ID A0A2K6MJN7_RHIBE Unreviewed; 4478 AA.
AC A0A2K6MJN7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Dynein axonemal heavy chain 9 {ECO:0000313|Ensembl:ENSRBIP00000035990.1};
GN Name=DNAH9 {ECO:0000313|Ensembl:ENSRBIP00000035990.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000035990.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000035990.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000035990.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 61621.ENSRBIP00000035990; -.
DR Ensembl; ENSRBIT00000059992.1; ENSRBIP00000035990.1; ENSRBIG00000041572.1.
DR GeneTree; ENSGT00940000159717; -.
DR OMA; ITMDAHG; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0097729; C:9+2 motile cilium; IEA:Ensembl.
DR GO; GO:0120135; C:distal portion of axoneme; IEA:Ensembl.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0003341; P:cilium movement; IEA:Ensembl.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1865..2001
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2143..2275
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2470..2621
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2817..2920
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 790..817
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3076..3145
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3289..3337
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4478 AA; 511207 MW; E2434B782C68AB56 CRC64;
MLGAEERAAL AEENADREPG ADRRLRLLGT YVALSLRPAA GAWERCAGTA EAEQLLQAFL
DRNAAEGPRP LLVVRPGPGG LAVQPGLEVR PESGPAGAKG LFFLRTGPEP PGPNSFRGAV
VCGDLPAAPL EHLAALFSEV VLPVLANEKN RLNWPHMVCE DVRRHAHSLQ CDLSVILEQV
KGKTLLPLPA GSEKMEFVDS KSETVLDSID KSVIYAIESA VIKWSYQVQV VLKRESSQPL
LQGENPTPKV ELEFWKSRYE DLKYIYNQLR TIKVRGMAKL LDKLQSSYFP AFKAMYRDVV
AALAEAQDIH VHLIPLQHHL ETLENAEFPE VKPRLRPLLH VVCLIWATCK CYRSAGRLTV
LLQEICNLLI QQASHYLSPE DLLRSEIEES QRKLQVVSDT LSFFKQEFQD RRENLHTYFK
ENQEVKEWDF QSSLVFVQLD GFLGRLHVVE GLLKTALDFH KLGKVEFSGI RGNALSQQVQ
QMHEEFHEMY RLFSGSSSNC LYLQSMDFEN DVAEFNQKVE DLDRRLGTIF IQAFDDAPGL
EHAFKLLDIA GNLLERPLVA RDTSDKYLVL IQMFNKDLDA VRMIYSQHVQ EEAELGFSPV
