ID   A0A2K6MVQ6_RHIBE        Unreviewed;       367 AA.
AC   A0A2K6MVQ6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=L-lactate dehydrogenase {ECO:0008006|Google:ProtNLM};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000039851.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000039851.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000039851.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily.
CC       {ECO:0000256|RuleBase:RU003369}.
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DR   AlphaFoldDB; A0A2K6MVQ6; -.
DR   STRING; 61621.ENSRBIP00000039851; -.
DR   Ensembl; ENSRBIT00000063880.1; ENSRBIP00000039851.1; ENSRBIG00000043377.1.
DR   GeneTree; ENSGT00940000163242; -.
DR   OMA; FLNIPCV; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   CDD; cd05293; LDH_1; 1.
DR   Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR   PANTHER; PTHR43128:SF8; L-LACTATE DEHYDROGENASE A-LIKE 6B; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   PRINTS; PR00086; LLDHDRGNASE.
DR   SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003369};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180}.
FT   DOMAIN          58..183
FT                   /note="Lactate/malate dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00056"
FT   DOMAIN          187..346
FT                   /note="Lactate/malate dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02866"
SQ   SEQUENCE   367 AA;  39758 MW;  D4E2732B44535A60 CRC64;
     MSGTVPVVSA GANFLCLGMA PCVPLKGAWL FTPLSNMATV KSELTEHFTS KERVHRSKVS
     IVGTGSVGMA CPISILLKGL SDELAIVDPD EGKLKGETVD LQNGSPFMKM PSTVCSKDYL
     VTANSSLVIV TAGAHQEKGE TRLNLLMISG IVQYSPLYKL IIVYNPLDVL TYLSAFPKNR
     VIGSGCNLGT ARFHFLIGQK LGIHSESCRG WILREHGDSS VPVWSGVNIA GVPLKDLDSD
     IGTDKDPEQW KNVHKEVIAS AYEIIKMNTS CTIGLSVADL TESILKNLRR THPVSTIIKG
     LYEIDEEVFL SIPCILGENG ITNLIKIKLT PEEEAHLKEC KNTLGNSEGA EALKLSKTTI
     LKLLKRS
//