ID   A0A2K6LZK5_RHIBE        Unreviewed;       560 AA.
AC   A0A2K6LZK5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819, ECO:0000256|PIRNR:PIRNR017222};
DE            Short=eIF-2A {ECO:0000256|PIRNR:PIRNR017222};
GN   Name=EIF2A {ECO:0000313|Ensembl:ENSRBIP00000028950.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000028950.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000028950.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000028950.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC       number of specific mRNAs. Acts by directing the binding of methionyl-
CC       tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC       binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC       whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC       GTP-dependent manner. {ECO:0000256|ARBA:ARBA00003993,
CC       ECO:0000256|PIRNR:PIRNR017222}.
CC   -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC       {ECO:0000256|ARBA:ARBA00009573, ECO:0000256|PIRNR:PIRNR017222}.
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DR   AlphaFoldDB; A0A2K6LZK5; -.
DR   Ensembl; ENSRBIT00000052897.1; ENSRBIP00000028950.1; ENSRBIG00000038363.1.
DR   GeneTree; ENSGT00730000111053; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR011387; TIF2A.
DR   InterPro; IPR013979; TIF_beta_prop-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR   PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR   Pfam; PF08662; eIF2A; 1.
DR   PIRSF; PIRSF017222; eIF2A; 1.
DR   SUPFAM; SSF50960; TolB, C-terminal domain; 1.
PE   3: Inferred from homology;
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW   ECO:0000256|PIRNR:PIRNR017222};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|PIRNR:PIRNR017222};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   Translation regulation {ECO:0000256|ARBA:ARBA00022845,
KW   ECO:0000256|PIRNR:PIRNR017222}; WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT   DOMAIN          191..386
FT                   /note="Translation initiation factor beta propellor-like"
FT                   /evidence="ECO:0000259|Pfam:PF08662"
FT   REGION          409..509
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        443..457
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..504
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   560 AA;  62233 MW;  7E39F267AA363BC6 CRC64;
     MAPSTPLLTV RGSEGLYMVN GPPHFTESTV FPRVNIISVT NKGLLHSFDL PKAVCLEFSP
     KNTVLATWQP YTTSKDGTAG IPNLQLYDVK TGTCLKSFIQ KKTQNWCPSW SEDETLCARS
     VNNEVHFFEN NNFNTIANKL HLQKINDFVL SPGPQPYKVA VYVPGSKGAP SFVRLYQYPN
     FAGPHAALAN KSFFKADKVT MLWNKKATAV LVIASTDVDK TGASYYGEQT LHYIATNGES
     AVVQLPKNGP IYDVVWNSSS TEFCAVYGFM PAKATIFNLK CDPVFDFGTG PRNAAYYSPH
     GHILVLAGFG NLRGQMEVWD VKNYKLISKP VASDSTYFAW CPDGEHILTA TCAPRLRVNN
     GYRIWHYTGS ILHKYDVPSN AELWQVSWQP FLDGIFPAKT ITYQAVPSEV PNEEPKVATA
     YRPPALRNKP ITNSKLHEEE PPQNMKSQSG NDKPLSKTAL KNQRKHEAKK AAKQEARSDK
     SPDLAPTPGP QSTPRNTISQ SISGDPEIDK KIKNLKKKLK AIEQLKEQAA TGKQLEKNQL
     EKIQKETALL QELKDLELGI
//