ID A0A2K6MV50_RHIBE Unreviewed; 4819 AA.
AC A0A2K6MV50;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSRBIP00000039636.1};
GN Name=RYR3 {ECO:0000313|Ensembl:ENSRBIP00000039636.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000039636.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000039636.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000039636.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671,
CC ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00036634};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR Ensembl; ENSRBIT00000063663.1; ENSRBIP00000039636.1; ENSRBIG00000043251.1.
DR GeneTree; ENSGT00940000155507; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF9; RYANODINE RECEPTOR 3; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50919; MIR; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4135..4168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4362..4382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4430..4449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4561..4579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4622..4643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4702..4725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 97..152
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 159..204
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 212..266
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 272..330
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 582..793
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1239..1451
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 3867..3902
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 3295..3314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4050..4069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4819 AA; 546047 MW; A263917B3A69D50E CRC64;
MFPVLMFGSL FSRQEDEVVL QCIATIHKEQ RKLCLAAEGL GNRLCFLEPT SEAKYIPPDL
CVCNFVLEQS LSVRALQEML ANTGENGGEG AAQGGGHRTL LYGHAILLRH SFSGMYLTCL
TTSRSQTDKL AFDVGLRENA TGEACWWTIH PASKQRSEGE KVRIGDDLIL VSVSSERYLH
LSVSNGNIQV DASFMQTLWN VHPTCSGSSI EEGYLLGGHV VRLFHGHDEC LTIPSTDQND
SQHRRIFYEA GGAGTRARSL WRVEPLRISW SGSNIRWGQA FRLRHLTTGH YLALTEDQGL
ILQDRAKADT KSTAFSFRAS KELKEKLDSS HKRDIEGMGV PEIKYGDSVC FVQHTASGLW
VTYKAQDAKT SRLGPLKRKV ILHQEGHMDD GLTLQRCQRE ESQAARIIRN TTALFSQFVS
GNNRTAAPIT LPIEEVLQTL QDLIAYFQPP EEEMRHEDKQ NKLRSLKNRQ NLFKEEGMLA
