ID A0A2K6LWL2_RHIBE Unreviewed; 1173 AA.
AC A0A2K6LWL2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=PR/SET domain 16 {ECO:0000313|Ensembl:ENSRBIP00000027921.1};
GN Name=PRDM16 {ECO:0000313|Ensembl:ENSRBIP00000027921.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000027921.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000027921.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000027921.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6LWL2; -.
DR STRING; 61621.ENSRBIP00000027921; -.
DR Ensembl; ENSRBIT00000051857.1; ENSRBIP00000027921.1; ENSRBIG00000037838.1.
DR GeneTree; ENSGT00940000160951; -.
DR OMA; PRGAYED; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0016235; C:aggresome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:Ensembl.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24406:SF19; PR DOMAIN ZINC FINGER PROTEIN 16 ISOFORM X1; 1.
DR PANTHER; PTHR24406; TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 1..108
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 127..154
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 178..205
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 206..233
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 234..262
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 263..290
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 291..318
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 320..347
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 848..875
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 876..904
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 905..932
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 430..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 981..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..957
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1032
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1173 AA; 129474 MW; 1D504C4A539E8B80 CRC64;
MEAGERLGPC VVVPRAAAKE TDFGWEQILT DTEVPPQEGC IQKISEDLGS EKFCVDANQA
GAGSWLKYIR VACSCDDQNL TMCQISEQIY YKVIKDIEPG EELLVHVKEG IYPLGTVPPC
LDEEPTFRCD ECDELFQSKL DLRRHKKYTC GSVGAALYEG LAEELKPEGL GGGSGQAHEC
KDCERMFPNK YSLEQHMVIH TEEREYKCDQ CPKAFNWKSN LIRHQMSHDS GKRFECENCV
KVFTDPSNLQ RHIRSQHVGA RAHACPDCGK TFATSSGLKQ HKHIHSTVKP FICEVCHKSY
TQFSNLCRHK RMHADCRTQI KCKDCGQMFS TTSSLNKHRR FCEGKNHYTP GGIFAPGLPL
TPSPMMDKTK PSPSLNHASL GFNEYFPSRP HPGSLPFSTA PPAFPALTPG FPGIFPPSLY
PRPPLLPPTP LLKSPLNHTQ DAKLPSPLGN PALPLVSAVS NSSQGTTAAA GPEEKFESRL
EDSCVEKMKT RSSDMSDGSD FEDVNTTTGT DLDTTTGTGS DLDSDVDSDP DKDKGKGKSA
EGQPEFGGGL APPGAPNSVA EVPVFYSQHS FFPPPDEQLL TATGAAGDSI KAIASIAEKY
FGPGFMGMQE KKLGSLPYHS AFPFQFLPNF PHSLYPFTDR ALAHNLLVKA EPKSPRDALK
VGGPSAECPF DLTTKPKDVK PILPMPKGPS APASSEEQPL DLSIGSRARA SQNGGGREPR
KNHVYGERKL GVSEGLPQVC PARLPQQPPL HYAKPSPFFM DPIYSRVEKR KVTDPVGALK
EKYLRPSPLL FHPQMSAIET MTEKLESFAA MKADSGSSLQ PLPHHHFNFR SPPSTLSDPI
LRKGKERYTC RYCGKIFPRS ANLTRHLRTH TGEQPYRCKY CDRSFSISSN LQRHVRNIHN
KEKPFKCHLC NRCFGQQTNL DRHLKKHEHE NAPVSQHPGV LTNHLGTSAS SPTSESDNHA
LLDEKEDSYF SEIRNFIANS EMNQASTRTE KRPEMQDVDG SSQCPGLASE KQEDVEEEDD
DDLEEDDEDS LAGKSQDDTV SPAPEPQATY EDEEDEEPPA SLAVGFDHTR RCAEDHEGGL
LALEPMPTFG KGLDLRRAAE EAFEVKDVLN STLDSETLKH TLCRQAKNQA YAMMLSLSED
TPLHTPSQGS LDAWLNITGT TSESGAFHPI NHL
//
