ID A0A2K6MAN6_RHIBE Unreviewed; 1843 AA.
AC A0A2K6MAN6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=SH3 and multiple ankyrin repeat domains 2 {ECO:0000313|Ensembl:ENSRBIP00000032811.1};
GN Name=SHANK2 {ECO:0000313|Ensembl:ENSRBIP00000032811.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000032811.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000032811.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000032811.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000256|ARBA:ARBA00034105}.
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DR Ensembl; ENSRBIT00000056788.1; ENSRBIP00000032811.1; ENSRBIG00000040196.1.
DR GeneTree; ENSGT00940000153561; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR CDD; cd17176; FERM_F0_SHANK2; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09506; SAM_Shank1_2_3; 1.
DR CDD; cd11983; SH3_Shank2; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032425; FERM_f0.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24135:SF17; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 2; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF16511; FERM_f0; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00248; ANK; 7.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT REPEAT 208..241
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 242..274
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 309..341
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 342..374
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 537..596
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 637..731
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1780..1843
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 961..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1080..1287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1321..1365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1432..1520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1568..1588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1629..1652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1672..1712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1750..1770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..901
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..977
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1049
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1163..1193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1266..1287
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1337
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1435..1463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1497..1520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1570..1584
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1672..1710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1754..1770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1843 AA; 200544 MW; E4CC3C94C72A397F CRC64;
MNNREFFSTQ AAMPRSPTSS EDEMAQSFSD YSVGSESDSS KEETIYDTIR ATAEKPGGAR
TEESQGNTLV IRVVIHDLQQ TKCIRFNPDA TVWVAKQRIL CTLTQSLKDV LNYGLFQPAS
NGRDGKFLDE ERLLREYPQP VGEGVPSLEF RYKKRVYKQA NLDEKQLAKL HTKTNLKKCM
DHIQHRSVEK IAKMLDRGLD PNFHDLETGE TPLTLAAQLD NSVEVIKALK NGGAHLDFRA
KDGMTALHKA ARARNQVALK TLLELGASPD YKDSYGLTPL YHTAIVGGDP YCCELLLHEH
ATVCCKDENG WHEIHQACRY GHVQHLEHLL FYGADMSAQN ASGNTALHIC ALYNQDSCAR
VLLFRGGNKE LKNYNSQTPF QVAIIAGNFE LAEYIKNHKE TDIVPFREAP AYSNRRRRPP
NTLAAPRVLL RSNSDNNLNA SAPEWAVCST ATSHRSLSPQ LLQQMPSKPE GAAKTIGSYV
PGPRSRSPSL NRLGGTGEDG KRPQPLWHVG SPFAAGAKDS LSAFEYPGPK RKLYSAVPGR
LFVAVKPYQP QVDGEIPLHR GDRVKVLSIG EGGFWEGSAR GHIGWFPAEC VEEVQCKPRD
SQAETRADRS KKLFRHYTVG SYDSFDTSSD CIIEEKTVVL QKKDNEGFGF VLRGAKADTP
IEEFTPTPAF PALQYLESVD EGGVAWQAGL RTGDFLIEVN NENVVKVGHR QVVNMIRQGG
NHLVLKVVTV TRNLDPDDTA RKKAPPPPKR APTTALTLRS KSMTSELEEL DKPEEIVPAS
KPSRAAENMA VEPRVATIKQ RPSSRCFPAG SDMNSVYERQ GIAVMTPTVP GSPKAPFLGI
PRGTMRRQKS IGITEEERQF LAPPMLKFTR SLSMPDTSED IPPPPQSVPP SPPPPSPTAY
NCPKSPTPRV YGTIKPAFNQ NSAAKVSPAT RSDTVATMMR EKGMYFRREL DRYSLDSEDL
YSRNAGPQAN FRNKRGQMPE NPYSEVGKIA SKAVYVPAKP ARRKGMLVKQ SNVEDSPEKT
CSIPIPTIIV KEPSTSSSGK SSQGSSMEID PQAPEPPCQL RADESLTVSS PFAAAIAGAV
RDREKRLEAR RNSPAFLSTD LGDEDVGLGP PAPRTRPSMF PEEGVFADED SAEQLSSPMP
GATPREPENH FVGGAEASAQ GEAGRPLNST SKAQGPESSP AVPPTSSGTA GPGNYVHPLT
GRLLDPSSPL ALALSARDRA MKESQQGPKG EAPKADLNKP LYIDTKMRPS LDAGFPTVTR
QNTRGPLRRQ ETENKYETDL GRDRKGDDKK NMLIDIMDTS QQKSAGLLMV HTVDATKLDN
ALQEEDEKAD VEMKPDSSPS EVPEGVSETE GALQISAAPE PTTVPGRTIV AVGSMEEAVI
LPFRIPPPPL ASVDLDEDFI FTEPLPPPLE FANSFDIPDD RAASVPALTD LVKQKKSDIP
QSPSLNSSQP TNSADSKKPA SLSNCLPASF LPPPESFDAV ADSGIEEVDS RSSSDHHLET
TSTISTVSSI STLSSEGGEN VDTCTVYADG QAFMVDKPPV PPKPKMKPII HKSNALYQDA
LVEEDVDSFV IPPPAPPPPP GSAQPGMAKV LQPRTSKLWG DVTEIKSPIL SGPKANVISE
LNSILQQMNR EKSAKPGEGL DSPMGAKSAS LAPRSPEIMS TISGTRSTTV TFTVRPGTSQ
PITLQSRPPD YESRTSGTRR APSPVVSPTE MNKETLPAPL SAAAASPSPT LSDVFSLPSQ
PPSGDLFGLN PAGRSRSPSP SILQQPISNK PFTTKPVHLW TKPDVADWLE SLNLGEHKEA
FMDNEIDGSH LPNLQKEDLI DLGVTRVGHR MNIERALKQL LDR
//