HKNMPTVAGG LRWAQELRQR IQGPFSNFGR ITHPCMESAE GKRMKQKYED TLSLLEKYET
RLYEDWCRTV SEKSQYNLSQ PLLKRDPETK EITVNFNPQL LSVLKEMNYL EAREMTHIPE
TAAAIFSSRD FYRQLVANLE LMANWYNKVM KTLLEVEFPL VEEELQNIDL CLRAAEETLN
WKTEGICDYV TQITSSIHDL EQRIQKTKDN VEEIQNIMKT WVAPIFKRKD GKRESLLSLD
DQHDRMEKYY NLIKESGLKI HALVQENLGL FSADPTSNSW KTYINSIDNM LLNGFFLAIE
CSLKYLLENT ECKAGLTPIF EAQLSLAIPD LVFYPSLESG VKGGFYDIVE GLVTSIFRIS
SLVPRLSPQN GSPHYQVDLD GMPDLANMRH TLMERVQRMM GLCCGYRSTF NQYSYLYVED
QKEVLGQFLL YGHILTPEEI EDHVEDSIPE NPPLLSQFKV QIDSYETLYE EVCRLEPIKV
FDSWMKIDIR PFKASLLNII KRWSLLFKQH LVDHVTHSLA NLEAFIKNSE SGLLKKVEKG
DFQGLVEIMG HLMAVKERQS NTDEMFEPLK QTLELLKTYE QELPETVFKQ LEELPEKWNN
IKKVAITVKQ QVAPLQANEV TLLRQRCTAF DAEQQQFWER FHKEAPFRFD SIHPHQMLDA
RHIEIQQMES TMASISESAS LFEVNVPDYK QLRECRKEVC QLKELWDTIG MVTSSIHAWE
TTPWRDIKVE AMELECKQFV RHIRNLDKEV RSWDAFAGLE STVWNMLSSL RAVAELQNPA
IRERHWRQLM QATGVSFTMD QDTTLAHLLQ LQLHHYEDEV RGIVDKAAKE MGMEKTLKEL
QTTWAGMEFQ YEAHPRTSVP LLRSDEDLIE VLEDNQVQLQ NLVMSKYVAF FLEEVSGWQK
KLSTADAVIS IWFEVQRTWT HLESIFIGSE DIRAQLPQDS KRFESINIDF EELAYDGQKT
PNVVEATNKP GLYEKLEDIQ GRLCLCEKAL AEYLDTKRLA FPRFYFLSSS DLLDILSNGT
APQQVQRHLS KLFDNMAKMR FQLDASGKPT KTSLGMYSKE EEYVAFSEPC DCSGQVEIWL
NHVLSHMKAT VRHEMTEGVT AYEEKPREQW LFDYPAQVAL TCTQIWWTTE VGMAFARLEE
GYESAMKDYY KKQVAQLKTL ITMLIGQLSK GDRQKIMTIC TIDVHARDVV AKMIAQKVDN
AQAFLWLSQL RHRWDDEVQH CFANICDAQF LYSYEYLGNT PRLVITPLTD RCYITLTQSL
HLTMSGAPAG PAGTGKTETT KDLGRALGIL VYVFNCSEQM DYKSCGNIYK GLAQTGAWGC
FDEFNRISVE VLSVVAVQVK SIQDAIRDKK QWFNFLGEEI SLNPSVGIFI TMNPGYAGRT
ELPENLKALF RPCAMVVPDF ELICEIMLVA EGFIEAQSLA RKFITLYQLC KELLSKQDHY
DWGLRAIKSV LVVAGSLKRG DPDRPEDQVL MRSLRDFNIP KIVTDDMPIF MGLIGDLFPA
LDVPRRRDPN FEALVRKAIV DLKLQAEDNF VLKVVQLEEL LAVRHSVFVV GGAGTGKSQV
LRSLHKTYQI MKRRPVWTDL NPKAVTNDEL FGIINPATRE WKDGLFSSIM RELANITHDG
PKWILLDGDI DPMWIESLNT VMDDNKVLTL ASNERIPLNP TMKLLFEISH LRTATPATVS
RAGILYINPA DLGWNPPVSS WIDKREIQTE RANLTILFDK YIPTCLDTLR TRFKKIIPIP
EQSMVQMVCH LLECLLTTED IPADCPKEIY EHYFVFAAIW AFGGAMVQDQ LVDYRAEFSK
WWLTEFKTVK FPAQGTIFDY YIDPETKKFE PWSKLIPQFE FDPEMPLQAC LVHTSETIRV
CYFMERLMAR RRPVMLVGTA GTGKSVLVRA KLASLDPEAY LVKNVPFNYY TTSAMLQAVL
EKPLEKKAGR NYGPPGNKKL IYFIDDMNMP EVDAYGTVQP HTIIRQHLDY GHWYDRSKLS
