ID A0A2K6MVS3_RHIBE Unreviewed; 1083 AA.
AC A0A2K6MVS3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LATS2 {ECO:0000313|Ensembl:ENSRBIP00000039871.1};
OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Rhinopithecus.
OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000039871.1, ECO:0000313|Proteomes:UP000233180};
RN [1] {ECO:0000313|Ensembl:ENSRBIP00000039871.1, ECO:0000313|Proteomes:UP000233180}
RP NUCLEOTIDE SEQUENCE.
RA Wu, C.-I. and Zhang, Y.;
RT "Genome of Rhinopithecus bieti.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRBIP00000039871.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_017714624.1; XM_017859135.1.
DR RefSeq; XP_017714632.1; XM_017859143.1.
DR AlphaFoldDB; A0A2K6MVS3; -.
DR STRING; 61621.ENSRBIP00000039871; -.
DR Ensembl; ENSRBIT00000063900.1; ENSRBIP00000039871.1; ENSRBIG00000043386.1.
DR GeneID; 108519857; -.
DR KEGG; rbb:108519857; -.
DR CTD; 26524; -.
DR GeneTree; ENSGT00940000159161; -.
DR OMA; FNNHQQP; -.
DR OrthoDB; 5348633at2759; -.
DR Proteomes; UP000233180; Unplaced.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0035329; P:hippo signaling; IEA:Ensembl.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0001827; P:inner cell mass cell fate commitment; IEA:Ensembl.
DR GO; GO:0001828; P:inner cell mass cellular morphogenesis; IEA:Ensembl.
DR GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:1900181; P:negative regulation of protein localization to nucleus; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR GO; GO:0046620; P:regulation of organ growth; IEA:Ensembl.
DR GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR CDD; cd21777; MobB_LATS2; 1.
DR CDD; cd05626; STKc_LATS2; 1.
DR CDD; cd14398; UBA_LATS2; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR017892; Pkinase_C.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR24356; SERINE/THREONINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR24356:SF149; SERINE_THREONINE-PROTEIN KINASE LATS2; 1.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF00433; Pkinase_C; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 98..139
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 663..968
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 969..1047
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT REGION 23..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1051..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 692
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1083 AA; 119808 MW; D32E927406101058 CRC64;
MRPKTFPATT YSGNSRQRLQ EIREGLKQPS KSSAQGLPVG PNSDTSLDAK VLGSKDAARQ
QQQMRATPKF GPYQKALREI RYSLLPFANE SGTSAAAEVN RQMLQELVNA GCDQEMAGRA
LKQTGSRSIE AALEYISKMG YLDPRNEQIV RVIKQTSPGR GLMPAPVTRR PSFEGTSDSF
ASYHQLSGAP YEGPSFGADG PTALEEVPRP YVDYLFPGVG PHGPSHQHQH QHPPKGYGAS
VEAAGAHFPL QGAHYGRPHL LVHGEPLGYG VQRSPSFQSK TPPETGGYAT KGQGGPPGAG
LAFPPPTAGL YVPHPHHKQA GPTAHQLHVL GSRSQVFASD SPPQSLLTPS RNSLNVDLYD
LGSTSVQQWP AATLARRDSL QKPGLEAPPR AHVAFRPDCP VPSRTNSFNS HQPRPGAPGK
AEPSLPAPNT VTAVTAAHIL HPVKSVRVLR PEPQTAVGPS HPAWVPAPAP APAPATEGLD
AKEEHALALG GAGAYPLDVE YGGPDRRCPP PPYPRHLLLR SKSEQYDLDS LCAGVEQSLR
AGPSEPEGGE KSRKSAKGDK GGKDKKQIQT SPVPVRKNSR DEEKRESRIK SYSPYAFKFF
MEQHVENVIK TYQQKVNRRL QLEQEMAKAG LCEAEQEQMR KILYQKESNY NRLKRAKMDK
SMFVKIKTLG IGAFGEVCLA CKVDTHALYA MKTLRKKDVL NRNQVAHVKA ERDILAEADN
EWVVKLYYSF QDKDSLYFVM DYIPGGDMMS LLIRMEVFPE HLARFYIAEL TLAIESVHKM
GFIHRDIKPD NILIDLDGHI KLTDFGLCTG FRWTHNSKYY QKGSHVRQDS MEPSDLWDDV
SNCRCGDRLK TLEQRARKQH QRCLAHSLVG TPNYIAPEVL LRKGYTQLCD WWSVGVILFE
MLVGQPPFLA PTPTETQLKV INWENTLHIP AQVKLSPEAR DLITKLCCSA DHRLGRNGAE
DLKAHPFFSA MDFSSDIRKQ PAPYVPTISH PMDTSNFDPV DEESPWNDAS EGSAKAWDTL
TSPSNKHPEH AFYEFTFRRF FDDNGYPFRC PKPSGAEASQ SENADLEASD LVDQTEGCQP
VYV
//