ID A0A2K6M1W9_RHIBE Unreviewed; 403 AA.
AC A0A2K6M1W9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Protein maelstrom homolog {ECO:0000256|ARBA:ARBA00021076};
GN Name=MAEL {ECO:0000313|Ensembl:ENSRBIP00000029764.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000029764.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000029764.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000029764.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Plays a central role during spermatogenesis by repressing
CC transposable elements and preventing their mobilization, which is
CC essential for the germline integrity. Acts via the piRNA metabolic
CC process, which mediates the repression of transposable elements during
CC meiosis by forming complexes composed of piRNAs and Piwi proteins and
CC governs the methylation and subsequent repression of transposons. Its
CC association with piP-bodies suggests a participation in the secondary
CC piRNAs metabolic process. Required for the localization of germ-cell
CC factors to the meiotic nuage. {ECO:0000256|ARBA:ARBA00025698}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the maelstrom family.
CC {ECO:0000256|ARBA:ARBA00007057}.
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DR AlphaFoldDB; A0A2K6M1W9; -.
DR Ensembl; ENSRBIT00000053718.1; ENSRBIP00000029764.1; ENSRBIG00000038763.1.
DR GeneTree; ENSGT00390000003645; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0060964; P:regulation of miRNA-mediated gene silencing; IEA:InterPro.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR024970; Maelstrom.
DR InterPro; IPR039259; Protein_maelstrom.
DR PANTHER; PTHR21358; PROTEIN MAELSTROM HOMOLOG; 1.
DR PANTHER; PTHR21358:SF4; PROTEIN MAELSTROM HOMOLOG; 1.
DR Pfam; PF09011; HMG_box_2; 1.
DR Pfam; PF13017; Maelstrom; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158}.
FT DOMAIN 2..44
FT /note="HMG box"
FT /evidence="ECO:0000259|Pfam:PF09011"
FT DOMAIN 99..295
FT /note="Maelstrom"
FT /evidence="ECO:0000259|Pfam:PF13017"
FT REGION 326..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 45491 MW; 82256001354B279D CRC64;
MPNRKASRNA YYFFVQEKIP ELRRRGLPVA RVADAIPYCS ADWAKPVFTP LRRPGMLVPK
QNVSPPDMST LSLKGDQALL GGIFYFLNIF SHGELPPHCE QRFLPCEIGC VKYSLQEGIM
ADFHSFINPG EIPRGFRFHC QAASDSSHKI PISNFERGHN QATVLQNLYR FIHPNPGNWP
PIYCKSDDRT RVNWCLKHMA KASEIRQDLQ LLTVEDLVVG IYQQKFLKEP SKTWIRSLLD
VAMWDYSSNT RCKWHEENDT LFCALAVCKK IAYCISNSLA TLFGIQLTEA HVPLQDYEAS
NSVTPKMVVL DAGRYQKLRV GSSGFSHFNS ANQEQRSNTP IGDYPSRAKI SGQNSSVRGR
GITRLLESIS NSSSNIHKFS NCDTSLSSYM SQKDGYKSSS SLS
//
