ID A0A2K6LRJ5_RHIBE Unreviewed; 1741 AA.
AC A0A2K6LRJ5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Myosin VC {ECO:0000313|Ensembl:ENSRBIP00000026099.1};
GN Name=MYO5C {ECO:0000313|Ensembl:ENSRBIP00000026099.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000026099.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000026099.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000026099.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSRBIT00000050013.1; ENSRBIP00000026099.1; ENSRBIG00000036923.1.
DR GeneTree; ENSGT00940000157971; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd15476; Myo5c_CBD; 1.
DR CDD; cd01380; MYSc_Myo5; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.220.10; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR037991; Myo5c_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR036103; MYSc_Myo5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 5.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 7..61
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 66..752
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1420..1696
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT REGION 631..653
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 883..1097
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1210..1336
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 160..167
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1741 AA; 202538 MW; 03E4D4F48B7D1A59 CRC64;
LAVPELDFYN RVWIPDPEEV WKSAEIATDY RVGDKVLRLL LEDGTELDYS VNPESLPPLR
NPDILVGEND LTALSYLHEP AVLHNLRIRF AESKLIYTYS GIILVAMNPY KQLPIYGDAI
IHAYSGQNMG DMDPHIFAVA EEAYKQMARS NRNQSIIVSG ESGAGKTVSA RYAMRYFATV
SKSGSNAHVE DKVLASNPIT EAVGNAKTTR NDNSSRFGKY TEISFDEQNQ IIGANMRTYL
LEKSRVVFQS ENERNYHIFY QLCASAQQSE FKHLKLGSAE EFNYTRMGGN TVIEGVNDQA
EMVETQKTFT LLGFKEDFQM DVFKILAAIL HLGNVQIIAV GNERSSVSED DSHLKVFCEL
LGLESGRVAQ WLCNRKIVTS SETVVKPMTR PQAVNARDAL AKKIYAHLFD FIVERINQAL
QFSGKQHTFI GVLDIYGFET FDVNSFEQFC INYANEKLQQ QFNMHVFKLE QEEYMKEDIP
WTLIDFYDNQ PVIDLIEAKM GILELLDEEC LLPHGTDENW LQKLYNNFVN KNPLFEKPRM
SNTSFVIQHF ADKVEYKCEG FLEKNRDTVY DMLVEILRAS KFHLCANFFQ ENPASPSPFG
SMITVKSAKE VIKPNSKHFR TTVGSKFRSS LYLLMETLNA TTPHYVRCIK PNDEKLPFEF
DSKRIVQQLR ACGVLETIRI SAQSYPSRWT YIEFYSRYGI LMTKQELSFS DKKEVCKAVL
HRLIQDSNQY QFGKTKIFFR AGQVAYLEKL RLDKLRQSCV VIQKHIRGWL HRKKFLRERR
AALIIQQYFR GQQTVRKAIT AVALKEAWAA IIIQKHCRGY LVRNLYQLIR VATITIQAYT
RGFLARRRYR KMLEEHKAVI LQKYARAWLA RRRFQSIRRF VLNIQLTYRV QRLQKKLEDQ
NKENHGLVEK LTSLAALRAG DVEKIQKLEV ELERAAAHRR NYEEKGKRYR DAVEEKLAKL
QKHNSELETQ KDQIQLKLQE KTEELKEKMD NLTKQLFDDV QKEERQRMLL EKSFELKTQD
YEKQIQSLKE QIKALKDEKT QLQQLVEEEH VTSDGLKAEV ARLSKQAKTI SEFEKEIQLL
QAQKIDVEKH VQSQKREMRE KMSEITKQLL ESYDIEDVRS RLSVEDLEHL NEDGELWFAY
EGLKKATRVL ESHFQSQKEC YEKEIEALNF KVVHLSQEIN HLQKLFREEN DINESIRLEV
TRLTSENMMI PDFKQQISEL EKQKQDLEIR LNEQTEKMKG KLEELSNQLN RSQKEEGTQR
KAMEAQNEIH AKEKEKLIDK IQEMQEASDH LKKQFETESE VKSNFWQEAS RLILENRDLE
EELDMKDRVI KKLQDQVKTL SKTTGKASDV HSSSGPKEYL GMLQYKREDE AKLIQNLILD
LKPRGVVVNM IPGLPAHILF MCVRYADSLN DANMLKSLMN STINGIKQVV KEHLEDFEML
SFWLSNTCHF LNCLKQYSGE EEFMKHNSPH QNKNCLNNFD LSEYRQILSD VAIRIYHQFI
IIMEKNIQPI IVPGMLEYES LQGISGLKPT GFRKRSSSID DTDAYTMTSV LQQLSYFYTT
MCQNGLDPEL VRQAVKQLFF LIGAVTLNSL FLRKDMCSCR KGMQIRCNIS YLEEWLKDKN
LQNSLAKETL EPLSQAAWLL QVKKTTDSDA TEIYERCTSL SAVQIIKILN SYTPIDDFEK
RVTPSFVRKV QALLNSREDS SQLMLDTKYL FQVTFPFTPS PHALEMIQIP SSFKLGFLNR
L
//
