ID A0A2K6LF99_RHIBE Unreviewed; 1024 AA.
AC A0A2K6LF99;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Integrin subunit alpha 10 {ECO:0000313|Ensembl:ENSRBIP00000022172.1};
GN Name=ITGA10 {ECO:0000313|Ensembl:ENSRBIP00000022172.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000022172.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000022172.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000022172.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A2K6LF99; -.
DR Ensembl; ENSRBIT00000046061.1; ENSRBIP00000022172.1; ENSRBIG00000035019.1.
DR GeneTree; ENSGT00940000158423; -.
DR OMA; SRNITRY; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF26; INTEGRIN ALPHA-10; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 4.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 19..1024
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5014209075"
FT TRANSMEM 976..1002
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT DOMAIN 24..207
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 329..391
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 392..450
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 454..514
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1024 AA; 112617 MW; 63A682666C82517D CRC64;
MELLLITHLF LPLVFLTGCP TYMDVVIVLD GSNSIYPWSE VQTFLRRLVG KLFIDPEQIQ
VGLVQYGESP VHEWSLGDFR TKEEVVRAAK NLSRREGRET KTAQAIMVAC TEGFSQSHGG
RPEAARLLVV VTDGESHDGE KLPAALKTCE AGRVTRYGIA VLGHYLRRQR DPSSFLREIR
TIASDPDERF FFNVTDEAAL TDIVDALGDR IFGLEGTHAE NESSFGLEMS QIGFSTHRLK
DGILFGMVGA YDWGGSVLWL EGGHHLFPPR MALEDEFPSA LQNHAAYLGY SVSSMLLPGG
RRLFLSGAPR FRHRGKVIAF QLKKDGAVRV AQSLQGEQIG SYFGSELCPL DTDRDGTTDV
LLVAAPMFLG PQNKETGRVY VYLVGQQSLL TLQGTLQPEP PQDARFGFAM SALPDLNQDG
FADVAVGAPL EDGHQGALYL YHGTQSGVRP HPAQRIAAAS MSHALSYFGR SVDGRLDLDG
DDLVDVAVGA QGAAILLSSR PIVHLAPSLE VTPQAISVVQ RDCRRRGQEA VCLTAALCFQ
VTSRTPGRWD RRFYMKFTAS LDEWTAGARA AFDGSGQRLS PRRLRLSVGN VTCEQLHFHV
LDTSDYLRPV AFAVTFALDN TTKPGPVLDE GSPTSIQKLV PFSKDCGPDN ECVTDLVLQV
NMDIRGSRKA PFVVRGGRRK ALVSATLENR KENAYNTSLS LIFSRNLHLA SLTPQRDSPI
KVECAAPSTH ARLCIVGHPV FQTRAKVTFL LEFEFSCSSL LSQVFVKLTA SSDSLERDGT
LRDNTAQTSA HIQYEPHLLF SSESTLHRYE VHPYGTLPVG PGPEFKTTLR VQNLGCYVVS
GLIISALLPA VAHGGNYFLS LSQVITNNAS CTVQNLTEPP ASPVHPEELQ HTNRLNGSNT
QCQVVRCHLG QLAKGTEVSV GLLRLVHNEF FRRAKFKSLM VVSTFELGTE EGSVLQLTEA
SRWSESLLEV VQTRPILISL WILIGSVLGG LLLLALLVFC LWKLGFFAHK KIPEEEKREE
KLEQ
//
