ID A0A2K6MDV6_RHIBE Unreviewed; 3082 AA.
AC A0A2K6MDV6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Protein prune homolog 2 {ECO:0000256|ARBA:ARBA00039860};
DE AltName: Full=BNIP2 motif-containing molecule at the C-terminal region 1 {ECO:0000256|ARBA:ARBA00042084};
GN Name=PRUNE2 {ECO:0000313|Ensembl:ENSRBIP00000033915.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000033915.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000033915.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000033915.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PPase class C family. Prune subfamily.
CC {ECO:0000256|ARBA:ARBA00010331}.
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DR RefSeq; XP_017748200.1; XM_017892711.1.
DR STRING; 61621.ENSRBIP00000033915; -.
DR Ensembl; ENSRBIT00000057898.1; ENSRBIP00000033915.1; ENSRBIG00000040675.1.
DR GeneID; 108542636; -.
DR CTD; 158471; -.
DR GeneTree; ENSGT00940000154422; -.
DR OrthoDB; 5402707at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016462; F:pyrophosphatase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 1.
DR InterPro; IPR022181; Bcl2-/adenovirus-E1B.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR038763; DHH_sf.
DR InterPro; IPR004097; DHHA2.
DR InterPro; IPR038222; DHHA2_dom_sf.
DR PANTHER; PTHR12112; BNIP - RELATED; 1.
DR PANTHER; PTHR12112:SF11; PROTEIN PRUNE HOMOLOG 2; 1.
DR Pfam; PF12496; BNIP2; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF02833; DHHA2; 1.
DR SMART; SM01131; DHHA2; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF64182; DHH phosphoesterases; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 2889..3050
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 433..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 771..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..1080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1235..1371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1388..1451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1473..1494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1507..1591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1628..1703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1738..1768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1785..1814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1879..1903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2088..2125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2140..2221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2237..2261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2404..2423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2489..2538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2582..2631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2684..2704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2737..2758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2772..2791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2808..2827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2835..2869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..696
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..910
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..979
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..1004
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1028
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1048
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1068
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1235..1252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1330..1344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1354..1370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1410..1424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1436..1451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1629..1668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1676..1691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1746..1768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2092..2107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2108..2122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2174..2206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2237..2260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2507..2538
