ID   A0A2K6MR42_RHIBE        Unreviewed;       411 AA.
AC   A0A2K6MR42;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=SOCS box domain-containing protein {ECO:0000259|PROSITE:PS50225};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000038226.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000038226.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000038226.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   RefSeq; XP_017743367.1; XM_017887878.1.
DR   AlphaFoldDB; A0A2K6MR42; -.
DR   STRING; 61621.ENSRBIP00000038226; -.
DR   Ensembl; ENSRBIT00000062243.1; ENSRBIP00000038226.1; ENSRBIG00000042636.1.
DR   GeneID; 108539294; -.
DR   KEGG; rbb:108539294; -.
DR   CTD; 55884; -.
DR   GeneTree; ENSGT00890000139406; -.
DR   OrthoDB; 5197664at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd03733; SOCS_WSB_SWIP; 1.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 1.10.750.20; SOCS box; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR15622:SF1; WD REPEAT AND SOCS BOX-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR15622; WD40 REPEAT PROTEIN; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50225; SOCS; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          133..155
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          156..191
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          200..241
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          242..283
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          296..330
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          375..411
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          75..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..92
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   411 AA;  46183 MW;  5CE834C2F8D1F3DE CRC64;
     MESILLSVRK QEEPLLLAEL KPGRPHQFDW KSSCETWSVA FSPDGSWFAW SQGHCIVKLI
     PWPLEEQFIP KGFEAKSRSS KNETKGRGSP KEKTLDCGQI VWGLAFSPWP SPPSRKLWAR
     HHPQVPDVSC LVLATGLNDG QIKIWEVQTG LLLLNLSGHQ DVVRDLSFTP SGSLILVSAS
     RDKTLRIWDL NKHGKQIQVL SGHLQWVYCC SISPDCSMLC SAAGEKSVFL WSMRSYTLIR
     KLEGHQSSVV SCDFSPDSAL LVTASYDTNV IMWDPYTGER LRSLHHTQVD PAMDDSDVHI
     SSLRSVCFSP EGLYLATVAD DRLLRIWALE LKTPIAFAPM TNGLCCTFFP HGGVIATGTR
     DGHVQFWTAP RVLSSLKHLC RKALRSFLTT YQVLALPIPK KMKEFLTYRT F
//