ID   A0A2K6LX19_RHIBE        Unreviewed;       856 AA.
AC   A0A2K6LX19;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Paladin {ECO:0000256|ARBA:ARBA00040012};
GN   Name=PALD1 {ECO:0000313|Ensembl:ENSRBIP00000028076.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000028076.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000028076.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000028076.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   -!- SIMILARITY: Belongs to the paladin family.
CC       {ECO:0000256|ARBA:ARBA00037958}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_017728620.1; XM_017873131.1.
DR   RefSeq; XP_017728621.1; XM_017873132.1.
DR   RefSeq; XP_017728622.1; XM_017873133.1.
DR   RefSeq; XP_017728623.1; XM_017873134.1.
DR   RefSeq; XP_017728625.1; XM_017873136.1.
DR   RefSeq; XP_017728626.1; XM_017873137.1.
DR   STRING; 61621.ENSRBIP00000028064; -.
DR   Ensembl; ENSRBIT00000051998.1; ENSRBIP00000028062.1; ENSRBIG00000037915.1.
DR   Ensembl; ENSRBIT00000052000.1; ENSRBIP00000028064.1; ENSRBIG00000037915.1.
DR   Ensembl; ENSRBIT00000052012.1; ENSRBIP00000028076.1; ENSRBIG00000037915.1.
DR   Ensembl; ENSRBIT00000052016.1; ENSRBIP00000028080.1; ENSRBIG00000037915.1.
DR   GeneID; 108530338; -.
DR   KEGG; rbb:108530338; -.
DR   CTD; 27143; -.
DR   GeneTree; ENSGT00390000005448; -.
DR   OrthoDB; 49159at2759; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   CDD; cd17659; PTP_paladin_1; 1.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   PANTHER; PTHR23339:SF96; PALADIN; 1.
DR   PANTHER; PTHR23339; TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR   Pfam; PF14566; PTPlike_phytase; 2.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SMART; SM01301; PTPlike_phytase; 2.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT   DOMAIN          262..384
FT                   /note="Protein-tyrosine phosphatase catalytic"
FT                   /evidence="ECO:0000259|SMART:SM00404"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   856 AA;  96538 MW;  2761C03EBB5A9D20 CRC64;
     MGTTASTAQQ TVSAGTPFEG LQGGGTMDGR HSVSVHSFQT TSLHNSKAKS IIPNKVAPVV
     ITYNCKEEFQ IHDELLKAHY TLGRLSDATP EHYLVQGRYF LVRDVTEKMD ILGTVGSCGA
     PNFRQVQGGL AVFGMGQPSL SGFRRVLQKL QKDGHRECVI FCVREEPVLF LRADEDFVSY
     TPRDKQNLHE NLQGLGPGIR VESLELAIRK EIHDFAQLSE NTYHVYHNIE DLRGEPHAVA
     ILGEDDVHVT EEVYKRPLFL QPTYRYHRLP LPEQGSPLEA QLDAFVSVLR ETPSLLQLCD
     AHGPPPALVF SCQMGVGRTN LGMVLGTLIL LHHSGITSQP EAAPTQAKPL PMEQFQLIQS
     FLRMVSQGRR MVEEVDRAIT ACAELHDLKE VVLENKKKLE GIRPESPAQG SGSRHSIWQR
     ALWSLERYFY LILFNYYLHE QYPLAFALSF SRWLCAHPEL YRLPVTLSSA GPVALRDLIA
     EGSLREDDLV SPDALSTVRE MDVANFRRVP RMPIYGTAQP SAKALASILA YLTDAKRRLQ
     KVVWVSLREE AVLECDGHTH SLRRPGSPVT PDQLETLEAQ LKAHLSEPSP GKEGPPTHRF
     QTWLTTQEVF SQHRRTCPGL TYHRIPMPDF CAPREEDFDQ LLETLRAALS KDPRTGFVFS
     CLSGQGRTTT AMVVAVLAFW HIQGFPEVGE EELVSVPDAK FTKGEFQVVM KVVQLLPDGH
     RVKKEVDAAL DTVSETMTPM HYHLREIIIC TYRQAKAAKE AQETRRLQLR SLQYLERYVC
     LIVFNAYLHL EKAGSWQRSF STWMQEVASK AGIYEILNEL GFPELESGED QPFSRLRYRW
     QEQSCSLEPS APEDLL
//