LVLNCIDRLN IYNSVAHFAG IAREESGMAW KEILNLLYKL LAALIRGNRN NCAQFSNNLD
WLISKLDRLE SSSGILEVLH CILTESPEAL NLIAEGHIKS IISLLDKHGR NHKVLDILCS
LCLCNGVAVR ANQNLICDNL LPRRNLLLQT RLINDVTSIR PNIFLGVAEG SAQYKKWYFE
LIIDQVDPFL TAEPTHLRVG WASSSGYAPY PGGGEGWGGN GVGDDLYSYG FDGLHLWSGR
IPRAVASINQ HLLRSDDVVS CCLDLGVPSI SFRINGQPVQ GMFENFNTDG LFFPVMSFSA
GVKVRFLMGG RHGEFKFLPP SGYAPCYEAL LPKEKMRLEP VKEYKRDADG VRDLLGTTQF
LSQASFIPCP IDTSQVVLPP HLEKIRDRLA ENIHELWGMN KIELGWTFGK IRDDNKRQHP
CLVEFSKLPE TEKNYNLQMS TETLKTLLAL GCHIAHVNPA AEEDLKKVKL PKNYMMSNGY
KPAPLDLSDV KLLPPQEILV DKLAENAHNV WAKDRIKQGW TYGIQQDLKN KRNPRLVPYA
LLDERTKKSN RDSLREAVRT FVGYGYNIEP SDQELADSAV EKVSIDKIRF FRVERSYAVR
SGKWYFEFEV VTGGDMRVGW ARPGCRPDPL CLKAAGASVG IKEVGILGPG DVVGCMINLD
DASMIFTLNG ELLITNKGSE LAFADYEIEN GFVPICCLGL SQIGRMNLGT DASTFKFYTM
CGLQEGFEPF AVNMNRDVAV WFSKHLPTFV NVPKDHPHIE VMRIDGTMDS PPCLKVTHKT
FGTQHSNADM IYCRLSMPVE CHSSFSHSPC LDSEAFQKRK QMQEILSHTT TQCYYAVRVF
AGQDPSCVWV GWVTPDYHLY SEKFDLNKNC TVTVTLGDER GRVHESVKRS NCYMVWGGDI
VASSQRSNRS NVDLEIGCLV DLAMGMLSFS ANGKELGTCY QVEPNTKVFP AVFLQPTSTS
LFQFELGKLK NTMPLSAAIF KSEEKNPVPQ CPPRLDVQTI QPVLWSRVPN SFLKVESERV
SERHGWVVQC LEPLQMMALH IPEENRCVDI LELCEQEDLM RFHYHTLRLY SAVCALGNSR
VAYALCSHVD LSQLFYAIDN KYLPGLLRAG FYDLLISIHL ANAKERKLMM KNEYIIPITS
TTRNIRLFPD ESKRHGLPGV GLRTCLKPGF RFSTPCFVMT GEEHQKQSPE IPLESLRTKA
LSMLTEAVQC SGAHIRDPVG GSVEFQFVPV LKLIGTLLVM GVFDDDDVRQ ILLLIDPSVF
GEHSAETEEG AEKEEVTQVE EKAVEAGEKA SKEAPVKGLL QTRLPESVKL QMCELLSYLC
DCELQHRVEA IVAFGDIYVS KLQANQKFRY NELMQALNMS AALTARKTKE FRSPPQEQIN
MLLNFQLGEN CPCPEEIREE LYDFHEDLLL HCGVPLEEEE EEEEDTSWTG KLRALVYKIK
GPPKPEKEQP TEEEERCPTT LKELISQTMI CWAQEDQIQD AELVRMMFNL LRRQYDSIGE
LLQALRKTYT ISHASVSDTI NLLAALGQIR SLLSVRMGKE EELLMINGLG DIMNNKVFYQ
HPNLMRVLGM HETVMEVMVN VLSTEKSQIA FPKMVASCCR FLCYFCRISR QNQKAMFEHL
SYLLENSSVG LASPSMRGST PLDVAASSVM DNNELALGLE EPDLEKVVTY LAGCGLQSCP
MLLAKGYPDV GWNPIEGERY LSFLRFAVFV NSESVEENAS VVVKLLIRRP ECFGPALRGE
GGNGLLAAMQ GAIKISENPA LDLPSQGYKR EVTEADEEEE EIVHMGNAIM SFYSALIDLL
GRCAPEMHLI QTGKGEAIRI RSILRSLVPT EDLVGIISIP LKLPSLNKDG SVSEPDMAAN
FCPDHKAPMV LFLDRVYGIK DQTFLLHLLE VGFLPDLRAS ASLDTVSLST TEAALALNRY
ICSAVLPLLT RCAPLFAGTE HCTSLIDSTL QTIYRLSKGR SLTKAQRDTI EECLLAICNH
LRPSMLQQLL RRLVFDVPQL NEYCKMPLKL LTNHYEQCWK YYCLPSGWGS YGLAVEEELH
LTEKLFWGIF DSLSHKKYDP DLFRMALPCL SAIAGALPPD YLDTRITATL EKQISVDADG
NFDPKPINTV NFSLPEKLEY IVTKYAEHSH DKWACDKSQS GWKYGISLDE NVKTHPLIRP
