ID A0A2K6M6X8_RHIBE Unreviewed; 1468 AA.
AC A0A2K6M6X8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Adhesion G protein-coupled receptor B2 {ECO:0000313|Ensembl:ENSRBIP00000031528.1};
GN Name=ADGRB2 {ECO:0000313|Ensembl:ENSRBIP00000031528.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000031528.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000031528.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000031528.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR Ensembl; ENSRBIT00000055495.1; ENSRBIP00000031528.1; ENSRBIG00000039470.1.
DR GeneTree; ENSGT00940000160103; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR10239:SF32; ADHESION G PROTEIN-COUPLED RECEPTOR B2; 1.
DR PANTHER; PTHR10239; ISTHMIN-2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00090; TSP_1; 3.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 3.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 3.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1468
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014437447"
FT TRANSMEM 869..890
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 902..923
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 935..959
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 971..989
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1009..1032
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1053..1075
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 454..524
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 865..1106
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 217..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1258..1285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1321..1354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1398..1468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1468 AA; 159927 MW; 84378104C808505C CRC64;
MTPACPLLLS VILSLRLAAA FDPAPSACSA LASGVLYGAF SLQDLFPTIA SGCSWTLENP
DPTKYSLYLR FNRQEQVCAH FAPRLLPLDH YLVNFTCLRP SPEEAVAQAE SEVGRPEEEE
AEAAAGLELC SGSGPFTFLH FDKNFVQLCL SAEPSEAPRL LAPAALAFRF VEVLLINNNN
SSQFTCGVLC RWSEECGHAA GRACGFAQPG CSCPGEAGAG SATTTSPGPP AAHTLSNALV
PGGPAPPAEA DLHSGSSNDL FTTEMRYGEE PEEEPKVKTQ WPRSADEPGL YMAQTGDPAA
EEWSPWSVCS LTCGQGLQVR TRSCVSSPYG TLCSGPLRET RPCNNSATCP VEGQWLEWGP
WGPCSTSCAN GTQQRSRKCS VAGPAWATCT GALTDTRECS NLECPATDSK WGPWNAWSLC
SKTCDTGWQR RFRMCQATGT QGYPCEGTGE EVKPCSEKRC PAFHEMCRDE YVMLMTWKKA
AAGEIIYNKC PPNASGSASR RCLLSAQGVA YWGLPSFARC ISHEYRYLYL SLREHLAKGQ
RMLAGEGMSQ VVRSLQELLA RRTYYSGDLL FSVDILRNVT DTFKRATYVP SADDVQRFFQ
VVSFMVDAEN KEKWDDAQQV SPGSVHLLRV VEDFIHLVGD ALKAFQSSLI VTDNLVISIQ
REPVSAVSSD ITFPMRGRRG MKDWVRHSED RLFLPKEVLS LSSPGKPATS GAAGSPGRGR
GPGTVPPGPG HSHQRLLPAD PDESSYFVIG AVLYRTLGLI LPPPRPPLAV TSRVMTVTVR
PPTQPPAEPL ITVELSYIIN GTTDPHCASW DYSRADASSG DWDTENCQTL ETQAALTRCQ
CQHLSTFAVL AQPPKDLTLE LAGSPSVPLV IGCAVSCMAL LTLLAIYAAF WRFIKSERSI
ILLNFCLSIL ASNILILVGQ SRVLSKGVCT MTAAFLHFFF LSSFCWVLTE AWQSYLAVIG
RMRTRLVRKR FLCLGWGLPA LVVAVSVGFT RTKGYGTSSY CWLSLEGGLL YAFVGPAAVI
VLVNMLIGII VFNKLMARDG ISDKSKKQRA GASLWSSCVV LPLLALTWMS AVLAMTDRRS
VLFQALFAVF NSAQGFVITA VHCFLRREVQ DVVKCQMGVC RADESEDSPD SCKNGQLQIL
SDFEKDVDLA CQTVLFKEVN TCNPSTITGT LSRLSLDEDE EPKSCLVGPE GSLSFSPLPG
NILVPMAASP GLGEPPPPQE ANPVYMCGEG GLRQLDLTWL RPTEPGSEGD YMVLPRRTLS
LQPGGGGGGG EDAPRARPEG TPRRAAKTVA HTEGYPSFLS VDHSGLGLGP AYGSLQNPYG
MTFQPPPPTP SARQVPEPGE RSRTMPRTVP GSTMKMGSLE VRGCREWGVC LRLCKVMHTR
KRHSELYHEL NQKFHTFDRY RSQSTAKDKP SPGERPSLSQ HRRHQSWSTF KSMTLGSLPP
KPRERLTLHR TAAWEPTEPP DGDFQTEV
//