LKEITNVQYV SCMNPTAGSF TINPRLQRHF SLFVLSFPGA DALSSIYSII LTQHLKLGNF
PVSLQKSIPP LINLALAFHR KVATTFLPTA IKFHYIFNLR DFANIFQGIL FSSVECVKST
RDLIRLYLHE SNRVYRDKMV EEKDFDLFDK IQREVLKKTF DDIEDPVEQT QSPNLYCHFA
NGIGEPKYMP VQSWELLTQT LVEALENHNE VNTVMDLVLF EDAMRHVCHI NRILESPRGN
ALLVGVGGSG KQSLTRLAAF ISSMDVFQIT LRKGYQIQDF KMDLASLCLK AGVKNLSTVF
LMTDAQVADE RFLVLINDLL ASGEIPDLYS DDEVENIISN VRNEVKSQGL VDNRENCWKF
FIDQVQRQLK VTLCFSPVGN KLRVRSRKFP AIVNCTAIHW FHEWPQQALE SVSLRFLQNT
EGIEPTVKQS ISKFMAFVHT SVNQTSQSYL SNEQRYNYTT PKSFLEFIRL YQSLLHRHRK
ELKCKTERLE NGLLKLHSTS AQVDDLKTKL AAQEVELKQK NEDADKLIQV VGVETDKVSR
EKAMADEEEQ KVALIMLEVK QKQKDCEEDL AKAEPALTAA QAALNTLNKT NLTELKSFGS
PPLAVSNVSS AVMVLMAPGG RVPKDRSWKA AKVTMAKVDG FLDSLINFNK ENIHENCLKA
IRPYLQDPEF NPEFVATKSY AAAGLCSWII NIVRFYEVFC DVEPKRQALS KATADLTAAQ
EKLAAIKAKI AHLNENLAKL TARFEKATAD KLKCQQEAEV TTSTISLANR LVGGLASENV
RWAEAVQNFK QQERTLCGDI LLITAFISYL GFFTKKYRQS LLDGTWRPYL SQLKTPVPVT
LTLDPLRMLM DDADVAAWQN EGLPADRMSV ENATILLNCE RWPLMVDPQL QGIKWIKNKY
GEDLQVTQIG QKGYLQIIEQ ALEAGAVVLI ENLEESIDPV LGPLLGREVI KKGRFIKIGD
KECEYNPKFR LILHTKLANP HYQPELQAQA TLINFTVTRD GLEDQLLAAV VSMERPDLEQ
LKSNLTKQQN GFKITLKTLE DSLLSRLSSA SGNFLGETAL VENLEITKQT AAEVEKKVQE
AKVTEVKINE AREHYRPAAA RASLLYFIMN DLSKIHPMYQ FSLKAFSIVF QKAVERAAPD
ESLRERVANL IDSITFSVYQ YTTRGLFECD KLTYLAQLTF QILLMNQEVN AAELDFLLRS
PVQTGTASPV EFLSHQAWGA VKVLSSMEEF CNLDRDIEGS AKSWKKFVES ECPEKEKLPQ
EWKNKTALQR LCVMRAVRPD RMTYAMRDFV EEKLGSKYVV GRALDFVTSF EESGPATPMF
FILSPGVDPL KDVESQGEKG FLLEPGLQLP RALSFLESTD LSLLDSSFKY NIHLVAKWLS
TLEKKLEEHS ENSHPEFRVF MSAEPAPSPE SHIIPQGILE NSIKITNEPP TGMHANLHKA
LDNFTQDTLE MCSRETEFKS ILFALCYFHA VVAERRKFGP QGWNRSYPFN TGDLTISVNV
LYNFLEANAK VPYDDLRYLF GEIMYGGHIT DDWDRRLCRT YLEEFIRPEM LEGELSLAPG
FPLPGNMDYN GYHQVSTSML SCPRIPYLYG LHPNAEIGFL TQTSEKLFRT VLELQPWDSQ
AGDGAGATRE EKVKALLEEI LERVTDEFNI PELMAKVEER TPYIVVAFQE CGRMNILTRE
MQRSLRELEL GLKGELTMTS HMENLQNALY CDTVPESWAR RAYPSTAGLA AWFLDLLNRI
KELEAWTGDF AMPSTVWLTG FFNPQSFLTA IMQSTARKNE WPLDQMALQC DVTKKNREEF
RSPPREGAYI HGLFMEGACW DTQAGIITEA KLKDLTPPMP VMFIKAIPAD KQDCRSVYSC
PVYKTSQRGP TYVWTFNLKT KENPSKWVLA GVALLLQI
//
