ID   A0A2K6M9D9_RHIBE        Unreviewed;       475 AA.
AC   A0A2K6M9D9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Ataxin-10 {ECO:0000256|ARBA:ARBA00018804};
GN   Name=ATXN10 {ECO:0000313|Ensembl:ENSRBIP00000032396.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000032396.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000032396.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000032396.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Necessary for the survival of cerebellar neurons. Induces
CC       neuritogenesis by activating the Ras-MAP kinase pathway. May play a
CC       role in the maintenance of a critical intracellular glycosylation level
CC       and homeostasis. {ECO:0000256|ARBA:ARBA00002116}.
CC   -!- SIMILARITY: Belongs to the ataxin-10 family.
CC       {ECO:0000256|ARBA:ARBA00008384}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_017706286.1; XM_017850797.1.
DR   AlphaFoldDB; A0A2K6M9D9; -.
DR   STRING; 61621.ENSRBIP00000032396; -.
DR   Ensembl; ENSRBIT00000056371.1; ENSRBIP00000032396.1; ENSRBIG00000039993.1.
DR   GeneID; 108514520; -.
DR   KEGG; rbb:108514520; -.
DR   CTD; 25814; -.
DR   GeneTree; ENSGT00390000010377; -.
DR   OMA; CAWESPP; -.
DR   OrthoDB; 5479391at2759; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR   GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019156; Ataxin-10_domain.
DR   PANTHER; PTHR13255; ATAXIN-10; 1.
DR   PANTHER; PTHR13255:SF0; ATAXIN-10; 1.
DR   Pfam; PF09759; Atx10homo_assoc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT   DOMAIN          370..460
FT                   /note="Ataxin-10"
FT                   /evidence="ECO:0000259|Pfam:PF09759"
SQ   SEQUENCE   475 AA;  53519 MW;  927CA3194E2ECBE0 CRC64;
     MAAPRPPPAR LSGIMVPAPI QDLEALRALT ALFKEQRNRE TAPRTIFQRV LDILKKSSHA
     IELACRDPSQ VENLASSLQL ITECFRCLRN ACIECSVNQN SIRNLDTIGV AVDLILLFRE
     LRVEQEALLT AFRCGLQFLG NIASRNEDSQ SIVWVHAFPE LFLSCLNHPD KKIVAYSSMI
     LFTSLNHERM KELEENLNIA IDVIDAYQKH PESEWPFLII TDLFLKSPEL VQAMFPKLNN
     QERVTLLDLM IAKITSDEPL TTDDIPVFLR HAELIASTFV DQCKTVLKLA SEEPPDDEEA
     LATIRLLDVL CEMTANTELL GYLQVFPGLL ERVIDLLRVI HVTGRETTNI FSNCGCVRAE
     GDISNVAEGF KSHLIRLIGN LCYKNKDNQD KVNELDGIPL ILDNCNISDS NPFLTQWVIY
     AIRNLTEDNS QNQDLIAKME EQGLADASLL KKVGFEVEKK GEKLILKSTR DTPKP
//