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2582..2599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2616..2631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2847..2861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3082 AA; 339237 MW; 0B6FCEA637A6D132 CRC64;
MEEFLQRAKS KLNRSKRLEK VHVVIGPKSC DLDSLISTFT YAYFLDKVSP PGVLCLPVLN
IPRTEFNYFT ETRFILEELN ISESFHIFRD EINLHQLNDE GKLSITLVGS NVLASEDKTL
ESAVVKVINP VEQSDANVEF RESSSSLVLK EILQEAPELI TEQLAHRLRG SILFKWMTME
SEKISEKQEE ILSVLEEKFP NLPPREDIIN VLQETQFSAQ GLSIEQTMLK DLKELSDGEI
KVAISTVSMN LENCLFHSNI TSDLKAFTDK FGFDVLILFA SYLSEEQQPR RQIAVYSENV
ELCSQICCEL EECQNPCLEL EPFDCGCDEI LVYQQEDPSV TCDQVVLIVK EVINRRCPEM
VSNSRTSSTE AVAGSAPLSQ GSSGIMELYG SDIEPQPSSV NFIENPPDLN DSNQAQVDAN
VDLVSPDSGL ATIRSSRSSK ESSVFLSDDS PVGEGTGPHH TLLPGLDSYS PIPEGAVAEE
HAWSGEHGEH FDLFNFDPAP MASGQSQQSS HSADYSPADD FFPNSDLSEG QLPAGPEGLD
GMGTNMSNYS STSLLSGAGK DSLVEYDEEF VQRQESPRDN SERNLSLTDF VGDESPSPER
LKNIGKRIPP TPMNSLVESS PSTEEPASLY TEDMTQKATD TGHMGPPQTH ARCSSWWGGL
EIDSKNIADA WSSSEQESVF QSPESWKEHK PSSIDRRASD SVFQPKSLEF TKSGPWESEF
GQPELGSSDI QDQNEESLSF QNVPMEKPPL PNASPQGTNH LIEDFASLWH SGRSPTAMPE
PWGNPTDDGE PAAAAPFPAW SAFGKEDHAE ALKNTWNLHP TSGETPSVRD PNEWAMAKGG
FVFSSSELLD NSPSEINNEA APEIWGKRNS DSRDHIFAPG NPSSDLDHTW TNSKPPKEDQ
HGLVDPKTRG KVYEKVDSWN LFEEGMKKGG SDVLAPWEDS FLSYKCSDYS ASNLGEDSVP
SPLDTNYSTS DSYTSPTCAG DEKETEHKPF AKEEGFESKD GNSTAEETDI PPQSLQQPSR
NRISSGPGNL DMWASPHTDN SSEINATHNP DENELKTEHT DGKNVSMEDD MGESSQSSYD
DPSMMQLYNE TNRQLTLLHS STNSRHTAPD SLDLWNRVIL EDTQSTATIS DMDNDLDWDD
CSGGVALPSD GQTEGYIAEG TEPETRFTVR HLEPWGLEYQ EANQVDWELP ASDEHTKDSA
PSGHHTLNEK SGQLIANSIW DSVMRDKDMS SFMLPGSSYL TDSEQSELPP EIPSHSANAK
DTHCPDAPAA SGTGESGALI SHLDNQETER ETLQSDAASL ATRLENPGHF AHPDPWKGHS
NGQSESEKEA QGATNREHLN EEEVIASGVE NASGISDKGR SDQELSSLVA SEHQEICVKS
GKISSLAVTF SPQTEEPEEV SEYEKGSYNL DSRDVQTGMS ADNLQPKDTY EKHLMSQRNS
GETTGTSDGI NFTKYVSVPE KNLEKTEECN ILEPENVGGG GPHKVPRSLD FGDAPVDSVV
HVSCTSSEIT KNLDVKGTEN SLPGASSSGN IDRDTISSEY THSSASSPEL NDSSVALSSW
GQQPSSGYQE ENQGNWSEQN HQESELITTD GQVEIVTKMK DLEKNRINEF EKSFDRKTPT
FLEIWNDSID GDSLSSLSSP ETGRYSEHSG THQESNLIAS YQEKNKHDIS ATVQPEGARA
ISTSSGSDDD SVGGEESVEE EIQVANCHVA QDESRAWESL NESNKFLVTA DPKSENIYDY
LGSSEPAENE SKSNPFCDNQ QSSPDHWNFS PLMETEIQIT AVEKEMRSSP ETGKTGDVAW
QISPKAEPKN EDNSQLEMLG FSADSTEWWN ASPQEGRLIE STFERELSDS SDVLEINSSV
YQNASPWGVP VQNDVEPVET HYTNPFSDSH QSPFLESNGK NSHEQLWNIQ PRQPDPDADK
FSQLVILDQI KEKDSRKQTF VSAAVDELTP ETPTQERCQD AMLSVCDQPD AALTHAEENG
CVTSNVSMNE GQETNQWEQE KSYLGEMTHS SIATENFPAV SSPTQLIMKP GSEWDGSAPK
EDSQGTFVPD ILHGNFQEGG ELASAAPDLW MDAKKPFSLK ADGENPDILT HCDHDSNSQA
SNSPDICHDS EAKQETEKHV GACMGPEVES SELCLTEPEM DKEPIHEPGQ ESVPSNAELD
SENAAPLPPI GNQADIKGSS QPASHKGSPE PSEINSDDNT DLQASEKGAS PDMAPILEPV
DRRIPRIENV ATSIFVTHQE PTPEGDSSWL SDSFSPESQS GARALFDGEP LLSTENPAMV
PDALLASDTC LDISEAAFDH SFSDASGLNT STGTIDDMSK LTLSEGHPET PVDGDLGKQD
ICSSEASWGD FEYDVMGQNI DEDLLREPEH FLYGGDPPLE EDSLKQSLAP YTPPFDLSYL
TEPAQSAETK EEAGSPEDES LGCRAEEIVL SALPDRRSEG NQAETKNRLP GSQLAVLHIH
EDPESIYLPV GAGANILSPS SIDWEVETDN SDLPAGGDIG PPNGDSKEIP ELEEEKVIPT
KEPEQIKSEY KEGRCTEKNE DRHALHMDYI LVNHEENLHS KPEACEERES IAELELYVGS
KETGPQGTQL ASFPDTCQPA SLNERRKGIS AEKMSSKGDA RSSFESPAQD QSWMFLGHSE
VGDPSSGPGW SGKTVEPFSE LSLGEGPQLQ ILEEMKPLES LTLEEASGPV SQLQKSKSRG
RVGPDAVTLQ AVTHDNEWEM LSPQPAQKTM IPDTEMEETE FLELETGKPR PHGLLSEDVG
MDIPFEEGVL SPSAADMRPE PPNSLDLNGT HPRRIKLTAP NINLSLDQSE GSILSDDNLD
SPDEIDINVD ELDTPDEADS FEYTGHDPTA NKDSGQESES IPEYTAEEER EDNRLWRTVV
IGEQEQRIDM KVIEPYRRVI SHGGYYGDGL NAIIVFAACF LPDSSRADYH YVMENLFLYV
ISTLELMVAE DYMIVYLNGA TPRRKMPGLG WMKKCYQMID RRLRKNLKSF IIVHPSWFIR
TILAVTRPFI SSKFSSKIKY VNSLSELSGL IPMDCIHIPE SIIKLDEELR EASEAAKTSC
LYNDPEMSSM EKDIDLKLKE KP
//
