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Database: UniProt
Entry: A0A2K6M8T5_RHIBE
LinkDB: A0A2K6M8T5_RHIBE
Original site: A0A2K6M8T5_RHIBE 
ID   A0A2K6M8T5_RHIBE        Unreviewed;       151 AA.
AC   A0A2K6M8T5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=Gastric inhibitory polypeptide {ECO:0000256|ARBA:ARBA00013490};
DE   AltName: Full=Glucose-dependent insulinotropic polypeptide {ECO:0000256|ARBA:ARBA00031537};
GN   Name=GIP {ECO:0000313|Ensembl:ENSRBIP00000032170.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000032170.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000032170.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000032170.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Potent stimulator of insulin secretion and relatively poor
CC       inhibitor of gastric acid secretion. {ECO:0000256|ARBA:ARBA00002766}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the glucagon family.
CC       {ECO:0000256|ARBA:ARBA00008369}.
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DR   RefSeq; XP_017709352.1; XM_017853863.1.
DR   AlphaFoldDB; A0A2K6M8T5; -.
DR   STRING; 61621.ENSRBIP00000032170; -.
DR   Ensembl; ENSRBIT00000056142.1; ENSRBIP00000032170.1; ENSRBIG00000039886.1.
DR   GeneID; 108516414; -.
DR   KEGG; rbb:108516414; -.
DR   CTD; 2695; -.
DR   GeneTree; ENSGT00390000005121; -.
DR   OMA; GHSRFHT; -.
DR   OrthoDB; 3805553at2759; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031767; F:gastric inhibitory polypeptide receptor binding; IEA:Ensembl.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR   GO; GO:0031018; P:endocrine pancreas development; IEA:Ensembl.
DR   GO; GO:0035640; P:exploration behavior; IEA:Ensembl.
DR   GO; GO:0038192; P:gastric inhibitory peptide signaling pathway; IEA:Ensembl.
DR   GO; GO:0007613; P:memory; IEA:Ensembl.
DR   GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0042304; P:regulation of fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0009749; P:response to glucose; IEA:InterPro.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
DR   Gene3D; 6.10.250.590; -; 1.
DR   InterPro; IPR039078; GIP.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR15211:SF0; GASTRIC INHIBITORY POLYPEPTIDE; 1.
DR   PANTHER; PTHR15211; GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..151
FT                   /note="Gastric inhibitory polypeptide"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014470323"
FT   DOMAIN          52..74
FT                   /note="Glucagon / GIP / secretin / VIP family"
FT                   /evidence="ECO:0000259|PROSITE:PS00260"
FT   REGION          102..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   151 AA;  16957 MW;  5685F914B749ED2F CRC64;
     MVAMKTFALL LLSLFLAVGL GEKKEGHSSL LPSLPVGSHA KVSSPQPRGP RYAEGTFISD
     YSIAMDKIHQ QDFVNWLLAQ KGKKNDWKHN ITQREARALQ LASQANRKEE EAVEPQSSPP
     KNPSDEDLLR DLLIQELLAC LVDQKNLCRR R
//
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