ID A0A2K6M2T0_RHIBE Unreviewed; 2535 AA.
AC A0A2K6M2T0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=[histone H3]-lysine(36) N-trimethyltransferase {ECO:0000256|ARBA:ARBA00012178};
DE EC=2.1.1.359 {ECO:0000256|ARBA:ARBA00012178};
DE AltName: Full=SET domain-containing protein 2 {ECO:0000256|ARBA:ARBA00030091};
GN Name=SETD2 {ECO:0000313|Ensembl:ENSRBIP00000030079.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000030079.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000030079.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000030079.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60324, Rhea:RHEA-COMP:9785, Rhea:RHEA-
CC COMP:15536, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.359;
CC Evidence={ECO:0000256|ARBA:ARBA00000317};
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR Ensembl; ENSRBIT00000054037.1; ENSRBIP00000030079.1; ENSRBIG00000038909.1.
DR GeneTree; ENSGT00940000160086; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0140955; F:histone H3K36 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19172; SET_SETD2; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 1.10.1740.100; Set2, Rpb1 interacting domain; 1.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044437; SETD2/Set2_SET.
DR InterPro; IPR042294; SETD2_animal.
DR InterPro; IPR013257; SRI.
DR InterPro; IPR038190; SRI_sf.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR46711; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR PANTHER; PTHR46711:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF08236; SRI; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1465..1519
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 1521..1638
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1645..1661
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 2360..2393
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1006..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1102..1204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1234..1253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1266..1323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1365..1396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1802..1843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1908..2118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2410..2436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..183
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..383
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..443
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..964
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1066..1083
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1111..1125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1135..1150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1182..1204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1802..1838
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1923..1942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1982..2017
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2026..2051
