ID A0A2K6MVG8_RHIBE Unreviewed; 1376 AA.
AC A0A2K6MVG8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Pro-interleukin-16 {ECO:0000256|RuleBase:RU363135};
DE Contains:
DE RecName: Full=Interleukin-16 {ECO:0000256|RuleBase:RU363135};
DE Short=IL-16 {ECO:0000256|RuleBase:RU363135};
DE AltName: Full=Lymphocyte chemoattractant factor {ECO:0000256|RuleBase:RU363135};
DE Short=LCF {ECO:0000256|RuleBase:RU363135};
GN Name=IL16 {ECO:0000256|RuleBase:RU363135,
GN ECO:0000313|Ensembl:ENSRBIP00000039753.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000039753.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000039753.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000039753.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Interleukin-16 stimulates a migratory response in CD4+
CC lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2
CC and IL-15 responsiveness. Also induces T-lymphocyte expression of
CC interleukin 2 receptor. Ligand for CD4. {ECO:0000256|ARBA:ARBA00024706,
CC ECO:0000256|RuleBase:RU363135}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU363135}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU363135}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU363135}.
CC Secreted {ECO:0000256|RuleBase:RU363135}.
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DR RefSeq; XP_017742325.1; XM_017886836.1.
DR STRING; 61621.ENSRBIP00000039753; -.
DR Ensembl; ENSRBIT00000063781.1; ENSRBIP00000039753.1; ENSRBIG00000043336.1.
DR GeneID; 108538645; -.
DR KEGG; rbb:108538645; -.
DR CTD; 3603; -.
DR GeneTree; ENSGT00940000156178; -.
DR OMA; FFTKEAS; -.
DR OrthoDB; 3848080at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0090543; C:Flemming body; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0042609; F:CD4 receptor binding; IEA:Ensembl.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0050930; P:induction of positive chemotaxis; IEA:Ensembl.
DR GO; GO:0030595; P:leukocyte chemotaxis; IEA:Ensembl.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032730; P:positive regulation of interleukin-1 alpha production; IEA:Ensembl.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl.
DR CDD; cd00992; PDZ_signaling; 4.
DR Gene3D; 2.30.42.10; -; 4.
DR InterPro; IPR020450; IL-16.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR48396; PRO-INTERLEUKIN-16; 1.
DR PANTHER; PTHR48396:SF2; PRO-INTERLEUKIN-16; 1.
DR Pfam; PF00595; PDZ; 3.
DR PRINTS; PR01931; INTRLEUKIN16.
DR SMART; SM00228; PDZ; 4.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR PROSITE; PS50106; PDZ; 4.
PE 4: Predicted;
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500, ECO:0000256|RuleBase:RU363135};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU363135};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU363135};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU363135};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU363135};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 263..349
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 402..472
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1156..1241
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1278..1363
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1062..1089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..670
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..915
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..1000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1376 AA; 146858 MW; D959E142212FF3EB CRC64;
MSLQKRVFPR RQNGTHEVAA KPCPVATRQP RARDQERKKG SFTSSLRMES HSRTGKNRKS
AKFRSISRSL MLCNAKTSDD GSSPDEKYPD PSEISLAQGK EGIFHSSVQL ADTSEAGPSS
IPDLALASEA AQLQVAGNDR GKTCRRIFFM KESSTASSRE KPGKPEAQSS NFLFPKACHQ
RARSNSTSVN PYCTREIDFP MTKKSAASTD RQPYSLCSNR KSLSQQLDCP AGKAAGTSRP
TRSLSTAQLV QPSGGLQASV ISNIVLMKGQ AKGLGFSIVG GKDSIYGPIG IYVKTIFAGG
AAAADGRLQE GDEILELNGE SMAGLTHQDA LQKFKQAKKG LLTLTVRTRL MAPPSLCSHL
SPPLCRSLSS STCITKDSSS FSLESPSAPI STAKPNYRIM VEVSLQKEAG VGLGIGLCSV
PYFQCISGIF VHTLSPGSVA HLDGRLRCGD EIVEISDSPV HCLTLNEVYT ILSHCDPGPV
PIIVSRHPDP QVSEQQLKEA VAQAVENTKF GKERHQWSLE GVKRLESSWH GRPTLEKERE
KNSAPPHRRA QKIMIRSSSD SSYMSGSPGG SPGSGSAGKP SSDVDISTHS PSLPLAREPV
VLSIASSRLP QESPPVPESQ DSHPPLRLKK PFEILVRKPT SSKPKPPPRK YFKSDSDPQK
SLEEREKSSC SSGHTPPTCG QEARELLPLL LPQEDTAGRS PSASASCPGP GICPQTKSST
EGEPGWRRAS PVTQTSPIKH PLLKRQARMD YSFDTTAEDP WVRISDCIKN LFSPIMSENP
GHMPLQPNAS LSEEDGTQGH PDGTPPKLDT ANGTPKVYKS ADRSTVKKGP PVAPKPAWFR
QSLKGLRNRA SDPRGLPDPA LSTQPAPASR EHLGPHIRAS SSSSSSIKQR ISSFETFGSS
QLPDKGAQRL SLQPSSGEAA KPLGKHEGGL LGRGAAPTLV PQQPEQVLPS GSPAAMEARD
PGVSESPPPG LQPNQKTLPT GSDPLLRLLS TQTEKSQGPV LKMPSQRARS FPLTRSQSCE
TKLLDEKTSK LYSISSQVSS AVMKSLLCLP SSLSCAQTPC IPKEGASPTS SSNEDSAANG
SAETSASDTG FSLNLSELRE YTEGLTEAKE DDDGDHSSHQ SGQSVISLLS SEELKQLIEE
VKVLDEATLK QLDSIHVTIL HKEEGAGLGF SLAGGADLEN KVITVHRVFP NGLASQEGTI
QKGNEVLSIN GKSLKGTTHN DALAILRQAR EPRQAVIVTR KLTAESMPDL NSTTDSAASA
SAASDVSVES SAEATVYTVT LEKISAGLGF SLEGGKGSLH GDKPLTINRI FKGAASEQSE
TIQPGDEILQ LAGTAMQGLT RFEAWNIIKA LPDGPVTIVI RRKSLQPKET IAAAES
//
