ID A0A2K6M4K1_RHIBE Unreviewed; 702 AA.
AC A0A2K6M4K1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Centrosomal protein of 63 kDa {ECO:0000256|ARBA:ARBA00021306};
GN Name=CEP63 {ECO:0000313|Ensembl:ENSRBIP00000030691.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000030691.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000030691.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000030691.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriolar satellite
CC {ECO:0000256|ARBA:ARBA00004607}.
CC -!- SIMILARITY: Belongs to the CEP63 family.
CC {ECO:0000256|ARBA:ARBA00007181}.
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DR AlphaFoldDB; A0A2K6M4K1; -.
DR STRING; 61621.ENSRBIP00000030691; -.
DR Ensembl; ENSRBIT00000054653.1; ENSRBIP00000030691.1; ENSRBIG00000039143.1.
DR GeneTree; ENSGT00940000153190; -.
DR OMA; HYKAGLH; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0007099; P:centriole replication; IEA:Ensembl.
DR GO; GO:0045824; P:negative regulation of innate immune response; IEA:Ensembl.
DR GO; GO:1900045; P:negative regulation of protein K63-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR Gene3D; 1.20.5.340; -; 1.
DR InterPro; IPR031470; Cep63/Deup1_N.
DR PANTHER; PTHR18875:SF7; CENTROSOMAL PROTEIN OF 63 KDA; 1.
DR PANTHER; PTHR18875; SARCOMA ANTIGEN NY-SAR-24/CYTOSKELETAL PROTEIN SOJO; 1.
DR Pfam; PF17045; CEP63; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 18..279
FT /note="Centrosomal protein Cep63/Deup1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17045"
FT COILED 82..187
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 261..302
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 349..404
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 441..532
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 702 AA; 81271 MW; 14B38E88997A7919 CRC64;
MEALLERMQN RGHGGGFLTS CEAELQELMK QIDIMVAHKK SEWEGRTHAL ETCLKIREQE
LKTLRGQLDV THKEVGMLHQ QVEEHEKIKQ EMTMEYKQEL KKLHEELGIL KRSYEKLQKK
QMREFRGNTK NHREDRSEIE RLTAKIEEFR QKSLDWEKQR LIYQQQVSSL EAQRKALAEQ
SEIIQAQLAN RKQKLESVEL SSQSEIQHLS SKLERANDTI CANELEIERL TMRVNDLVGT
SMTVLQEQQT EGKLQSYLTF SQALQEEKRE LRAALQSQEN LIHEERMQKE KLQEKVKATD
TQHAVEAIRL REESLAEKKY TSQGQGDLDS VLSQLNFTHT SEELLQAEVT RLEGSLESVS
ATCKQLSQEL MEKYEELKRM EAHNNEYRAE IKKLKEQILQ GEQSYSSALE GMKMEISRLT
QELHQRDISI ASIKGSSSDM EKRLKAEMQK AEEKAVEHKE ILDQLESLKL ENRHLSEMVM
KFELGLHEAK EISLADLQEN YIEALSKLVS ENQQLQKDLM NTKSQLEIST QMCKKQNDRI
FKPTHSRTTE FKNTEFKPTH GQHRHDGIKT EHYKTGLHSP RGQASDSIDP MSRVLSPLSP
QISPCSSTRS LTSYCLCKSH SLPSALDTNE ANFSDTVSES MNDQEEFMSS CSLPVSPLGS
IATRFLEEEE LRSHHILERL DAHIEELKRE SEKTVRQFTA LK
//
