ID A0A2K6LRI7_RHIBE Unreviewed; 208 AA.
AC A0A2K6LRI7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=FAS-associated death domain protein {ECO:0000256|PIRNR:PIRNR018586};
DE AltName: Full=FAS-associating death domain-containing protein {ECO:0000256|PIRNR:PIRNR018586};
GN Name=FADD {ECO:0000313|Ensembl:ENSRBIP00000026089.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000026089.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000026089.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000026089.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Apoptotic adaptor molecule that recruits caspase-8 or
CC caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The
CC resulting aggregate called the death-inducing signaling complex (DISC)
CC performs caspase-8 proteolytic activation. Active caspase-8 initiates
CC the subsequent cascade of caspases mediating apoptosis. Involved in
CC interferon-mediated antiviral immune response, playing a role in the
CC positive regulation of interferon signaling.
CC {ECO:0000256|PIRNR:PIRNR018586}.
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DR AlphaFoldDB; A0A2K6LRI7; -.
DR STRING; 61621.ENSRBIP00000026089; -.
DR Ensembl; ENSRBIT00000050003.1; ENSRBIP00000026089.1; ENSRBIG00000036931.1.
DR GeneTree; ENSGT00390000002105; -.
DR OMA; CKMNLVA; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0031265; C:CD95 death-inducing signaling complex; IEA:Ensembl.
DR GO; GO:0097342; C:ripoptosome; IEA:Ensembl.
DR GO; GO:0089720; F:caspase binding; IEA:Ensembl.
DR GO; GO:0035877; F:death effector domain binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:Ensembl.
DR GO; GO:0032813; F:tumor necrosis factor receptor superfamily binding; IEA:Ensembl.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0071550; P:death-inducing signaling complex assembly; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0048535; P:lymph node development; IEA:Ensembl.
DR GO; GO:0097049; P:motor neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0097527; P:necroptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0070236; P:negative regulation of activation-induced cell death of T cells; IEA:Ensembl.
DR GO; GO:0060546; P:negative regulation of necroptotic process; IEA:Ensembl.
DR GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:2000454; P:positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; IEA:Ensembl.
DR GO; GO:1900119; P:positive regulation of execution phase of apoptosis; IEA:Ensembl.
DR GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:0045651; P:positive regulation of macrophage differentiation; IEA:Ensembl.
DR GO; GO:0045862; P:positive regulation of proteolysis; IEA:Ensembl.
DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of type II interferon production; IEA:Ensembl.
DR GO; GO:0048536; P:spleen development; IEA:Ensembl.
DR GO; GO:0033077; P:T cell differentiation in thymus; IEA:Ensembl.
DR GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
DR GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR GO; GO:0036462; P:TRAIL-activated apoptotic signaling pathway; IEA:Ensembl.
DR CDD; cd08306; Death_FADD; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR016729; FADD_DD.
DR InterPro; IPR049634; FADD_vert.
DR PANTHER; PTHR15077:SF9; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; 1.
DR PANTHER; PTHR15077; FAS-ASSOCIATING DEATH DOMAIN-CONTAINING PROTEIN FADD; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF01335; DED; 1.
DR PIRSF; PIRSF018586; FADD; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00031; DED; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50168; DED; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|PIRNR:PIRNR018586};
KW Immunity {ECO:0000256|PIRNR:PIRNR018586};
KW Innate immunity {ECO:0000256|PIRNR:PIRNR018586};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 3..81
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 97..181
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 188..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 208 AA; 23239 MW; FAB7305A4D494077 CRC64;
MDPFLVLLHS VSSSLSSSEL TELKFLCLGR VGKRKLERVQ SGLDLFSVLL EQNDLDPGHT
DLLRELLASL RRHDLLRRLD DFEAGVAAGA APGEEDLCAA FNVVCDNVGK EWRRLARQLK
VSDTKIDSIE DRYPRNLTER VRESLRIWKN TEKEKATVAC LVAALRACQM NLVADLVQEV
QQARDLQNRS GAMSPMSWNS DASTSEAS
//
