ID A0A2K6MUI2_RHIBE Unreviewed; 505 AA.
AC A0A2K6MUI2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Protein numb homolog {ECO:0000256|PIRNR:PIRNR017607};
GN Name=NUMB {ECO:0000313|Ensembl:ENSRBIP00000039435.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000039435.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000039435.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000039435.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in the process of neurogenesis.
CC {ECO:0000256|PIRNR:PIRNR017607}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR017607};
CC Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR017607};
CC Cytoplasmic side {ECO:0000256|PIRNR:PIRNR017607}.
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DR AlphaFoldDB; A0A2K6MUI2; -.
DR Ensembl; ENSRBIT00000063460.1; ENSRBIP00000039435.1; ENSRBIG00000043156.1.
DR GeneTree; ENSGT00940000156005; -.
DR OMA; GMSYPAP; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IEA:UniProtKB-UniRule.
DR CDD; cd01268; PTB_Numb; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016698; Numb/numb-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR47368; NUMB; 1.
DR PANTHER; PTHR47368:SF5; PROTEIN NUMB HOMOLOG; 1.
DR Pfam; PF00640; PID; 1.
DR PIRSF; PIRSF017607; Numb/numb-like; 2.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|PIRNR:PIRNR017607}; Membrane {ECO:0000256|PIRNR:PIRNR017607};
KW Neurogenesis {ECO:0000256|PIRNR:PIRNR017607};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT DOMAIN 37..173
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 267..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 505 AA; 55355 MW; 0FDF71A61D8568D4 CRC64;
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED
AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD
RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA
TFDASRTTFT REGSFRITTA TEQAEREEIM KQMQDAKKVP EVEGEAESIS SLCSQITNAF
STPEDPFSSA PMTKPVTVVA PQSPTFQGTE WGQSSGAASP GLFQAGHRRT PSEADRWLEE
VSKSVRAQQP QASAAPLQPV LQPPPPTAIS QPAPPFQGNA FLTSQPVPVG VVPALQPAFV
PAQSYPVANG MPYPAPNVPV VGITPSQMVA NVFGTAGHPQ AAHPHQSPSL VRQQTFPHYE
ASIATTSPFF KPPAQHLNGS AAFNGVDDGR LASADKHTEV PTGTCPVDPF EAQWAALENK
SKQRTNPSPT NPFTSDLQKT FEIEL
//
