GenomeNet

Database: UniProt
Entry: A0A2K6MIN4_RHIBE
LinkDB: A0A2K6MIN4_RHIBE
Original site: A0A2K6MIN4_RHIBE 
ID   A0A2K6MIN4_RHIBE        Unreviewed;      1705 AA.
AC   A0A2K6MIN4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=5'-3' exoribonuclease 1 {ECO:0000256|PIRNR:PIRNR006743};
DE            EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR006743};
GN   Name=XRN1 {ECO:0000313|Ensembl:ENSRBIP00000035602.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000035602.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000035602.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000035602.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR006743}.
CC   -!- SIMILARITY: Belongs to the 5'-3' exonuclease family.
CC       {ECO:0000256|ARBA:ARBA00038299, ECO:0000256|PIRNR:PIRNR006743}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   STRING; 61621.ENSRBIP00000035602; -.
DR   Ensembl; ENSRBIT00000059598.1; ENSRBIP00000035602.1; ENSRBIG00000041227.1.
DR   GeneTree; ENSGT00670000098080; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:GOC.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:Ensembl.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0071044; P:histone mRNA catabolic process; IEA:Ensembl.
DR   GO; GO:0071028; P:nuclear mRNA surveillance; IEA:Ensembl.
DR   GO; GO:0016075; P:rRNA catabolic process; IEA:Ensembl.
DR   CDD; cd18673; PIN_XRN1-2-like; 1.
DR   Gene3D; 1.25.40.1050; -; 1.
DR   Gene3D; 2.170.260.40; -; 1.
DR   Gene3D; 2.30.30.750; -; 1.
DR   Gene3D; 3.40.50.12390; -; 1.
DR   InterPro; IPR027073; 5_3_exoribonuclease.
DR   InterPro; IPR016494; 5_3_exoribonuclease_1.
DR   InterPro; IPR041385; SH3_12.
DR   InterPro; IPR040992; XRN1_D1.
DR   InterPro; IPR047007; XRN1_D1_sf.
DR   InterPro; IPR041106; XRN1_D2_D3.
DR   InterPro; IPR041412; Xrn1_helical.
DR   InterPro; IPR004859; Xrn1_N.
DR   InterPro; IPR047008; XRN1_SH3_sf.
DR   PANTHER; PTHR12341:SF7; 5'-3' EXORIBONUCLEASE 1; 1.
DR   PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR   Pfam; PF18129; SH3_12; 1.
DR   Pfam; PF18332; XRN1_D1; 1.
DR   Pfam; PF18334; XRN1_D2_D3; 1.
DR   Pfam; PF17846; XRN_M; 1.
DR   Pfam; PF03159; XRN_N; 1.
DR   PIRSF; PIRSF006743; Exonuclease_Xnr1; 2.
DR   SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR006743};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR006743};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR006743};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR006743};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   RNA-binding {ECO:0000256|PIRNR:PIRNR006743}.
