ID A0A2K6MTE2_RHIBE Unreviewed; 1791 AA.
AC A0A2K6MTE2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Pappalysin 2 {ECO:0000313|Ensembl:ENSRBIP00000039031.1};
GN Name=PAPPA2 {ECO:0000313|Ensembl:ENSRBIP00000039031.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000039031.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000039031.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000039031.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M43B family.
CC {ECO:0000256|ARBA:ARBA00008721}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR RefSeq; XP_017747185.1; XM_017891696.1.
DR STRING; 61621.ENSRBIP00000039031; -.
DR Ensembl; ENSRBIT00000063052.1; ENSRBIP00000039031.1; ENSRBIG00000042988.1.
DR GeneID; 108541924; -.
DR KEGG; rbb:108541924; -.
DR CTD; 60676; -.
DR GeneTree; ENSGT00940000158543; -.
DR OMA; TGHSRYQ; -.
DR OrthoDB; 5483399at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:Ensembl.
DR GO; GO:0060349; P:bone morphogenesis; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:Ensembl.
DR CDD; cd00033; CCP; 2.
DR CDD; cd04275; ZnMc_pappalysin_like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006558; LamG-like.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR011936; Myxo_disulph_rpt.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR043543; PAPPA/PAPPA2.
DR InterPro; IPR008754; Peptidase_M43.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR NCBIfam; TIGR02232; myxo_disulf_rpt; 1.
DR PANTHER; PTHR46130; LAMGL DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46130:SF1; PAPPALYSIN-2; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF05572; Peptidase_M43; 1.
DR Pfam; PF00084; Sushi; 2.
DR SMART; SM00032; CCP; 4.
DR SMART; SM00560; LamGL; 1.
DR SMART; SM00004; NL; 2.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 2.
DR PROSITE; PS50923; SUSHI; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1791
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014338794"
FT DOMAIN 1523..1592
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1593..1648
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 123..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1791 AA; 198914 MW; A4302F0C603596A9 CRC64;
MMCLKILRIS LAILAGWALC SANSELGWTR KKSLVEREHL NQVLLEGERC WLGAKVRRPR
ASPQHHLFGV YPSRAGNYLR PYPVEEQEIH HTGRSRPDTK GNAVNLVPRD LTENPAGLRG
AVEQPAAPWV GNSPTGQSEL LGGDDTYLGN QGSKESLGEA GTQKGSAVAA TTATTIFTTP
KEPKPETQRR GWTKSRQHRQ VWKRRAEDVW GDSDISSHFQ PWSKHSLKHR VRKSLPDKSN
QNGGEDPYRE AETFNSQVGL PILYFSGRRE RLLLRPEVLA EIPREAFTVE AWVKPEGGQN
NPAIIAGVFD NCSHTVSDKG WALGIRSGQD KGKRDARFFF SLRTDRMKKA TILISHSRYQ
PGTWTHVAAT YDGRRMALYV HGTQVASSLD QSGPLNSPFM ASCRSLLLGG DSSEDGRYFR
GHLGTLVFWS TALPQNHFQH SSQHSSGEEE ATDLVLTASF EPLNTEWVPF RDEKYPRLEV
LQGFEPEPEI LSPLRPPLCG QTVCDNVELI SRYNGYWPLR GEKVIRYQVV NICDDEGLNP
IVSEEQIRLQ HEALNEAFSR YNISWQLSVH QVHNSTLRHR VVLVNCEPSK IGNDHCDPEC
EHPLTGYDGG DCRLQGRCYS WNRRDGLCHA ECNNMLNDFD DGDCCDPQVA DVRKTCFDPD
SPKRAYMSVK ELKEALQLNS THFLNIYFAS SVREDLAGAA TWPWDKDAVT HLGGIVLSPG
YYGMPGHTDT MIHEVGHVLG LYHVFKGVSE RESCNDPCKE TVPSMETGDL CADTAPTPKS
ELCREPEAMS DTCGFTRFPG APFTNYMSYT DDNCTDNFTP NQVARMHCYL DLVYQQWTES
RKPTPIPIPP MIIGQTNKSL TIHWLPPLSG VVYDRASGSM CGACTEDGTF RQYVHTASSR
RVCDSSGYWT PEEAVGPPDV DQPCEPSLQA WSPEVHLYHM NMTVPCPTEG CSLELLFQYP
VQADTLTLWV TSFFLDSSQV LFDTEILLEN KESVHLGPLD TFCDIPLTIK LHVDGKVSGV
KVYTFDERIE IDAALLTSQP HSPLCSGCRP VRYQVLRDPP FASGLPVVVT HLHRKFTDVE
VTPGQMYRYQ VLAEAGGELG EASPPLNHIH GAPYCGDGKV SESLGEECDD GDLVSGDGCS
KACELEEGFN CVGEPSLCYM YEGDGICEPF ERKTSIVDCG IYTPKGYLDQ WATQAYSFHE
DKKKCPISLV TGEPHSLICT SYHPDLPNHR PLTGWFPCVA SANETQDDRS EQPEGSLKKE
DEVWLKVCFN RPGVARAIFI FLTTDGLVPG EHRQPTVTLY LTDVRGSNHS LGTYGLSCQH
NPLIINVTHH QNILFHHTTS VLLNFSSPRV GISAVALRTF SHIGLSAPSN CISEDEGQNH
QGQSCVHQPC GKQDSCPSLL LDHADVVNCT SIGPGLMKCA ITCQRGFALQ ASGGQYIRPM
QKEILLTCSS GHWDQNVSCL PVDCGVPNLS LVNYANFSCS EGTNFLKRCS ISCVPPAKLQ
GLSPWLTCLE DGLWSLPEVY CKLECDAPPV ILNANLLLPH CLQDNHDVGT ICKYECKPGY
YVAESADGKV RNKFLKIQCL EGGIWEQGSC IPVVCEPPPP VFEGMYECTN GFNLDSQCVL
NCNQESEKLP ILCTKEGLWT QEFKLCENLQ GECPPPPSEL NSVEYKCEQG YGIGAVCSPL
CVIPPSDPVM LPENVTADTL EHWMEPVKVQ SIVCTGRRQW HPDPILVHCI QSCEPFQADG
WCDTINNRAY CHYDGGDCCS STLSSKKVIP FAADCDLDEC TCRDPKAEEN Q
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