GenomeNet

Database: UniProt
Entry: A0A2K6LU39_RHIBE
LinkDB: A0A2K6LU39_RHIBE
Original site: A0A2K6LU39_RHIBE 
ID   A0A2K6LU39_RHIBE        Unreviewed;      1043 AA.
AC   A0A2K6LU39;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=F-actin monooxygenase {ECO:0000256|ARBA:ARBA00012709};
DE            EC=1.14.13.225 {ECO:0000256|ARBA:ARBA00012709};
GN   Name=MICAL1 {ECO:0000313|Ensembl:ENSRBIP00000027024.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000027024.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000027024.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000027024.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-
CC         (R)-S-oxide-[F-actin] + NADP(+); Xref=Rhea:RHEA:51308, Rhea:RHEA-
CC         COMP:12953, Rhea:RHEA-COMP:12956, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16044,
CC         ChEBI:CHEBI:45764, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC         EC=1.14.13.225; Evidence={ECO:0000256|ARBA:ARBA00001591};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the Mical family.
CC       {ECO:0000256|ARBA:ARBA00008223}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K6LU39; -.
DR   Ensembl; ENSRBIT00000050950.1; ENSRBIP00000027024.1; ENSRBIG00000037357.1.
DR   GeneTree; ENSGT00940000159117; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030042; P:actin filament depolymerization; IEA:UniProt.
DR   CDD; cd21196; CH_MICAL1; 1.
DR   CDD; cd09358; LIM_Mical_like; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR022735; bMERB_dom.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR002938; FAD-bd.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR23167:SF35; [F-ACTIN]-MONOOXYGENASE MICAL1; 1.
DR   PANTHER; PTHR23167; CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED; 1.
DR   Pfam; PF12130; bMERB_dom; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF01494; FAD_binding_3; 1.
DR   Pfam; PF00412; LIM; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM01203; DUF3585; 1.
DR   SMART; SM00132; LIM; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR   PROSITE; PS51848; BMERB; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW   ProRule:PRU00125};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00125}; Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023033};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00125}.
FT   DOMAIN          521..625
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          672..734
FT                   /note="LIM zinc-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50023"
FT   DOMAIN          894..1043
FT                   /note="BMERB"
FT                   /evidence="ECO:0000259|PROSITE:PS51848"
FT   REGION          724..815
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          840..862
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          904..931
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        753..772
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        848..862
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1043 AA;  115359 MW;  C52E3CF3FF472A13 CRC64;
     FHLSSHLPLE ASMASPTSTN PAHAHFESFL QAQLCQDVLS SFQELCGALG LEPGGGLPQY
     HKIKDQLNYW SAKSLWTKLD KRAGQPVYQQ GRACTSTKCL VVGAGPCGLR VAVELALLGA
     RVVLVEKRTK FSRHNVLHLW PFTIHDLRAL GAKKFYGRFC TGTLDHISIR QLQLLLLKVV
     LLLGVEIHWG VTFTGLQPPP RKGSGWRAQL QPNPPAQLAN YEFDVLISAA GGKFVPEGFK
     VREMRGKLAI GITANFVNGR TVEETQVPEI SGVARIYNQS FFQSLLKATG IDLENIVYYK
     DDTHYFVMTA KKQCLLRLGV LRQDWPDTDR LLGSANVVPE ALQRFARAAA DFATHGKLGK
     LEFAQDAHRQ PDVSAFDFTS MMRAESSARV QEKHGARLLL GLVGDCLVEP FWPLGTGVAR
     GFLAAFDAAW MVKRWAEGAE PLEVLAERES LYQLLSQTSP ENMHRNVAQY GLDPATRYPN
     LNLRAVTPNQ VRDLYDVLTK EPVQRNNDKR DAGMLTTGGS AGTQEELLRW CQEQTAGYPG
     VHVSDLSSSW TDGLALCALV HRLQPGVLEP SELQGLGALE ATAWALKVAE HELGITPVVS
     AQAVVAGSDP LGLIAYLSHF HSAFKSTAHS PGPVSQASPG TSSAVLFLGK LQRTLQRSRA
     KVKSLGRAGA GDLCALCGEH LYVLERLCVD GHFFHRSCFR CHTCEATLWP GGYEQHPGDG
     HFYCLQHLPQ PDHQEEGSDG GPESPELPTP SENSMPPGLS TPTASQEGAG PVPDPSQPTR
     RRIHLSSLER QRLSSLNLTP DPEMEPPPKP PRSCSALARH ALESSFVGWG LPVQSPQALV
     AMEKEEEESS SSSEEEEDVP LDSDVEQALQ TFAKTSGTMK DYPTWRQTLL RRAKEEEMKR
     FRKAQTIQRR LNEIEGALRE LEAEGVKLEL ALRRQSSSPE QQKKLWVGQL LQLVDKKNSL
     VAEEAELMIT VQELNLEEKQ WQLDQELRGY MNREETLKTA ADRQAEDQVL RKLVDLVNQR
     DALIRFQEER RLSELALGTG AQG
//
DBGET integrated database retrieval system