ID A0A2K6MQF7_RHIBE Unreviewed; 1605 AA.
AC A0A2K6MQF7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Latent transforming growth factor beta binding protein 4 {ECO:0000313|Ensembl:ENSRBIP00000038003.1};
GN Name=LTBP4 {ECO:0000313|Ensembl:ENSRBIP00000038003.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000038003.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000038003.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000038003.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 61621.ENSRBIP00000038003; -.
DR Ensembl; ENSRBIT00000062018.1; ENSRBIP00000038003.1; ENSRBIG00000042538.1.
DR GeneTree; ENSGT00940000158234; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:Ensembl.
DR GO; GO:0001527; C:microfibril; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0050431; F:transforming growth factor beta binding; IEA:Ensembl.
DR GO; GO:0046879; P:hormone secretion; IEA:Ensembl.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 14.
DR Gene3D; 2.10.25.10; Laminin; 20.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF198; RE68558P; 1.
DR Pfam; PF07645; EGF_CA; 17.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 3.
DR SMART; SM00181; EGF; 20.
DR SMART; SM00179; EGF_CA; 19.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 13.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 9.
DR PROSITE; PS50026; EGF_3; 13.
DR PROSITE; PS01187; EGF_CA; 8.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1605
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014427274"
FT DOMAIN 134..166
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 272..312
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 342..378
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 392..444
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 568..609
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 610..651
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 652..689
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 691..728
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 733..774
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 815..853
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 859..900
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 901..941
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1030..1071
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1162..1216
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1277..1318
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1330..1383
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1555..1599
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 459..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1110..1159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1427..1504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1130..1152
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1427..1442
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 138..148
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 156..165
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 679..688
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1605 AA; 171101 MW; 1A94993A1C591641 CRC64;
MRRPGTSGRR PLLLVLLLPL FAAAASAASP SPSLTQVVEV AGVPSRLSLA VSEASCRVRN
CQPRKCAGPQ QCLNPVPAVP SPSPSVRKRQ VSLNWQPLTL QEARALLKRR RPRGPGPGTT
EKEAPQRAPV FVLLPVLCPL ICHNGGVCVK PDRCLCPPDF AGKFCQLHSS GARPPAPAIP
GLTRSVYTMP LANHRDDEHG VASMVSVHVE HPQEASVVVH QVERVSGPWE EADAEAVARA
EAAARAEAAA PYTVLAQSAP REDGFSDASG FGYCFRELRG GECASPLPGL RTQEVCCLGA
GLAWGVHDCQ LCSERLGNSG RVGAPDGPCP TGFERVNGSC EDVDECATGG RCQHGECANT
RGGYTCVCPD GFLLDSSRSS CISQHVISEA KGPCFRVLRD GGCSLPILRN ITKQICCCSR
VGKAWGRGCQ LCPPFGSEGF REICPAGPGY HYSASDLRYN TRPLGQEPPR VSLSQPRTLP
ATSRPSAGFL PTHRPEPRPD HRPGPELPLP SIPAWIGPEI PDSGPSSGMC QRNPQVCGPG
RCISRPSGYT CACDSGFRLS PQGTRCIDVD ECRRVPPPCA PGRCENSPGS FRCVCGPGFR
AGPRAAECLD VDECHRVPPP CDLGRCENTP GSFLCVCPAG YQAAPHGASC QDVDECTQSP
GLCGRGACEN LPGSFRCVCP AGFRGSACEE DVDECAQEPP PCGPGRCDNT AGSFHCACPA
GFRSRGPGAP CQDVDECARS PPPCTYGRCE NTEGSFQCVC PTGFQPNAAG SECEDVDECE
NHLACPGQEC MNSPGSFQCR PCPPGHHLHR GRCTDVDECS SGAPPCGPHG HCTNTEGSFR
CSCAPGYRAP SGRAGPCADV NECLEGDFCF PHGECLNTDG SFACTCAPGY RPGPRGASCL
DVDECSEEDL CQSGICTNTD GSFECICPPG HRAGPDLASC LDVDECRERG PALCGSQRCE
NSPGSYRCVR DCDPGYHAGP EGTCDDVDEC QEYGPEICGA QRCENTPGSY RCTPACDPGY
QPTPGGGCQD VDECRNRSFC GAHAVCQNLP GSFQCLCDQG YEGARDGRHC VDVNECETLQ
GVCGAALCEN VEGSFLCVCP NSPEEFDPMT GRCVSPRTSA GTFPGSQPQA PASPVLPARP
PPPPPPRRPS TPRQGPVGSG RRECYFDTAA PDACDNILAR NVTWQECCCT VGEGWGSGCR
IQQCPGTETA EYQSLCPHGR GYLAPSGDPS LRRDVDECQL FRDQVCKSGV CVNTAPGYSC
YCSNGYYYHT QRLECIDNDE CADEEPACEG GRCVNTVGSY HCTCEPPLVL DGSQRRCVSN
ESQSLDDNLG VCWQEVGADL VCSHPRLDRQ ATYTECCCLY GEAWGMDCAL CPAQDSDDFE
ALCNVLRPPA YSPPRPGGFG LPYEYGPDLG PPYQGLPYGP ELYPPPALPY DPYPPPPGPF
ARREAPYGSS RFDMPDFEDD GGPYGESEAP APPGPGTRWP YRSRDTRRSF PEPEELPEGG
SYAGSLAEPY EELEAEECGI LDGCTNGRCV RVPEGFTCRC FDGYRLDMTR MACVDINECD
EAEAASPLCV NARCLNTDGS FRCICRQGFA PTHQPHHCAP ARPRA
//
