ID A0A2K6M1L9_RHIBE Unreviewed; 781 AA.
AC A0A2K6M1L9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Myotubularin related protein 10 {ECO:0000313|Ensembl:ENSRBIP00000029678.1};
GN Name=MTMR10 {ECO:0000313|Ensembl:ENSRBIP00000029678.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000029678.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000029678.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000029678.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR AlphaFoldDB; A0A2K6M1L9; -.
DR STRING; 61621.ENSRBIP00000029678; -.
DR Ensembl; ENSRBIT00000053631.1; ENSRBIP00000029678.1; ENSRBIG00000038711.1.
DR GeneTree; ENSGT00940000156900; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR CDD; cd13346; PH-GRAM_MTMR10; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR036004; MTMR10_PH-GRAM.
DR InterPro; IPR022587; MTMR12-like_C.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF39; MYOTUBULARIN-RELATED PROTEIN 10; 1.
DR Pfam; PF12578; 3-PAP; 1.
DR Pfam; PF06602; Myotub-related; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 219..665
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 336..337
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
SQ SEQUENCE 781 AA; 88994 MW; 0B685A32C23975B7 CRC64;
MFSLKPPRPT FRSYLLPPPQ TDDKLNSEPK IKKLEPVLLP GEIVVNEVNF VRKCIATDTS
QYDLWGKLIC SNFKISFITD DPMPLQKFHY RNLLLGEHDV PLTCIEQIVT VNDHKRKQKV
LGPNQKLKFN PTELIIYCKD FRIVRFRFDE SGPESAKKVC LAIAHYSQPT DLQLLFAFEY
VGKKYHNSAN KINGIPSGDG GGGGGNGAGG GSSQKTPLFE TYSDWDREIK RTGASGWRVC
SINEGYMIST CLPEYFVVPS SLADQDLKIF SHSFVGRRMP LWCWSHSNGS ALVRMALIKD
ALLQRKIDQR ICNAITKSHP QRSDVYKSDL DKTLPNIQEV QAAFVKLKQL CVNEPFEETE
EKWLSSLENT RWLEYVRILN YLVYLSFPFS LIIFLCCNHV LSILLTEEEG RDLSCCVASL
VQVMLDPYFR TIIGFQSLIQ KEWVMAGYQF LDRCNHLKRS EKESPLFLLF LDATWQLLEQ
YPAAFEFSET YLAVLYDSTR ISLFGTFLFN SPHQRVKQST EFAISKNIQL GDEKGLKFPS
VWDWSLQFTA KDRTLFHNPF YIGKSPPCVH NGSVKSFKRT KKNYSSTLRG MPSALKNGII
SDQELLPRRN SLILKPKPDP PQQTKSQNSD MEPYFREWFS KPVNLHGVIL PRVSGTHIKL
WKLCYFRWVP EAQISLGGSI TAFHKLSLLA DEVDVLGRML RQQRSGPLEA CYGELGQSRM
YFRASGPHDT DTSGTPEFLS SSFPFSPVGN LCRRSILGTP LSKFLSGAKI WLSTETLANE
D
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