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2061..2101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2102..2118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2420..2436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2535 AA; 284657 MW; A67AFAAAE8A0E85D CRC64;
MKQLQPQPPP KMGDFYDPEH PTPDRFLPKG TKTKVNLEEQ GRQKVSFSFS LTKKTLQNRF
LTVLGNEKQS DTPNPPAVPL QVDSTPKMKM EIGDTLSTAE ESSPPKSRVE LGKIHFKKHL
LHVTSRPLLA TTTAVASPPT HAAPLPAVIA ESTTVDSPPS SPPPPPPPAQ ATTPSSPAPV
TEPVVLPHTP ITVLMAAPVP LPVDVAVRSL KEPPIIIVPE SLEADTKQDT VSNSSEEHIT
QILNEQADIS SKKEDSHIGK DEEIPDSSKI SLSCKKTGSK KKSSQSEGTF LGSESDEDSV
RTSSSQRSHD LKFSASIEKE RDFKKSSAPL KSEDLGKSSR SKTDRDDKYF SYSKLERDTR
YVSSRCRSER ERRRSRSHSR SERGPRTNLS YSRSERSHYY DSDRRYHRSS PYRERTRYSR
PYTDNRARES SDSEEEYKKT YSRRTSSHSS SYRDLRTSSY SKSDRDCKTE TSYLEMERRG
KYSSKLERES KRTSENEAVK RCCSPPNELG FRRGSSYSKH DSSASRYKST LSKPIPKSDK
FKNSFCCTEL NEEIKQSHSF SLQTPCSKGS ELRMINKNPE REKAGSPAPS NRLNDSPTLK
KLDEFPIFKS EFITHDSHDS IKELDSLSKV KNDQLRSFCP TELNINGSPG AESDLATFCT
SKTDAVLMTS DDSVTGSEVS PLVKACMLSS NGFQNISRCK GKDLDDTRML HKKSESPFRE
TEPLVSPHQD KLMSLPVMTI DYSKTVVKEP VDTRVSCCKT KDSDIYCTSN DSSNLSLCNS
EAENIEPSVI KISSNSFMNV HLESKPVICD SRNLTDHSKF ACEEYKQSIG STSSASVNHF
DDLYQPIGSS DIASSLQSLP PGIKVDSLTL LKCGENTSPV LDAVLKSRKS LEFLKHAGKE
TEVGSDLPDS GKGFASRENR RNNGLSGKCL QEAQEEGNSI LPDRRGRPEI SLHERGEGGH
VHTSDDSEVV FSSCDLNLTM EDSDGVTYTL KCDSSGHAPE IVSTVHEDYS DSSESSSDES
DSEDTDSDDS SIPRNRLQSV VVVPKNSTLP MEETSPCSSR SSQSYRHYSD HWEDERLESR
RHSYEEKFES IASKACPQTD KFFLRKGTEK NPEISFTQSS RKQIDNHLPE LSHPQSDGVD
STSHTDVKSD SLGHPNSEET VKAKISSRQQ EELPIYSSDF EDVPNKSWQQ TTFQNRPDSR
LGKTELSFSS SCEISRVDGL HSSEELRNLG WDFSQEKPST TYQQPDSSYG TCGGHKYQQN
AEQYGGTRDY WQGNGYWDPR SGRPPGTGVV YDRTQGQVPD SLTDDREEEE NWDQQDGSHF
SDQSNKYLLS IQKDKGSVQA PEISSNSIKD TLAVNEKKEF SKNLEKNDIK DRGPLKKRRQ
EIESDSESDG ELQDRKKVRV EVEQGETSVP PGSALVGPSC VMDDFRDPQR WKECAKQGKM
PCYFDLIEEN VYLTERKKNK SHRDIKRMQC ECTPLSKDER AQGEIACGED CLNRLLMIEC
SSRCPNGDYC SNRRFQRKQH ADVEVILTEK KGWGLRAAKD LPSNTFVLEY CGEVLDHKEF
KARVKEYARN KNIHYYFMAL KNDEIIDATQ KGNCSRFMNH SCEPNCETQK WTVNGQLRVG
FFTTKLVPSG SELTFDYQFQ RYGKEAQKCF CGSANCRGYL GGENRVSIRA AGGKMKKERS
RKKDSVDGEL EALMENGEGL SDKNQVLSLC RLMVRIETLE QKLTCLELIQ NTHSQSCLKS
FLERHGLSLL WIWMAELGDG RESNQKLQEE IIKTLEHLPI PTKNMLEESK VLPIIQRWSQ
TKTAVPPLSE GDGYSSENTS RAHTPLNTPD PSTKLSTDAD TDTPKKLMFR RLKIISENSM
DSAISDATSE LEGKDGKEDL DQLENVPVEE EEELQSQQLL PQQLPECKLE SETNIEASKL
PTSEPEADTE IEPKESNGTK LEEPINEETP SQDEEEGVSD VESERSQEQP DKTVDISDLA
TKLLDSWKDL KEVYRIPKKS QTEKENTTAE RGRDAVGFRD QTPAPKTPNR SRERDPDKQT
QNKEKRKRRG SLSPPPSAYE RGTKRPDDRY DTPTSKKKVR IKDRNKLSTE ERRKLFEQEV
AQREAQKQQQ QMQNLGMTSP LPYDSLGYNA PHHPFAGYPP GYPMQAYVDP SNPNAGKVLL
PTPSMDPVCS PAPYDHAQPM VGHSTEPLSA PPPVPVVPHV AAPVEVSSSQ YVTQSEGVVH
QDSSVAVLPV PAPGPVQGQN YSVWDSNQQS VSVQQQYSPA QSQATIYYQG QTCPTVYGVT
SPYSQTTPPI VQSYAQPSLQ YIQGQQIFTA HPQGVVVQPA AAVTTIVAPG QPQPLQPSEM
VVTNNLLDLP PPSPPKPKTI VLPPNWKTAR DPEGKIYYYH VITRQTQWDP PTWESPGDDA
SLEHEAEMDL GTPTYDENPM KTSKKPKTAE ADTSSELAKK SKEVFRKEMS QFIVQCLNPY
RKPDCKVGRI TTTEDFKHLA RKLTHGVMNK ELKYCKNPED LECNENVKHK TKEYIKKYMQ
KFGAVYKPKE DTELE
//
