDNNQSVLVS AHTSAGKTVC AEYAIALALR
EKQRVIFTSP IKALSNQKYR EMYEEFQDVG LMTGDVTINP TASCLVMTTE ILRSMLYRGS
EVMREVAWVI FDEIHYMRDS ERGVVWEETI ILLPDNVHYV FLSATIPNAR QFAEWICHLH
KQPCHVIYTD YRPTPLQHYI FQEDNFNTAM QVLRDAGDLA KGDQKGRKGG TKGPSNVFKI
VKMIMERNFQ PVIIFSFSKK DCEAYALQMT KLDFNTDEEK KMVEEVFSNA IDCLSDEDKK
LPQVEHVLPL LKRGIGIHHG GLLPILKETI EILFSEGLIK ALFATETFAM GINMPARTVL
FTNARKFDGK DFRWISSGEY IQMSGRAGRR GMDDRGIVIL MVDEKMSPTI GKQLLKGSAD
PLNSAFHLTY NMVLNLLRVE EINPEYMLEK SFYQFQHYRA IPGVVEKVKN SEEQYNKIVI
PNEESVVIYY KIRQQLAKLG KEIEEYIHKP KYCLPFLQPG RLVKVKNEGD DFGWGVVVNF
SKKSNVKPNS GELDPLYVVE VLLRCSKESL KNSATEAAKP AKPDEKGEMQ VVPVLVHLLS
AISSVRLYIP KDLRPVDNRQ SVLKSIQEVQ KRFPDGIPLL DPIDDMGIQD QGLKKVIQKV
EAFEHRMYSH PLHNDPNLET VYTLCEKKAQ IAIDIKSAKR ELKKARTVLQ MDELKCRKRV
LRRLGFATSS DVIEMKGRVA CEISSADELL LTEMMFNGLF NDLSAEQATA LLSCFVFQEN
SSEMPKLTEQ LAGPLRQMQE CAKRIAKVSA EAKLEIDEET YLSSFKPHLM DVVYTWATGA
TFAHICKMTD VFEGSIIRCM RRLEELLRQM CQAAKAIGNT ELENKFAEGQ YQMHKLTREY
SEQKDTPAFM EFTF
//