FKTLTEKEKE IYRWPARESL KTMLAVGWTV ERTKEGEALV QQRENEKLRS VSQANQGNSY
SPAPLDLSNV VLSRELQGMV EVVAENYHNI WAKKKKLELE SKGGGSHPLL VPYDTLTAKE
KFKDREKAQD LFKFLQVNGV LVSRGMKDME LDASSMEKRF AYKFLKKILK YVDSAQEFIA
HLGNASSKNA TLCSLFHSVR DIGVGDTKYE SFNLCDLLNC FLFCFSLFCK LAALVRHRIS
LFGSDSTTMV SCLHILAQTL DTRTVMKSGS ELVKAGLRAF FENAAEDLEK TSENLKLGKF
THSRTQIKGV SQNINYTTVA LLPILTSIFE HVAQHQFGMD LLLGDVQISC YHILCSLYSL
GTGKNIYVER QRPALGECLA SLAAAIPVAF LEPTLNRYNP LSVFNTKTPR ERSILGMPDM
VEDMCPDIPQ LEGLMKEIND LAESGARYTE MPHVIEVILP MLCNYLSYWW ERGPENLPPS
TGQCCTKVTS EHLSLILGNI LKIINNNLGI DEASWMKRIA VYAQPIISKA RADLLRSHFI
PTLEKLKKKA VKTVQEEEQL KADGKGDTQE AELLILDEFA VLCRDLYAFY PMLIRYVDNN
RSNWLKSPDA DSDQLFRMVA EVFILWCKSH NFKREEQNFV IQNEINNLAF LTGDSKSKMS
KSGGQDQERK KTKRRGDLYS IQTSLIVAAL KKMLPIGLNM CTPGDQELIS LAKSRYGHRD
TDEEVREHLR NNLHLQEKSD DPAVKWQLNL YKDVLKSEEP FNPEKTVERV QRISAAVFHL
EQVEQPLRSK KAVWHKLLSK QRKRAVVACF RMAPLYNLPR HRSINLFLHG YQRFWIETEE
YSFEEKLVQD LAKSPKVEEE EEEETEKQPD PLHQIILYFS RNALTERSKL EDDPLYTSYS
SMMAKVHPGF LPIEKEMEKQ KTLYQQARLH ERGAAEMVLQ MISASKGEMS PMVVETLKLG
IAILNGGNAG VQQKMLDYLK EKKDAGFFQS LSGLMQSCSV LDLNAFERQN KAEGLGMVTE
EGTLIVRERG KFQFLNDEFT RDLFRFLQLL CEGHNSDFQN FLRTQMGNTT TVNVIISTVD
YLLRLQESIS DFYWYYSGKD IIDESGQHNF SKALAVTKQI FNSLTEYIQG PCIGNQQSLA
HSRLWDAVVG FLHVFANMQM KLSQDSSQIE LLKELLDLLQ DMVVMLLSLL EGNVVNGTIG
KQMVDTLVES STNVEMILKF FDMFLKLKDL TSSDTFKEYD PDGKGIISKR EFQKAMEGQK
QYTQSEIDFL LSCADADEND MFNYIDFVDR FHEPAKDIGF NVAVLLTNLS EHMPNDSRLK
CLLGPAESVL NYFEPYLGRI EIMGGAKKIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV
VNEGGEQEKM ELFVNFCEDT IFEMQLASQI SESDSADRPE EEEEDEDSSY VLEIAGEEEE
DGSFEPASAF AMACASVKRN VADFLKRATL KNLRKQYRNV KKMTAKELVK VLCSFFWMLF
LGLFQMLFTI LGGIFQVLWS TVFGGGLVEG AKNIRVTKIL GDMPDPTQFG IHDDTMEAER
AEVMEPGITT ELVHFIKGEK GDTDIMSDLF GLHPKKEGSL KHGPEVGLGD LSEIIGKDEP
PTLESTVQKK RKAQAAEMKA ANEAEGKVES EKADINYSNC YEKEDKDKEE EQAEYLWTEV
TKKKKRRCGQ KVEKPEAFTA NFFKGLDIYQ TKLLHYLARN FYNLRFLALF VAFAINFILL
FYKVTEEPLE EETEDVANLW NSFNDEEEEE AMVFFVLQES TGYMAPTLRA LAVIHTIISL
VCVVGYYCLK VPLVVFKREK EIARKLEFDG LYITEQPSED DIKGQWDRLV INTPSFPNNY
WDKFVKRKVI NKYGDLYGAE RIAELLGLDK NALDFSPVEE TKAEAASLVS WLSSIDMKYH
IWKLGVVFTD NSFLYLAWYT TMSVLGHYNN FFFAAHLLDI AMGFKTLRTI LSSVTHNGKQ
LVLTVGLLAV VVYLYTVVAF NFFRKFYNKS EDDDEPDMKC DDMMTCYLFH MYVGVRAGGG
IGDEIEDPAG DPYEMYRIVF DITFFFFVIV ILLAIIQGLI IDAFGELRDQ QEQVREDMET
KCFICGIGND YFDTTPHGFE THTLQEHNLA NYFLLWFRNK HPLFTLFQES YVWKMYQERC
WDFFPAGDCF RKQYEDQLG
//
