ID   A0A2K6LNE8_RHIBE        Unreviewed;       836 AA.
AC   A0A2K6LNE8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Zinc finger CCCH-type containing 12B {ECO:0000313|Ensembl:ENSRBIP00000025004.1};
GN   Name=ZC3H12B {ECO:0000313|Ensembl:ENSRBIP00000025004.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000025004.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000025004.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000025004.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the ZC3H12 family.
CC       {ECO:0000256|ARBA:ARBA00010922}.
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DR   RefSeq; XP_017718164.1; XM_017862675.1.
DR   AlphaFoldDB; A0A2K6LNE8; -.
DR   STRING; 61621.ENSRBIP00000025004; -.
DR   Ensembl; ENSRBIT00000048911.1; ENSRBIP00000025004.1; ENSRBIG00000036402.1.
DR   GeneID; 108522457; -.
DR   KEGG; rbb:108522457; -.
DR   CTD; 340554; -.
DR   GeneTree; ENSGT00940000159316; -.
DR   OMA; LEHMTSM; -.
DR   OrthoDB; 180910at2759; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd18729; PIN_Zc3h12-like; 1.
DR   Gene3D; 3.40.50.11980; -; 1.
DR   InterPro; IPR040546; Rege-1_UBA-like.
DR   InterPro; IPR040757; Regnase_1/ZC3H12_C.
DR   InterPro; IPR021869; RNase_Zc3h12_NYN.
DR   InterPro; IPR000571; Znf_CCCH.
DR   PANTHER; PTHR12876; N4BP1-RELATED; 1.
DR   PANTHER; PTHR12876:SF27; RIBONUCLEASE ZC3H12B-RELATED; 1.
DR   Pfam; PF18561; Regnase_1_C; 1.
DR   Pfam; PF11977; RNase_Zc3h12a; 1.
DR   Pfam; PF18039; UBA_6; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   3: Inferred from homology;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00723}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00723}.
FT   DOMAIN          355..380
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50103"
FT   ZN_FING         355..380
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT   REGION          1..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..61
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   836 AA;  94087 MW;  7577EC806780DB67 CRC64;
     MTATAEVETP KMEKSASKEE KQQPKQDSTE QGNADSEEWM SSESDPEQIS LKSSDNSKSC
     QPRDGQLKKK EMPSKPHRQL CRSPCLDRPS FSQSSILQDG KLDLEKEYQA KMEFALKLGY
     AEEQIQSVLN KLGPESLIND VLAELVRLGN KGDSEGQINL SLLVPRGPSS REIASPELSL
     EDEIDNSDNL RPVVIDGSNV AMSHGNKEEF SCRGIQLAVD WFLDKGHKDI TVFVPAWRKE
     QSRPDAPITD QDILRKLEKE KILVFTPSRR VQGRRVVCYD DRFIVKLAFD SDGIIVSNDN
     YRDLQVEKPE WKKFIEERLL MYSFVNDKFM PPDDPLGRHG PSLENFLRKR PIVPEHKKQP
     CPYGKKCTYG HKCKYYHPER ANQPQRSVAD ELRISAKLST VKTMSEGTLA KCGTGMSSAK
     GEITSEVKRV APKRQSDPSI RSVAVEPEEW LSIARKPEAS SVPSLVTALS VPTIPPPKSH
     AVGALNTRSA SSPVPGSSHF PHQKASLEHM ASMQYPPILV TNSHGTPISY AEQYPKFESM
     GDHGYYSMLG DFSKLNINSM HNREYYMAEV DRGVYARNPN LCPDSRVSHT RNDNYSSYNN
     VYLAVADTHP EGNLKLHRSA SQNRLQPFPH GYHEALTRVQ SYGPEDSKQG PHKQSVPHLA
     LHAQHSATGT RSSCPADYPM PPNIHPGATP QPGRALVMTR MDSISDSRLY ESNPVRQRRP
     PLCREQHASW DPLPCATDSY GYHSYPLSNS LMQPCYEPVM VRSVPEKMEQ LWRNPWVGMC
     NDSREHMIPE HQYQTYKNLC NIFPSNIVLA VMEKNPHTAD AQQLAALIVA KLRAAR
//