ID A0A2K6LKS2_RHIBE Unreviewed; 1883 AA.
AC A0A2K6LKS2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=CDK5 regulatory subunit-associated protein 2 {ECO:0000256|ARBA:ARBA00020479};
GN Name=CDK5RAP2 {ECO:0000313|Ensembl:ENSRBIP00000024145.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000024145.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000024145.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000024145.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Golgi
CC apparatus {ECO:0000256|ARBA:ARBA00004555}.
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DR STRING; 61621.ENSRBIP00000024145; -.
DR Ensembl; ENSRBIT00000048046.1; ENSRBIP00000024145.1; ENSRBIG00000035950.1.
DR GeneTree; ENSGT00950000183190; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000931; C:gamma-tubulin ring complex; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0035371; C:microtubule plus-end; IEA:Ensembl.
DR GO; GO:0000242; C:pericentriolar material; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:Ensembl.
DR GO; GO:0007099; P:centriole replication; IEA:Ensembl.
DR GO; GO:0007059; P:chromosome segregation; IEA:Ensembl.
DR GO; GO:0001578; P:microtubule bundle formation; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0031116; P:positive regulation of microtubule polymerization; IEA:Ensembl.
DR GO; GO:0090266; P:regulation of mitotic cell cycle spindle assembly checkpoint; IEA:Ensembl.
DR InterPro; IPR042791; CDK5RAP2.
DR InterPro; IPR012943; Cnn_1N.
DR PANTHER; PTHR46930; CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 2; 1.
DR PANTHER; PTHR46930:SF1; CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF07989; Cnn_1N; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 60..132
FT /note="Centrosomin N-terminal motif 1"
FT /evidence="ECO:0000259|Pfam:PF07989"
FT REGION 1005..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1485..1509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1637..1696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1744..1764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 60..162
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 216..243
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 267..456
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 566..610
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1179..1223
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1385..1419
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1013..1035
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1640..1654
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1656..1696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1883 AA; 213877 MW; 80E99864334DCD85 CRC64;
MMDSVLEEDV TLPGTLSGCS GLVPNVPDDL DGINPDARLG NGVLPNVSEE TVSPTRARNM
KDFENQITEL KKENFNLKLR IYFLEERMQQ EFHGPTEHIY KTNIELKVEV ESLKRELQER
ERLLVKASKA VESLAEAGGS EIQRVKEDAR KKVQQVEDLL TKRILLLEKD VKAAQAELEK
AFAGTETEKA LRLSLESKLS EMKKMHKGDL AMALVLDEKD RLIEELKLSL KSKEALIQCL
KEEKSQMASP DENVSSGELR GLCAVPREEK ERETEAAQME HQKERNSFEE RIQALEKDLR
EKEREIATEK KNSLKRDKAI QGLTMALKSK EKKVEELNSE IEKLSAAFAK ARETLQKAQT
QEFQGSEDYE AALSGKEALL AELRSQNLTK SAENHRLRRS IKKITQELSD LQQERERLEK
DLEEAHREKS RGDCTIRVMN EREKAMENRY KNLLSESSKK LHNQEQVIKH LTESTNHKDM
LLQKFNEKDL EVIQQNRYLM TAEDLELRSE GLITEKCSSQ QSPGSKTIFS KEEKQSSDCQ
ELIQVLKKER DIYTHLVKSL QESDSINNLQ AELNNIFALR KQLERDVLSY QNLQKTLEEQ
ISEIRRREEE SFSFYSDQTS YLSICLEENN RFQVEHFLKK NLRKGIDLLT FSLVKELHTD
NQHLKKTIFD LSCMGFQGNG IPDRLVSTEQ TELMASKEDE DTIKIGEDDE NNFLSDQHLQ
QSNEIMKDLS KGGCKNGYLR RTEPKILESD GAQAPGCLEE GVFINLLAPL FNEKATLLLE
SRPDLLKVVR ELLLGHLCLT EQEVSGEHLG GKTEKTPKQK GELVHFVQTN SFSKPHDELK
LSCEAQLVKA GEVPKVELKD ASVQTVAMEG DLHRSKHEAV GEAWEEKPIN TALRAEHRPE
NLHRVPGWQA ALLSLPGGTN REAKKSRLPI LIKPSQSLRN TYRLPATQEV VTQLQSQILE
LQGELKEFKT CNKQLHQKLI LAEAMMEGRP TPDKMLLNAQ PPVGAAYQDN PGEQKGIKTT
SSAWSDKEMD SDQQTSYEIG SEICPPDDLA SLPSCKENPE DVLSPTSVAT YLSSKSQPSA
KVSVMGTDQS ESIDTSNETE CLKQKIHDLE TELEGYQNFI FQLQKHSQCS EAIITVLCGT
EGAQDGLSKP KSSSDEEEMT FSGLHQVQYV KHMKILHPLA AEMIDSRMLE NLKQQLEEQE
YELQKEQNLN IELFSEIHNL QNKFRDLSPS RYNSLVQSQA RELSLQRQQI KDGHGICVIS
RQHMNTMIKA FEELLQASDV DYCVAEGFRE QLNQCAELLE KLEKLFLNGK SVGVEMNTQN
ELMERIEEDN LTYQHLLPES PEPSASHVLS DYETSEKSFF SQDQKQDNET EKTSVMVNNF
SEDLLMEHIQ EIRTLRKRLE ESIKTNDKLR KQLERQGSEF DQGSTNTFAS GSELHSSLTS
EIHFLRKQNQ ALNAVLIKAS RDKQKENDKL RESLSRKTAS LEHLQREYAS VKEENERLQK
EGSEKERHNQ QLIQEVRHSG QELSRVQEEV KLRQQLLSQN DKLLQSLRVE LKAYEKLDEE
HRRLREASGE GWKGQDPFRD LHSLLMEIQA LRLQLERSIE TSSTLQSSLE EQLARGAEKA
QEGALTLAIQ ALSIPEVPLQ PDKHDGDKYP MESDNSFDLF DSSQAVTPKS VSETPPLSGN
DTDSLSCDSG SSATSTPCVS RLVAGHRLWA SKNGRHVLGL IEDYEALLKQ IGQGQRLLAE
MDIQTQEAPS STSQELGAKG PPPAPLSKFV SSVSTAKLTL EEAYGRLKLL WRVSVPEDGQ
CPLHCEQIGE MKAEVTKLHK KLFEQEKKLQ NTMKLLQLSK RQEKVIFDQL VVTHRILRKA
RGNLELRPGG AHPGTCSPSR PGS
//
