ID A0A2K6LI56_RHIBE Unreviewed; 1308 AA.
AC A0A2K6LI56;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRD {ECO:0000313|Ensembl:ENSRBIP00000023208.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000023208.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000023208.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000023208.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR Ensembl; ENSRBIT00000047101.1; ENSRBIP00000023208.1; ENSRBIG00000035517.1.
DR GeneTree; ENSGT00940000153617; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 3.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 785..808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 68..157
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 165..247
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 254..344
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 349..445
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 447..536
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 889..1299
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1217..1290
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 816..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1308 AA; 147409 MW; 9DC8C34AC0D75148 CRC64;
MFERIWKRFT KKVTLAAWLP RGIEYPADMI CLGSGENFNV GGRKISYERV RFRRPHLPLE
DQIPRGFPTI DMGPQLKVVE RTRTATMLCA ASGNPDPEIT WFKDFLPVDT SNNNGRIKQL
RSGALQIEQS EESDQGKYEC VATNSAGTRY SAPANLYVRV RRVPPRFSIP PTNHEIMPGG
SVNITCVAVG SPMPYVKWML GAEDLTPEDD MPIGRNVLEL NDVRQSANYT CVAMSTLGVI
EAIAQITVKA LPKPPGTPVV TESTATSITL TWDSGNPEPV SYYIIQHKPK NSEEPYKEID
GVATTRYSVA GLSPYSDYEF RVVAVNNIGR GPPSEPVLTQ TSEQAPSSAP RDVQARMLSS
TTILVQWKEP EEPNGQIQGY RVYYTMDPTQ HVNNWMKHNV ADSQITTIGN LVPQKTYSVK
VLAFTSIGDG PLSGDIQVIT QTGVPGQPLN FKAEPESETS ILLSWTPPRS DTIANYELVY
KDGEHGEEQR ITIEPGTSYR LQGLKPNSLY YFRLAARSPQ GLGASTAEIS ARTMQSMFAK
NFHVKAVMKT SVLLSWEIPE NYNSAMPFKI LYDDGKMVEE VDGRATQKLI VNLKPEKSYS
FVLTNRGNSA GGLQHRVTAK TAPDVLRTKP AFIGKTNLDG MITVQLPEVP ANENIKGYYI
IIVPLKKSRG KFIKPWESPD EMELDELLKE ISRKRRSIRY GREVELKPYI AAHFDVLPTE
FTLGDDKHYG GFTNKQLQSG QEYVFFVLAV MEHAESKMYA TSPYSDPVVS MDLDPQPITD
EEEGLIWVVG PVLAVVFIIC IVIAILLYKR KRAESDSRKS SIPNSKEIPS HHPTDPVELR
RLNFQTPGSD DSGYPGNLHS SSMASHPPIP ILELADHIER LKANDNLKFS QEYESIDPGQ
QFTWEHSNLE VNKPKNRYAN VIAYDHSRVL LSAIEGIPGS DYVNANYIDG YRKQNAYIAT
QGSLPETFGD FWRMIWEQRS ATVVMMTKLE ERSRVKCDQY WPSRGTETHG LVQVTLLDTV
ELATYCVRTF ALYKNGSSEK REVRQFQFTA WPDHGVPEHP TPFLAFLRRV KTCNPPDAGP
MVVHCSSKAH TSRFISANLP CNQFKNRLVN IMPYESTRVC LQPIRVVGGS DYINACFVDA
LIFTCALEKC HQYWPAERSA RYQYFVVDPM AEYNMPQYIL RKFKVTDARD GQSRTVRRFQ
FTHWPEQGVA KSGEGFIDFI GQVHKTKQQF GQDGPISVHC SMGVGRTGVF ITLSIVLERM
RYEGVVDIFQ TVKMLRTQRP AMVQTEDQYQ FCYRAALEYL GSFDHYAT
//