FT   DOMAIN          1..227
FT                   /note="Xrn1 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03159"
FT   DOMAIN          272..597
FT                   /note="Xrn1 helical"
FT                   /evidence="ECO:0000259|Pfam:PF17846"
FT   DOMAIN          654..844
FT                   /note="5'-3' exoribonuclease 1 D1"
FT                   /evidence="ECO:0000259|Pfam:PF18332"
FT   DOMAIN          850..1075
FT                   /note="Exoribonuclease Xrn1 D2/D3"
FT                   /evidence="ECO:0000259|Pfam:PF18334"
FT   DOMAIN          1102..1171
FT                   /note="5'-3' exoribonuclease 1 SH3-like"
FT                   /evidence="ECO:0000259|Pfam:PF18129"
FT   REGION          1270..1316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1616..1705
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1281..1303
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1618..1692
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1705 AA;  193911 MW;  43E08E5B6160A4F7 CRC64;
     MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDDD VHFRISDDKI
     FTDIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKAIEKGE
     TLPTEARFDS NCITPGTEFM ARLHEHLKYF VNMKISTDKS WQGVTIYFSG HETPGEGEHK
     IMEFIRSEKA KPDHDPNTRH CLYGLDADLI MLGLTSHEAH FSLLREEVRF GGKKTQRVCA
     PEETTFHLLH LSLMREYIDY EFSVLKEKIT FKYDIERIID DWILMGFLVG NDFIPHLPHL
     HINHDALPLL YGTYITILPE LGGYINESGH LNLPRFEKYL VKLSDFDREH FSEVFVDLKW
     FESKVGNKYL NEAAGIAAEE ARNYKEKKKL KGQENSLCWA ALDKNEGEMI TSKDNLEDET
     EDDDLFETEF RQYKRTYYMT KMGVDIVSDD FLADQAACYI QAIQWILHYY YHGVQSWSWY
     YPYHYAPFLS DIRNISTLKI HFELGKPFKP FEQLLAVLPA ASKNLLPTCY QHLMTSEDSP
     IIEYYPPDFK TDLNGKQQEW EAVVLIPFID EKRLLEAMET CNHSLKKEER KRNQHSECLM
     CWYDRDTEFV YPSPWPEKFP AIERCCTRYK IISLDAWRVD INKNKITRVD QKALYFCGFP
     TLKHIKHKFF LKKSGVQVFQ QSSRGENMML EVLVDAESDE LTVENVASSV LGKSVFVNWP
     HLEEARVVAV SDGETKFYLE EPPGTQKLYS GRTAPPSKVA HLGDKEQSNW AKEVQGISEH
     YLRRKGIIIN ETSAVVYAQL LTGRKYQINQ NGEVRLEKQW SKQVVPFVYQ TIVKDIRAFD
     SRFSNIKTLD DLFPLRSMVF MLGTPYYGCT GEVQDSGDVI TEGRIRVIFS IPCEPNLDAL
     IQNQHKYSIK YNPGYVLASR LGVSGYLVSR FTGSIFIGRG SRRNPHGDHK ANVGLNLKFN
     KKNEEVPGYT KKVGSEWMYS SAAEQLLAEY LERAPELFSY IAKNSQEDVF YEDDIWPGEN
     ENGAEKVQEI ITWLKGHPVS TLSRSSCDLQ ILDAAIVEKI EEEVEKCKQR KNNKKVRVTV
     KPHLLYRPLE QQHGVIPDRD AEFCLFDRVV NVRENFSVPV GLRGTIIGIK GANREADVLF
     EVLFDEEFPG GLTIRCSPGR GYRLPTSALV NLSHGSRSET GNQKLTAIVK PQPAVHHYSS
     NSSVSCGHLG GLNHSPQSLF VPTQVSAKDD DEFCNIWQSL QGSGKMQHFQ PAVQEKGAVL
     PQEISQVNQH HKSGFNDNSV KYQQRKHDPH RKFKEEDKSP KAECWSQKMS NKQPNSGIEN
     FLASLNISKE NEVQSSHHGE PPSEEHLSPQ SFAMKGTRML KEILKIDGSN TVDHKNEMKQ
     IGNEIPVSSI RRDEYGLPSH PKQNKKLASY VNKPHSAREY HNVQSMDNVC WPAPSQIPPV
     STPVTELSRI CSLVGMPQPD FSFLRTPQTM TVCQVKLSNG LLIHGPQCHS ENEAKEKAAL
     FALQQLGSLG VNFPLPSPVF ANYPSAVPPG TIPPVFPPPT GWDHYGSNYA LGAANIMPSS
     SHLFGSMPWG PSVPVPGKPF HHTLYSGTMP MAGECQGCAQ SVYTSVTKKR VANKKNFENK
     EAQSSQATPV QTSQPDSSNI VKVSPQESSS ASLKSSQIAQ PASSFQVETA SQGRSISYHK
     STPSSSSRRK SRKLAVNFGV SKPSE
//
DBGET integrated database retrieval system